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PubMed1959

Third International Reference Preparation of cardiolipin with special reference to its use in improved serological tests for treponematoses.

The Third International Reference Preparation of Cardiolipin was produced (in a quantity of 2400 ml) at the WHO Serological Reference Centre, Copenhagen, and assayed in 1957 against the Second International Reference Preparation by four laboratories in three countries. Complement-fixation and slide flocculation tests were used. The new preparation was found acceptable, and its establishment was authorized by the WHO Expert Committee on Biological Standardization.The average log(10) titres and results of analyses of variances are shown. The variances were of the usual order of magnitude, and the differences in titre between antigens containing the Second and the Third International Reference Preparations varied from -0.004 to 0.059; only two of the differences exceeded the 5% limit of significance.The use of the Third International Reference Preparation in tests for the acceptability of any new cardiolipin preparation is described.

Biological Assay↗
PubMed1956

Serology of treponematoses; recent developments.

In this general review of the serology of the treponematoses and of syphilis in particular, the authors first consider recent technical improvements in the materials used by serological laboratories and in the tests they perform. Special stress is laid on the new tests using treponemal antigens; but it is pointed out that the more commonly used tests should not be discarded in routine testing, the particular value of the newer tests residing in their use on doubtful sera.Mass blood testing-whether as a result of legal requirement and regulation or in the routine testing of patients and industrial workers-is extremely valuable where there is much syphilis among the population tested but becomes very costly when the number of positive reactors found is small.In a section on the clinical implications of serological findings, the authors deal with the problems presented by seropositive pregnant women and newborn children, with quantitative serological tests for syphilis, with the serological response in penicillin-treated syphilis, and with the serology of asymptomatic reinfection and serorelapse.

Child↗