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PubMed1952

TEM.

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Neoplasms↗
PubMed1957

The action of triethylenemelamine on the fertility of male rats.

Small doses of triethylenemelamine (TEM) had a selective action on the fertility of male rats. One dose (0.2 mg./kg., i.p.) produced effects ranging from subfertility to sterility during the next 3 weeks. In the fourth week sterility was the rule, but normal fertility was restored in the fifth week. A short course of the drug (5 daily doses, 0.2 mg./kg., i.p.) resulted in sterility lasting about 5 weeks, after which fertility was rapidly regained. Daily doses (0.05 mg./kg., i.p.) caused infertility in about a week which was maintained throughout treatment (7 weeks), and persisted for several weeks after the drug was discontinued. Sexual activity of infertile animals seemed normal and sperm production appeared to continue. Spermatozoa from infertile animals were able to reach and penetrate ova. The results suggest that TEM acts directly on the germinal epithelium. An attempt has been made to provide some explanation for these results and correlate them with the time required for spermatogenesis.

Animals↗
PubMed1959

The effect of alkylating agents on male rat fertility.

The effects of tumour inhibitory doses of tretamine (triethylenemelamine), busulphan, and melphalan on the fertility of male rats have been examined. The aromatic nitrogen mustard, melphalan, was inactive, but busulphan has a highly selective action on spermatogenesis which contrasts strikingly with that of tretamine. The main action of tretamine was exerted upon spermatocytes or spermatids, but, with increasing dose, the effects spread to involve a wide range of spermatogenic cells including mature sperm, so that infertility could be induced very rapidly. Busulphan, however, interfered with the development of spermatogonia for several weeks, although other germinal cells were unaffected and continued to develop into mature spermatozoa. This accounted for the continuation of normal fertility for 7 weeks after a dose, before sterility suddenly developed. The antifertility activity of tretamine could be simulated by a variety of other ethyleneimino compounds, potency being greatest in trifunctional and least in monofunctional compounds. The latter were, however, very destructive to the seminiferous epithelium with increasing dose. In the rat, there appeared to be no definite relationship between the ability of alkylating substances to interfere with the activity of normal and pathological proliferating tissues, as represented by the germinal epithelium, haematopoietic, and tumour tissue. Although carcinogenicity was a biological property of alkylating agents, other chemical types of carcinogen did not interfere with fertility.

Alkylating Agents↗