[Pulmonary tuberculosis & urogenital tuberculosis, diagnostic aspects].
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Urogenital tuberculosis has not decreased in incidence like other forms of tuberculosis and this is not to be expected in the coming years. Following combined modern chemotherapy the chances of conversion and also clinical cure are increased. The patient's cooperation during a systematic triple drug therapy in adequate dosage is important. The possibility of ambulatory treatment will depend on the clinical findings and the patient's social situation. Physical and occupational therapy and early resocialization of the patient are important. Prolonged unemployment should be avoided. Urological care of the patient is particularly important in the early phases of the treatment.
Urogenital tuberculosis has unspecific clinical symptomatology. This is often a result of the complications of the disease. Clinical symptoms, X-ray examinations, urinary microscopy, cultures and cytological and histological examinations may reveal the diagnosis. Initial treatment is medical therapy, but surgery will often be a necessary supplement. Follow-up during the treatment period is important to avoid unnecessary complications. With appropriate treatment and follow-up, the prognosis will be good.
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The urogenital tuberculosis has undergone a change in form and clinical assessment. The absolute proportion of urogenital tuberculosis cases has fallen off sharply since 1967. The nmber of surgical interventions is also remarkably reduced. The cases exhibiting a milder stage have significantly increased, while the severe cases have decreased. This change of tuberculosis has made a conservative therapy favorable; therefore the current operative indication is somewhat different than 15 years ago. The time of release from the stationary treatment depends first on the animal experiment and bacterial findings; furthermore, tests are necessary to determine the status of immunity. It was revealed with urogenital tuberculosis, through regular examination of the menstrual blood of women, that the number of positive cases among women was considerably higher, than among men. In contracted bladder a surgical intervention is often necessary due to intense pain and incontinence. We prefer the rectal bladder with sigmoid pull-through inside the sphincter ani, whereby excellent success can be achieved. The study shows that the clinical assessment of tuberculosis is somewhat different today than is was earlier. Tuberculosis underwent a change in form that must be taken into consideration with respect to operative indication.
Urogenital tuberculosis raises major diagnostic problems due to the frequently atypical and misleading clinical features. It is a serious disease as the lesions are often multifocal and extensive, requiring major surgical resection and urinary tract reconstruction. Prevention of this disease is based on generalization of BCG immunization and adequate treatment of pulmonary tuberculosis. Between 1985 and 1995, 80 patients with urogenital tuberculosis were treated in our department. These patients consisted of 50 males (62.5%) and 30 females (37.5%) with a mean age of 38 years (range: 20 to 50 years). IVU revealed silent kidney in 26% of cases, ureterohydronephrosis in 36% of cases, small bladder in 17% of cases, and was normal in only 5% of cases. Renal function was impaired in 32% of patients. The diagnosis was confirmed by a positive test for AFB in the urine in 64% of cases, bladder biopsy in 20% of cases and pathological examination of the operative specimen in 20% of cases. Treatment consisted of temporary urinary diversion (32%), antituberculous chemotherapy in all patients, and corticosteroid therapy in 8.7% of patients. Surgical treatment was required in 95% of patients: partial nephrectomy (2.5%), nephrectomy (50%), enterocystoplasty (18%), ileoureteroplasty (5%), ureteric reimplantation (12.5%), ureterocaliceal anastomosis (1.2%).
Urogenital tuberculosis, although often forgotten, remains a common and serious disease. Over a period of 10 years (1963 to 1973) 52 patients were seen and treated on our unit. There were 4 deaths all due to intercurrent disease, and 24 patients, i.e. half the survivors list one kidney owing to the tuberculosis. These crude figures, when one considers that they were mostly middle-aged adults, give an idea of the serious nature of urogenital tuberculosis in 1974.
Urogenital tuberculosis still represents a major urologic problem in the northern part of Africa, and it is a serious disease because its diagnosis is usually late. Furthermore, the affection is frequently bilateral, which may cause the renal failure. 86 cases of urogenital tuberculosis have been reviewed. Our patients were young adults (average age: 34 year old). Cystitis is the most frequent sign (74%), hematuria, lumbar pain, genital signs and nephrologic signs are not rare. Urine was negative in 46 patients, and amicrobial leucocyturia was present in 24 cases. Diagnosis relies on a range of signs, especially intravenous pyelography that has an important place. Endoscopic biopsy did confirm the diagnosis of tuberculosis in 12 patients. Generally, definitive diagnosis was based on the histologic study of the operative specimen.
The study was carried out in hospital patients as well as in outpatients at the National Centre of Tuberculosis and Lung Diseases of Georgia (2002-2004). The group consisting of 32 patients with tuberculosis of urogenital system has been studied (newly detected forms). Except clinical laboratory, culture and X-ray contrast methods, two additional methods were used in testing of this group of patients. The examination of their urine, at the same time, was carried out by the Polymerase Chain Reaction method in order to detect Kochi bacillus and by three-time bacterioscopy of urine for acid resistant bacteria. Mycobacterium tuberculosis in urine has been detected in 26 (81,25%) patients by PCR method, and by urine bacterioscopy--acid fast bacilli (AFB+) in 18 (56,25%) patients. The histo-morphological investigation of specimens obtained by surgery confirmed the TB diagnosis in all patients. This study on patients suspected of Tuberculosis of genital-urinary system gives us an opportunity to update the diagnostic algorithm by including the modern molecular methods. This algorithm will help in timely detection of Tuberculosis, in selection of adequate therapy and in prevention of the further progression of the disease.
The timely diagnosis of urogenital tuberculosis and the early initiation of specific therapy are an essential prerequisite to the maximum maintenance of function of an affected organ and to a good prognosis of the disease. Analysis of 205 history cases in patients with new-onset urogenital tuberculosis who were examined and treated at our hospital in 1999-2003 has revealed advanced destructive urogenital tuberculosis in 56.1% of cases. The able-bodied patients were 58.05%. Medical examination determined disability group II in 27.8%. The able-bodied patients who were recognized to be disabled were 57.89%. Since the highest disability rates (34.15%) among the patients with new-onset urogenital tuberculosis were observed in the group of the most able-bodied age (41-50 years), this condition inflicts a great economic loss. The true disability rates are higher than those observed by us since some patients undergo medical examination in their local tuberculosis dispensaries and fail to be statistically registered at our hospital.
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