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At least 19 recordsLinked to original sources
PubMed1976

[The role of biopharmaceutical parameters in drug development (author's transl)].

The biopharmaceutical factors, which influence the interaction between dosage form and drug activity, extend from the mode of application, through chemical and physical properties of the active constituent, to the final product, including the excipients and manufacturing processes involved. In recent years, important strides have been made in this field, which improve drug safety. This has consequently influenced and enlarged the present scope of pharmaceutical technology drug research.

Biological Availability↗
PubMedDate not supplied

A contribution to the kinetics of dissolution of some modern drugs.

A report is presented on the investigation of some drugs being used in modern therapy from the point of view of dissolution kinetics in aqueous and in aqueous micellar solutions. It has been established that the dissolution (saturation) process, in accordance with previous assumptions, is kinetically of the first order both in aqueous and in aqueous micellar solutions. The rate constants describing these processes are nearly identical for the same drug, hence the saturation rates are nearly identical. The amount of drug dissolved within the unit of time decreases in the case of drotaverine and "RJ-64" in direct proportion to the concentration of the surfanctant, whereas in the case of the other drugs examined an increase occurred. The interpretation of the process for drotaverine and "RJ-64" needs further experimental clarification. The importance of kinetic concepts in pharmaceutical technology is emphasized.

Chemistry, Pharmaceutical↗
PubMed1978

Army technologists: 29-year follow up for cause of death.

A previous 18-year follow-up study revealed no significant excess of cancer among men who served in the Army during World War II as radiological technologists (n = 6,560) as compared with men who served as medical, laboratory, or pharmacy technologists (n = 6,826). Extension of the follow up by 11 years (1946-1974) revealed that 145 former radiological technologists had died of cancer, as compared with 158 controls. No statistically significant differences were found between these groups for individual sites of cancer or for deaths from other causes.

Follow-Up Studies↗
PubMed1977

Science and technology in the protection of human health and life.

Current trends in development of medicine related to advances in the technological sciences are discussed. Possibilities of cooperation of medicine and technology are reviewed, and ways of modernizing medical science and practice by utilizing achievements in this and other countries are pointed out.

Automation↗