Avian tuberculosis.
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A case of avian tuberculosis in a horse, with fatal course, is reported. The animal was imported from Poland and became ill after some weeks, in the beginning showing non-specific symptoms which became more severe until death supervened. Post-mortem examination showed a generalised form of tuberculosis. The most important lesions were seen in the lungs, liver, kidneys, spleen, intestinal tract, bones, bone marrow, and the internal lymph nodes. Beside chronic proliferative tuberculosis of the organs, many exudative foci were found with remarkably abundant acid fast bacilli. Mixed lesions were seen, too. Mycobacterium avium was isolated in microbiological examination. The pathogenesis of the infection, the predisposing factors leading to this generalised and open form of tuberculosis and the increasing importance of avian tuberculosis for animals and man are discussed.
The leading role of wild birds in the spread and circulation of the causative agent of avian tuberculosis is emphasized and the basic theoretical prerequisites of developing the hypothesis of the formation of its natural foci are discussed. The significance of the individual factors for the formation of the theory of natural foci of tuberculosis caused by M. avium is displayed. The opinion is expressed that avian tuberculosis should be classified among facultatively transmissible natural-focal infections in the epizootic process of which both transmissive (ticks) and non-transmissive (water; various infected substrates, soil, etc.) factors take part.
An outbreak of tuberculosis caused by Mycobacterium avium type 2 is described which resulted in the total condemnation of 26 carcasses and partial condemnation of tissues and organs of a further 200 animals. Circumstantial evidence is presented that hens running in the farmyard were the source of the infection. Examinations of the carcasses and organs of the diseased pigs suggested that the accepted pathogenesis of the disease is incorrect and a new hypothesis is presented. The problems for the meat inspector in differentiating tuberculosis from 'milk-spot liver' are discussed and recommendations made. The findings of the study are discussed in the light of 'The Meat Inspection Regulations 1963' and it is recommended that where tuberculosis is suspected there is no longer any necessity to split the carcasses. The public health implications of this study are discussed.
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A tubercular lesion (15 mm in diameter) was found on the skin of the caudal part of the cloaca in a 2-year-old male carrier-pigeon. Mycobacterium avium serovar 2 was isolated from the tubercular lesion on the skin and in the feces. The smooth and dome (SmD) variant (4.9 x 10(6) CFU) and rough and granular (RG) variant (3.7 x 10(7) CFU) of the isolates were injected into chickens intravenously. The chickens inoculated with the RG variant died on the 39th day and the one with the SmD variant died on the 77th day after inoculation. Enlargement of the liver and spleen was observed in all the inoculated chickens. Many white tubercular lesions were observed in the liver, spleen and lung of the chicken inoculated with the SmD variant, while no macroscopical change was observed in the bird inoculated with the RG variant. Inoculated organisms were recovered from the liver, spleen, kidneys, lungs and pancreas of each inoculated chicken.
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Mycobacterium avium was isolated from 82 of 11,664 birds submitted for necropsy in The Netherlands. All isolated M. avium strains belonged to serotype 1, 2 or 3. The greatest number M. avium were from buzzards and falcons. The prevalence of tuberculosis in gulls is extremely low.
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