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At least 19 recordsLinked to original sources
PubMedDate not supplied

Congenital spinal lipomas--tumor versus hamartoma.

Congenital spinal lipomas as a form of dysraphism are frequently reported in literature. A few studies have highlighted their histologic features and found them different from lipomas in other parts of the body. In a review of eight cases of spinal lipomas, we found heterotopic tissue in seven. Neural tissue, muscle, bone and cartilage were frequently encountered. The presence of meningothelial cells in one case was an unusual finding. These findings support the concept of their hamartomatous origin. Malignancy, occurring later in life in one of the heterotopic elements is known, though uncommon, and is one of the reasons, besides neurologic deficit, for long term follow-up.

Child, Preschool↗
PubMed1977

Non-epithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx: a clinicopathologyic study. VIII. Adipose tissue tumors (lipoma and liposarcoma).

In a study of 256 non-epithelial neoplasms involving the nasal cavity, paranasal sinuses and nasopharynx, only two lesions were classified as adipose tissue tumors (one lipoma and one liposarcoma). The lipoma was found incidentally when tissue removed from the maxillary sinus was studied histologically, the patient having been treated with a Caldwell-Luc procedure for maxillary sinusitis. The liposarcoma produced a large mass involving the nasal cavity, maxillary sinus, ethmoid area, hard palate and maxillary, temporal and sphenoid bones. The tumor extended into the cranial cavity and eventually led to the patient's death. The problems involved in histologically differentiating liposarcomas from other lesions are discussed. Even though adipose tissue tumors are among the most common soft tissue neoplasms, these lesions rarely occur in the nasal cavity, paranasal sinuses and nasopharynx.

Adult↗
PubMed1982

[Two further cases of rare laryngeal tumors. Lipoma and chemodectoma (author's transl)].

The cases of laryngeal tumors requiring surgical excision are presented. The first case was that of patient with a laryngeal lipoma of atypical appearance, histological findings suggesting a hamartoma. The second patient had a chemodectoma, diagnosis being difficult but facilitated by super-selective arteriography, requiring delicate excision which was almost bloodless as a result of previous embolization. Clinical and pathological features of these tumors reviewed, and problems related to their treatment discussed. The authors have previously reported 4 other rare types of laryngeal tumor.

Female↗
PubMed2005

Video-assisted thoracoscopic resection of a giant anterior mediastinal tumor (lipoma) using an original sternum-lifting technique.

We report here the complete thoracoscopic resection of a giant lipoma (18x15x5 cm, 560 g) in a 33-year-old man using an original sternum-lifting technique. The patient had an uncomplicated postoperative course and was discharged on the seventh postoperative day. This is the largest reported anterior mediastinal tumor that was completely resected by video-assisted thoracic surgery without median sternotomy or thoracotomy. This original method may be useful from the standpoint of minimal access, rapid recovery, less pain, and good cosmetic results for an anterior mediastinal giant tumor.

Adult↗
PubMed1995

Bilateral peripelvic fat simulating renal pelvic tumor.

Lipomas are benign tumors which may simulate peripelvic masses and usually originate in the renal cortex or the perirenal adipose tissue. Excessive proliferation of the peripelvic fat of the kidney simulating a renal pelvic tumor was detected in our case, illustrating a rare instance in which the kidney was salvaged.

Adipose Tissue↗
PubMed1997

Loss of heterozygosity at 11q13: analysis of pituitary tumors, lung carcinoids, lipomas, and other uncommon tumors in subjects with familial multiple endocrine neoplasia type 1.

Loss of heterozygosity (LOH) for polymorphic markers flanking the multiple endocrine neoplasia type 1 (MEN-1) gene in parathyroid and pancreatic islet tumors from subjects with familial MEN-1 (FMEN-1) has been well documented and has led to the hypothesis that the MEN-1 gene functions as a tumor suppressor. To assess the role of the MEN-1 gene in the pathogenesis of tumors less commonly associated with MEN-1, we employed a large number of highly informative polymorphic markers closely linked to the MEN-1 gene to study a series of 13 such tumors from subjects with FMEN-1 for LOH at 11q13. We were able to identify LOH for 1 or more 11q13 markers in 2 of 3 pituitary tumors, 3 lung carcinoids, and 1 of 2 lipomas. In every case studied, the allele lost represented the normal allele inherited from the unaffected parent. No LOH was detected in 3 skin angiofibromas, an esophageal leiomyoma, or a renal angiomyolipoma despite the presence of at least 2 informative markers for each tumor. Our results suggest that, like that for parathyroid and pancreatic islet tumors, the pathogenesis of pituitary tumors, lung carcinoids, and lipomas occurring in subjects with FMEN-1 probably involves loss of the normal tumor suppressor function of the MEN-1 gene. Our inability to detect 11q13 LOH in skin angiofibromas, leiomyoma, and angiomyolipoma from subjects with FMEN-1 is consistent with the possibility that these neoplasms arose independently by a mechanism unrelated to the MEN-1 gene, but a role for the MEN-1 gene in the pathogenesis of these tumors cannot be definitively excluded until the gene itself is identified and evaluated for small intragenic deletions or point mutations in such tumors.

Adult↗
PubMed1990

[Perineal tumors in male patients].

Perineal tumors are rare and are malignant primaries in 66% of cases. We treated three patients with perineal tumors. Histological examination led to a diagnosis of benign tumor (lipoma, granulomatous tumor) in two patients and a diagnosis of local perineal metastasis of a malignant nonseminomatous germ cell tumor in the third. After local tumor excision all patients stayed free of disease for 1-3 years. Neither physical nor clinical examination (standard blood parameters, ultrasound, X-ray of pelvis, urethrocystoscopy and rectoscopy) allowed determination before surgery of whether any of these perineal tumors was benign or malignant; percutaneous biopsy was the only way to find this out preoperatively. Radical excision of the perineal tumor is the treatment of choice. If extended dissemination has not taken place, malignant perineal tumors are curable by radical resection in nearly 80% of cases.

Adult↗
PubMed2002

Spindle cell lipoma-like tumor, solitary fibrous tumor and myofibroblastoma of the breast: a clinico-pathological analysis of 13 cases in favor of a unifying histogenetic concept.

We reviewed the clinico-pathological features of a series of 13 cases of benign spindle stromal tumors (BSSTs) of the breast relating to a basic common theme consisting of a well-circumscribed proliferation of vimentin+/CD34+/BCL-2+/CD99+ spindly to oval-epithelioid cells, variably arranged in haphazard to short fascicular growth pattern, with interspersed thick or thin collagen bands. Morphological variations included atypical mono- or multi-nucleated cells in five cases and a mature lipomatous tumor component, varying from focal to prominent, in eight cases. Based on morphological and immunophenotypical features, a distinction was made between two main subtypes of these tumors--fibroblastic and myofibroblastic. The former subtype included two cases respectively represented by a typical solitary fibrous tumor (SFT) and a neoplasm labeled "spindle-cell lipoma (SCL)-like tumor", closely reminiscent of soft tissue SCL. Both tumors had cells with fibroblastic-like appearance, haphazardly arranged and immunoreactive for vimentin, CD34, BCL-2, and CD99. The latter subtype, comprised nine cases exhibiting evidence of myofibroblastic differentiation (desmin and alpha-smooth muscle actin) which were classified as myofibroblastomas (MFBs). The remaining two cases were defined as "mixed BSSTs", having typical features of diverse neoplasms, respectively represented by a case of MFB with focal SFT and pleomorphic/SCL-like areas, and SFT with focal MFB-like component. The common basic morpho-immunophenotypical features, the possibility that both fibroblastic and myofibroblastic tumors may contain an additional mature lipomatous component, and the existence of hybrid stages (mixed BSSTs) strongly support the view that such tumors belong to the same category of lesions. We postulate that the precursor of all these neoplasms is the vimentin+/CD34+ cells of the mammary stroma, the well-known inherent plasticity of which to differentiate toward several mesenchymal lines, provides the explanation for the phenotypic heterogeneity of these neoplasms. Accordingly, the encompassing term "benign spindle stromal tumors of the breast" is advocated for such tumors.

12E7 Antigen↗
PubMed1980

Hormone responsiveness of the lipoma: a tumor of adipose tissue.

The ability of adipocytes from lipomas to respond to lipolytic stimuli was investigated to determine whether diminished responsiveness could account for the excessive accumulation of neutral lipid which characterizes these tumors. Baseline studies were performed on rat adipose tissues to determine optimal conditions for comparison of lipolytic responses to a variety of hormones. Cell concentrations, the specific depot site from which the cells are derived, the age of the animal and the tissue preparation, as to whether fragments are used as opposed to collagenase-treated isolated cells, were determined to affect the lipolytic response. When the response of lipomata adjusted per unit cell (DNA) are compared to unaffected cells adjoining the tumor, an enhanced lipolytic respnse to microM concentrations of l-epinephrine is seen in both fragments and isolated cells. These findings indicate that diminished lipolysis cannot account for the exaggerated storage of neutral fat in these tumors.

Adipose Tissue↗
PubMed2004

Lipoma-like tumor mass probably arising in the retroperitoneal heterotopic pancreas: a previously undescribed lesion.

Heterotopic pancreatic tissue is found in several locations of the body. However, to the best of our knowledge, there have been no reports on heterotopic pancreas in the retroperitoneum. A case of retroperitoneal lipoma-like large tumor mass probably arising in the heterotopic pancreas is reported. A 45-year-old Japanese woman was admitted to hospital because of back pain. Imaging modalities showed an abnormal mass in the retroperitoneum separate from the surrounding organs, including the pancreas and kidney. Histologically, the mass consisted of mature adipose tissue and scattered ductal and acinar elements. Although there was no islet tissue in this fatty mass, the epithelial elements suggested heterotopic pancreatic tissue in origin. The present case is very unusual; however, heterotopic pancreas should be considered in the differential diagnosis of retroperitoneal tumors.

Biomarkers, Tumor↗
PubMed1995

Chondroid lipoma, a tumor of white fat cells. A brief report of two cases with ultrastructural analysis.

Chondroid lipoma is a recently described variant of lipoma with unusual morphologic features. Although classified as a fatty neoplasm, its phenotype is uncertain because it has not been determined whether cartilage is a real component or only simulated by light microscopy and whether the adipocytes demonstrate white or brown fat differentiation, issues that can be resolved only by electron microscopy. We present two cases of chondroid lipoma that ultrastructurally showed abundant intracytoplasmic lipid and glycogen and numerous pinocytotic vesicles, characteristic of white adipocytes. These findings support the conclusion that these tumors are composed solely of fat without true cartilage differentiation.

Adipocytes↗