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At least 19 recordsLinked to original sources
PubMed1992

Current concepts of the biology of tooth eruption.

Tooth eruption is defined as the movement of a tooth from its site of development within the jaws to its position of function within the oral cavity. We present a critical review of evidence for the mechanisms and regulation of the intraosseous and supraosseous phases of eruption, with an emphasis upon the canine premolar model studied by the authors. Analyses at different stages of premolar eruption indicate that selective fragmentation of dental follicle protein DF-95 correlates with the presence of elevated levels of follicular collagenase and stromelysin, and with the onset of premolar movement. A dramatic decrease in these metalloproteinases followed initiation of movement. A biochemical and cell biological model for regulation of tooth eruption is proposed based upon these new and existing data.

Animals↗
PubMed1991

[Maturation of enamel and tooth eruption].

The tertiary maturation of the erupting tooth needs much more time than it is supposed in literature. Possibly the completion is in accord with the decline of the caries activity at the end of the second decade of lifetime. With the aid of polarizing microscopy, electron microprobe, microhardness testing (Vickers) and scanning electron microscopy different stages of posteruptive maturation from human and other mammalian teeth were analysed. The mineralization level in the outer surface of human enamel is completing little by little in more than 5 years after eruption. This state is in the ruminant tooth obvious never within reach in consequence of the specific physiological conditions. The maturating mineralization after our preliminary findings is fundamentally different to remineralization.

Animals↗
PubMed1992

The effects of colony-stimulating factor-1 on tooth eruption in the toothless (osteopetrotic) rat in relation to the critical periods for bone resorption during tooth eruption.

The toothless (tl) rat is an osteopetrotic mutation characterized by a generalized skeletal sclerosis, reduced bone resorption, few osteoclasts and a total absence of erupted teeth. This mutation is not cured by bone marrow transplants from normal littermates. It is known that the skeletal defects in tl rats are greatly improved after treatment with colony-stimulating factor-1 (CSF-1). This investigation concerns the effects of CSF-1 on the development and eruption of the dentition of tl rats. Untreated tl rats had no erupted teeth by 56 days after birth, and the roots of incisors and molars were severely distorted by compression against bone. The apex of the mandibular incisor did not extend past the first molar and continued growth of its apical end produced odontoma-like masses consisting of distorted dentine and enamel matrices. In addition, few osteoclasts were seen on alveolar bone surfaces surrounding the developing teeth. Mutants given CSF-1 were characterized by delayed eruption of all molars and sometimes incisors. The incidence of incisor eruption was related inversely to the age at which CSF-1 treatment began. Molars of treated tl rats had well-developed roots similar to those in normal rats. Treated mutants had numerous osteoclasts in alveolar bone and well-developed haemopoietic marrow spaces in the mandible. Histochemical staining for both tartrate-resistant acid phosphatase and tartrate-resistant acid ATPase was reduced or negligible in osteoclasts of untreated tl rats, heavy in normal osteoclasts and of intermediate intensity in CSF-1-treated mutants.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1992

Morphological and labeling evidence supporting and extending a modern theory of tooth eruption.

As the interest in biological mechanisms of tooth eruption has recently been revived by a new eruption theory, the present study was an attempt to contribute new data to this problem. Four male Macaca fascicularis monkeys, two infant (about 13 months old) and two juvenile (about 44 months old), were labeled either by sequential fluorochrome or by single 3H-proline injections and then served for studying the bone apposition patterns around erupting premolars and molars. About 100 microns thick ground sections cut either in the mesiodistal or bucco-oral direction and the corresponding micrographs, microradiographs and autoradiographs, as well as fluorescence micrographs were used. In the multirooted teeth studied, bone apposition was most prominent and fast in the inter-radicular region, while at the fundus of the alveoli, bone apposition was slight or negligible. Around maxillary premolars and molars, bone apposition pointed in the mesial as well as in the axial direction. This was true for the intraosseous and the supraosseous phase of tooth eruption. Using these observations in addition to preliminary data calculated for the rates of bone apposition in the inter-radicular, apical and crestal regions, and for the rate of root elongation, the new eruption hypothesis could be extended. It is suggested that eruption of multirooted teeth, in the presence of corresponding coronal resorption, is entirely explained by forces generated through inter-radicular bone apposition and that their dental follicle is in a stimulating mode inter-radicularly but neutral apically at the bottom of the alveolar fundus.

Animals↗
PubMed1992

Tooth eruption and orthodontic movement.

Teeth have been moved in man for centuries and the process of tooth eruption has occurred presumably since he evolved. The cellular and molecular mechanisms which are involved in these two phenomena are amongst the most intriguing questions in dental research today. The aim of this paper is to review some of the theories which have been proposed to explain the two processes. It is also intended to place in context the contribution being made by biological sciences, which might explain tooth eruption and tooth movement. It is not the intention to describe morphologic observations which are well documented and illustrated in more elaborate texts.

Bone Remodeling↗
PubMed1975

Nutritional status and the timing of deciduous tooth eruption.

The number of deciduous teeth in a sample of rural Ladino Guatemalan children was counted every 3 months through 24 months of age, and at 6-month intervals from 24 to 36 months. Nutritional status at birth, whether expressed as full-term birth weight or as maternal caloric supplementation during pregnancy, influences the timing of deciduous tooth eruption. Furthermore, the timing of deciduous tooth eruption seems more closely associated with postnatal weight than with birth weight. Although indices of nutritional deficiencies are associated with retarded tooth eruption, the use of mean number of deciduous teeth erupted as an estimate of mean chronological age in populations living under conditions of mild-to-moderate malnutrition is relatively accurate because errors of age estimation based on mean values for the present sample only vary between 1 and 2 months.

Birth Weight↗
PubMed1975

A note on the variation in the timing of deciduous tooth eruption.

A survey was carried out on the timing of deciduous tooth eruption based upon 3600 Caucasian children in three heterogeneous samples from Birmingham, Sheffield and Gloucester and a small more or less homogeneous sample from Biddulph (North Staffordshire). These data were compared with the eruption times derived from a sample of 600 British Negro children. Generally, the deciduous teeth of Negroes erupted before those of Caucasians, although the actual eruption times in each sample exhibited a greater degree of variability than is appreciated by most dental workers.

Age Factors↗
PubMed1978

The effect of chronic parathyroid extract on tooth eruption and dental tissues in osteopetrotic mice.

The grey lethal mouse is an osteopetrotic mutant in which there is diffuse sclerosis of the entire skeleton and the teeth remain trapped in the jaws. The condition was treated with daily subcutaneous injections of PTE beginning at birth. PTE induced molar tooth eruption in some mutants and improved root formation (without eruption) in others. However, the zone of predentine in the crown of the tooth remained abnormally wide and dentinogenesis remained irregular. Resorption of alveolar bone was adequate to permit complete tooth eruption in some animals and increased root formation in others.

Animals↗
PubMed1992

Localization of epidermal growth factor and its receptor in mandibular molars of the rat prior to and during prefunctional tooth eruption.

Immunoperoxidase localization of epidermal growth factor receptors (EGFR) and epidermal growth factor (EGF) itself was examined in rat first and second mandibular molars postnatally from day 0 to 12. The results showed that the dental follicle stained heavily for EGFR from day 0 to 8, declined in staining at day 9, and was devoid of stain from day 10 onward. Preosteoblasts and osteoblasts of alveolar bone also stained and lesser staining of ameloblasts and odontoblasts was observed. Except for staining of occasional isolated cells, the stellate reticulum did not stain. Light staining of the dental pulp of the first mandibular molar was seen from day 0 onward but the pulp of the second molar did not stain until approximately day 6. With respect to EGF, the dental follicle also stained for it until day 12. The ameloblasts stained more intensely for EGF than for EGFR. Because injections of EGF cause premature eruption of teeth and because the presence of a dental follicle is necessary for eruption, this study suggests that EGF could have its effect on the follicle as seen by the presence of EGFR receptors on the follicle. Moreover, because EGF exerts its effects early (day 0-3) to cause eruption and because the influx of monocytes into the follicle to form osteoclasts for bone resorption for eruption occurs early, the heavy staining for EGFR in the follicle early followed by the absence of staining at day 10 correlates chronologically with the key molecular and cellular events of eruption. Finally, the presence of EGF in the follicle, as well as enamel organ, could provide an endogenous source of EGF to regulate tooth eruption, either by an autocrine or a paracrine effect. Thus, the localization of EGFR and EGF in the dental follicle coupled with the chronology of localization suggests that EGF could play a physiological role in tooth eruption.

Animals↗
PubMed1977

Cyclic AMP in dental and periodontal tissues during tooth eruption in kittens.

Cyclic adenosine 3',5'-monophosphate (cAMP) concentrations and cellular distribution were studied in dental and periodontal tissues during tooth eruption in kittens. Although the mean levels of cAMP around developing teeth were similar in all the tissue samples, there were marked differences in cAMP stainability of tissues apical and occlusal to the erupting teeth.

Alveolar Process↗
PubMed1976

Tooth eruption and bone resorption: experimental investigation of the ia (osteopetrotic) rat as a model for studying their relationships.

The osteopetrotic (ia) rat was examined as an experimental model for studying the dependence of tooth eruption on bone resorption. In ia rats eruption of incisors and first molars was rare and eruption of second and third molars was reduced and delayed. Autoradiographic studies of 3H-proline incorporation showed that delayed eruption was not due to reduced tooth formation. Microscopic study revealed distortion and failure of posterior growth of the apical ends of incisors, unresorbed bone blocking the eruption pathway for molars, and ankylosis of incisors and first molars to alveolar bone. A reduction in bone resorption, known to be the primary cause of the disease in ia rats, is presumed to be the cause of the delayed or unerupted dentition. The effectiveness of attempts to increase bone resorption in ia rats at an early age by injection of vitamin A and/or parathyroid extract or by parabiotic union with a normal littermate was determined by measuring their effect on the relative size of the tibial marrow cavity. Only parabiosis had a beneficial effect on bone resorption but surgical union could not be performed in animals young enough to affect eruption of incisors and first molars in ia parabionts. These results suggest that parabiotic union of neonatal rats should allow resorption to begin early enough to test the presumed dependence of tooth eruption on bone resorption.

Animals↗
PubMed1991

Magnetostrictive calibration of a precision optical measurement device for studies of tooth eruption.

In order to calibrate a precision-measuring instrument for studies of tooth eruption, a calibration device capable of repositioning an optical grating in steps accurate to at least 0.02 microns was required. At this level, piezoelectric and similar pushers encounter problems. A new calibration device based on the magnetostrictive properties of nickel was developed. Accuracy better than 0.02 microns was verified by relating its movements to the wavelength of the green line of mercury, and the device was successfully used to calibrate the instrument for establishing tooth position. Magnetostriction offers a way to calibrate precision measurement instruments for other applications.

Bicuspid↗
PubMed1992

Mandibular growth and tooth eruption after localized x-radiation.

The effect of localized x-radiation on the growth of mandibular bone and molar eruption was evaluated by morphometric methods. A dose of 20 Gy of x-radiation was given to the molar zone of growing rats. The animals were then killed in groups at 30 and 60 days postirradiation. Two groups of nonirradiated, age-matched rats were used as controls. Parameters related to molar eruption, mandibular length, and mandibular height were measured on lateral radiographs. The results obtained showed that the values of the biometric parameters were lower in experimental than in control animals. Odontoblastic atrophy, alveolodentary ankylosis, and meager or no root formation were the most conspicuous histologic findings. Osteodentin was found between canaliculary dentin and bone in cases of ankylosis. The morphometric data presented confirm the probability of alterations in mandibular growth and tooth eruption following x-radiation and suggest that this be considered in planning radiotherapy in children.

Alveolar Process↗