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Results for “Trimeprazine”

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14 recordsLinked to original sources
PubMed1977

Controlled clinical investigation of trimeprazine as a sleep-inducer in normal subjects.

The effects of acute introduction and withdrawal of trimeprazine (Vallergan), an antihistaminic phenothiazine derivative with known sedative effects, were investigated by a single blind polygraphic study in 8 healthy volunteers. A baseline placebo was given on Nights 1-3, followed either by 10 mg or 20 mg of the drug on Nights 4-6, and then withdrawal effects were recorded on Nights 7-9. The subjective effects of the drug and EEG sleep variables were determined on these nights. The results showed that the drug might have had dose related effects. REM-sleep was increased by 10 mg doses, which also caused an increase in SW sleep. There was no significant change after the 20 mg dose. Significant REM rebound was not observed after withdrawal of either dose. These characteristics may be of value in the treatment of certain aspects of sleep disturbances.

Adult↗
PubMed1979

Effects of trimeprazine and trimipramine on nocturnal scratching in patients with atopic eczema.

Twelve men with severe and long-standing atopic eczema were admitted to a double-blind trial to establish the effects of trimeprazine tartrate, trimipramine maleate, and placebo on nocturnal scratching. Neither of the drugs altered the likelihood of a scratching bout beginning in wakefulness or in any stage of sleep. However, both drugs, especially trimipramine, made sleep less broken, and the reduced time spent in stage 1 of sleep accounted for a modest reduction in the overall amount of scratching during the night.

Adult↗
PubMed1979

Elimination of F'lac plasmid by different psychotropic drugs and some related compounds.

Desipramine, trimipramine, protriptyline, noxiptyline, promazine, trimeprazine, triflupromazine and chlorprothixene methoiodide eliminated the F'lac plasmid of Escherichia coli, while thiazinanum, toluidine blue, lidocaine and procaine were ineffective in this respect. The plasmid eliminating action of the drug ceased in the presence of 0.05 M magnesium sulphate. Methylene blue did not inhibit plasmid elimination by the psychotropic drugs, and in presence of the dye even lidocaine and procaine became effective. Based on plasmid elimination in the presence of methylene blue and on the selective effects of the lon- mutant, the plasmid eliminating mechanism of psychotropic drugs seems to differ from that of acridine orange.

Animals↗
PubMed1979

[Preoperative arrhythmias in ophthalmological surgery].

Continuous ECG recording (Holter technique) was carried out in 25 patients undergoing similar ophtalmological surgery for retinal detachment. The patients were selected at random and divided into two groups. Premedication (alimemazine 25 mg. atropine 0.5 mg given one hour before the operation) and induction (penthiobarbital 4 mg.kg-1 and succinylcholine iodide 1 mg.kg-1) were given in the same way. General anaesthesia was maintained in Group I (n = 12) with halothane and in group II (n = 13) using neuroleptanalgesia. There was no significant difference in the percentage of arrhythmias between the two groups. There was a remarkablly high prevalence of sinus bradycardia and ventricular pauses (8/25). The respective role of atropine and of retrobulbar local anaesthesia in prevention is discussed in the light of data from the literature. If arrhythmias occurring at the time of intubation are included, the total percentage of rhythm disturbances was 80 p. 100 (20/25).

Arrhythmias, Cardiac↗