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At least 19 recordsLinked to original sources
PubMed1991

Tin compounds inhibit the plasma cell response to metallic tin. Transfer of inhibition by parabiosis.

Injection of metallic tin powder causes intense proliferation of plasma cells in draining lymph nodes of Lewis rats. Pretreatment orally with soluble tin salts prevents this response to subsequently injected metallic tin. In the present work, pretreatment with tin salts by parenteral injection was just as effective as addition to the drinking water. This new approach made the following experiments possible. Poorly soluble tin compounds were found to be inhibitory when injected parenterally. Tin salts injected parenterally into one of two rats joined in parabiotic union prevented the plasma cell response to metallic tin in both parabionts. The transfer of the inhibitory effect via the cross-circulating blood represents significant progress toward understanding the mechanisms involved. The evidence suggests the possibility that tin salts elicit an intermediary substance or process that is responsible for inhibition of the plasma cell response to metallic tin.

Animals↗
PubMed1977

The chloride transport induced by triaklyl-tin compound across erythrocyte membrane.

The effect of tripropyl-tin chloride on anion permeability was studied using red cells previously treated with a covalent binding inhibitor 4-acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid (SITS) to inhibit completely and irreversibly the natural anion transport system. It was demonstrated that the tin compound can mediate chloride-hydroxide and chloride-chloride exchanges across the "impermeabilised" erythrocyte membrane. In the non hemolytic range, the rate of exchange increased with the concentration of the tin compound in a non linear fashion, and no saturation effect was seen. The temperature profile of the chloride self exchange induced by tripropyl-tin was studied and the apparent activation energy found was 29 Kcal/mol. The tripropyl-tin chloride cannot mediate a chloride-bicarbonate exchange. Because of this discriminatory effect between hydroxide and bicarbonate, the tin compound can be useful in certain experimental conditions as seen for the study of the anion "carrier" of the red cell membrane ("cousin, J.L., Motais, R. and Sola, F. (1975) J. Physiol. Lond. 253, 385-399).

Bicarbonates↗
PubMed1985

[Resistance to organic tin compounds mediated by plasmids of bacteria of Pseudomonas genus].

Resistance to organic tin compounds of P. aeruginosa and E. coli carrying antibiotic resistance plasmids and to P. putida containing biodegradation plasmids was studied. It was shown that 5 resistance plasmids and the biodegradation CAM plasmid of Pseudomonas increased 3-4 times the strain resistance to triethylstannylsuccinylimide and triethylstannylmaleinimide. All these plasmids belong to the P-2 incompatibility group and also determine the bacterial resistance to potassium tellurite. Isolation and investigation of the mutant plasmids loosing simultaneously the capacity for determination of resistance to potassium tellurite and organic tin compounds suggest that resistance to these compounds in the investigated plasmids is determined by the same genetic system.

Drug Resistance, Microbial↗