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At least 19 recordsLinked to original sources
PubMed1989

Inhibition of endotoxin-induced bacterial translocation in mice.

The primary functions of the gut are to absorb nutrients and exclude bacteria and their products. However, under certain circumstances the gut may lose its barrier function and serve as a reservoir for systemic microbial infections. These experiments were performed to determine the mechanisms whereby endotoxin causes bacteria to escape (translocate) from the gut. Bacteria translocated from the gut to the mesenteric lymph nodes of mice challenged with nonlethal doses of Escherichia coli 026:B6 or E. coli 0111:B4 endotoxin. Physical disruption of the gut mucosal barrier appears to be the primary mechanism whereby endotoxin promotes bacterial translocation. Mucosal injury and endotoxin-induced bacterial translocation were reduced by inhibition (allopurinol) or inactivation (tung-sten diet) of xanthine oxidase activity (P less than 0.01), but were not affected by the platelet-activation factor antagonists, SRI 63-441 or BN 52021. Because the inhibition or inactivation of xanthine oxidase activity reduced both the extent of mucosal injury and endotoxin-induced bacterial translocation, the effect of endotoxin on the gut appears to be mediated, at least to some degree, by xanthine oxidase-generated, oxygen-free radicals.

Allopurinol↗
PubMed1989

Inhibitory effects of sulphur compounds, copper and tungsten on nitrate reduction by mixed rumen micro-organisms.

1. The inhibitory effects of inorganic and organic sulphur-containing compounds, copper and tungsten on nitrate reduction by mixed rumen micro-organisms were investigated in two in vitro studies. 2. Coarsely strained rumen fluid from nitrate-adapted (Expt 1) or non-adapted (Expt 2) Suffolk Down wethers maintained on lucerne (Medicago sativa) cubes was used as an inoculum. In Expt 1, anaerobic incubation was carried out for 24 h for each medium supplemented with 10 mM-sodium nitrate and the following chemicals: 0, 1, 2, 3, 5, 8 and 10 mM-sodium sulphide, 1 and 10 mM-sodium sulphite, 1 and 10 mM-sodium sulphate, 1 and 10 mM-L-cysteine, 1 and 10 mM-DL-methionine, 1 mM-sodium tungstate and 1 mM-copper sulphate. In Expt 2, 1 and 10 mM-Na2S, 1 and 10 mM-L-cysteine, 1 mM-Na2WO4, and 1 mM-CuSO4 were added to incubation media to test for chemical inhibition of microbial reduction of nitrate. 3. In Expt 1, the amount of nitrite formed decreased with increasing concentration of sulphide-S added. The additions of L-cysteine, W and Cu suppressed nitrite formation in media from both nitrate-adapted and non-adapted sheep. 4. In contrast to the effects of sulphide, L-cysteine and W counteracted, to some degree, nitrate-induced reduction of volatile fatty acid (VFA) production. Addition of Cu to the media resulted in a further depression of VFA production.

Animals↗
PubMed1990

[Combinations of borotungstic acid with nitrogenous compounds].

On combinations of borotungstic acid with nitrogenous compounds. Under definite conditions, these combinations are borotungstates of quinine, cinchonine, cinchonidine, brucine, strychnine, morphine, sparteine, pilocarpine, nicotine, stovaine, procaine, choline and acetylcholine. Their composition is probably variable according to the pH (ex.: procaïne).

Acid-Base Equilibrium↗
PubMed1992

27Al and 23Na double-rotation NMR of sodalites.

The 27Al NMR spectra of calcium tungstate aluminate sodalite (CAW), Ca8[Al12O24](WO4)2, and the 23Na NMR spectra of sodium aluminosilicate sodalites of general composition Na9[Si6Al6O24]A2 with A = B(OH)4- (SBS), SCN- (SRS) and A2 = SO4(2-) (SSS), MoO4(2-) (SMS) have been measured using magic-angle spinning (MAS) and double-rotation (DOR) techniques. Rotor synchronized pulse excitation is applied in the DOR experiments. Dramatic line narrowing is observed in the DOR spectra of all samples. The 27Al DOR NMR spectra of CAW measured at 9.4 and 11.7 T and spinning rates of 800-1150 Hz of the outer and 5 kHz of the inner rotor show seven sharp central lines accompanied by a manifold of spinning sidebands. These lines correspond to the seven crystallographically inequivalent Al sites of the CAW framework derived from X-ray structure analysis. From the difference of the line positions in the 9.4 and 11.7 T spectra the quadrupole coupling constant, QCC, quadrupole induced shift, sigma qs, and isotropic chemical shift, delta cs, of each Al site have been calculated. QCC values in the range of 5 to 9 MHz are obtained which reflect the strong tetragonal distortion of the AlO4 tetrahedra in CAW. delta cs shows only small changes in the range between 74.4 and 77.2 ppm. A tentative assignment of all lines to the distinct Al sites is derived from the correlation between QCC and a "shear strain parameter" describing quantitatively the distortion of the AlO4 tetrahedra.(ABSTRACT TRUNCATED AT 250 WORDS)

Aluminum↗
PubMed1988

Exposure reduction in cephalometric radiology: a comprehensive approach.

Various methods have been proposed and investigated for the purpose of reducing radiation exposures in cephalometric radiography. The purpose of this investigation was to use various dose-reducing methods from four major categories--(1) rare-earth intensifying screens, (2) rare-earth filtration, (3) prepatient soft-tissue enhancement methods, and (4) films varying in speed and latitude--to determine optimal combinations on the basis of exposure reduction and image quality achieved. In laboratory tests and clinical trials, radiation doses were compared along with various tests of image quality for the standard system currently used at this institution and for experimental systems. Image quality was assessed by standard panel-of-expert methods and more quantitative methods involving optical densitometry, contrast indices, and landmark envelopes of error. Results demonstrated that significant exposure reductions were achievable, often with improved image quality. The degree of exposure reduction was dependent largely upon the type of intensifying screen and to a lesser extent on beam filtration or film types. The greatest reduction in exposures were achieved with techniques using rare-earth beam filtration. Image quality was highest with a new wide-latitude type film. Because such significant reduction in radiation exposure for cephalometrics is possible with new techniques, we conclude that a change from the previous standard should occur. In establishing a new technique, orthodontists should consider adopting rare-earth screens and beam filters, flat-grained films, prepatient soft-tissue enhancement methods, and the elimination of grids.

Calcium Compounds↗
PubMed1979

X-ray absorption, speed, and luminescent efficiency of rare earth and other intensifying screens.

Seven new and two conventional screens were investigated. Measurements were performed at different energies of the photon fraction interacting in the screens, and energy losses due to escape of K-fluorescent radiations were calculated. The speed of the screens was dependent on the energy; this was primarily due to the fact that x-ray absorption is dependent on energy. Rare earth and other new screens absorb a maximum of 1.5 times as much energy and emit twice as much light as comparable calcium tungstate screens. Reabsorbed K-fluorescent radiations might contribute to image unsharpness in the new screens.

Calcium Compounds↗
PubMed1989

Behavior of [185W]thiotungstates injected into sheep and the influence of copper: their fate and the effect of the compounds upon plasma copper.

[185W]trithio- and tetrathiotungstates (0.5 mg W) were injected intravenously into sheep. The compounds circulated in plasma bound reversibly to plasma proteins, particularly to albumin. After the first few minutes, levels declined exponentially with a T 1/2 of 12-14 hr. The initial movement of [185W]trithiotungstate from the plasma compartment was delayed transiently by the immediate injection of copper (2-6 mg); the longer-term metabolism was unaffected. The final fate of the compounds appeared to be hydrolysis and excretion in urine as [185W]tungstate. 185W from [185W]trithiotungstate appeared more rapidly than from [185W]tetrathiotungstate, but in both the rate was unaffected by copper injections. Since the appearance in urine did not correspond to the disappearance from plasma, it was suggested that the hydrolysis occurred in extravascular tissues and that the liver might be the site. A control experiment showed that [185W]tungstate in plasma was very rapidly cleared (and appeared in urine). At higher W levels (25-50 mg W per sheep per day), systematic copper metabolism was perturbed since plasma copper levels rose. The experiments demonstrated that in sheep the behavior and the effects of thiotungstates and thiomolybdates are sufficiently similar for 185W to be used as a more convenient alternative to 99Mo for longer-term studies on the interaction of the compounds with copper metabolism in animals.

Animals↗
PubMed1989

A clinical comparison of image quality and patient exposure reduction in panoramic radiography with heavy metal filtration.

Laboratory and clinical studies with the use of rare earth intensifying screens and four different forms of heavy metal elements serving as additional beam filtration were performed for panoramic radiography to identify the most efficacious system. Balanced density images were evaluated for contrast indices, resolution, relative dose reduction, and subjective image quality. Clinical studies were performed with a standard calcium tungstate imaging system and the four most promising experimental imaging systems that showed improvement over the standard system. Dosimetric studies were performed with the use of ionization chambers and thermoluminescent dosimetry (TLD) dosimeters. Exposure reductions of 34% to 79%, depending on the anatomic site and the imaging system used, were achieved. Subjective image quality was evaluated and analyzed statistically. This study concluded that the use of a Kodak Lanex regular screen/T-Mat G film with either Lanex screen or yttrium added beam filtration results in reduced patient exposure in panoramic radiography while image quality is maintained or improved.

Calcium Compounds↗
PubMed1990

Evaluation of rare earth intensifying screens in cephalometric radiography.

Accuracy of cephalometric landmark location was determined in 20 pairs of headfilms, measuring differences in 18 points in two planes of each, using five independent observers. Each pair had one film taken with a conventional (calcium tungstate) intensifying screen system and one taken with a rare earth system. Statistically significant differences in accuracy were found in only six of the 36 measurements. Three of the differences favored the accuracy of the rare earth system (Pogonion Y, S Pogonion X and Y), while the other three favored the conventional system (ANS-X, Nasion-Y, Pt.A-Y). The least reproducible point in both systems in the horizontal axis was condylion. Since these findings showed no landmark accuracy preference of one screen system over the other, the 96 percent reduction in patient radiation with the rare earth system would mandate this be used in cephalometric radiography.

Calcium Compounds↗
PubMed1988

[Evaluation of intraocular metallic foreign bodies by multi-element neutron activation analysis].

Multi-element neutron activation analysis method was applied to the determination of metallic foreign bodies which penetrated into the eyes of workers while engaged in grinding and cutting work. A total of 23 small pieces ranging in size from 1 to 10(2) mg were surgically obtained and then analyzed non-destructively with only simple washing treatment. The components of 21 samples were mainly iron and the others were hard pieces of wolfram compound. Elements determined in samples over one weight percent were iron, manganese, chromium, wolfram, and cobalt. All the samples were divided into five classes according to their own elemental composition. It was considered that foreign bodies were composed of carbon steel, steel alloy, and tungsten carbide. These results are regarded to be useful in studying the mechanism of accidents and their effects on eyes.

Eye Foreign Bodies↗
PubMed1992

Suppressive effect of polyoxometalates on the cytopathogenicity of human immunodeficiency virus type 1 (HIV-1) in vitro and their inhibitory activity against HIV-1 reverse transcriptase.

One isopolyoxometalate and 42 heteropolyoxometalates consisting of 3 compounds with the trivacant Keggin structure, 2 with the lacunary Keggin structure, 30 with the Keggin structure, one with the Wells-Dawson structure and 6 with miscellaneous structures were tested for their suppressive effect on the cytopathogenicity of human immunodeficiency virus type 1 (HIV-1) in vitro and inhibitory activity against HIV-1 reverse transcriptase. In contrast to the leading interpretations which attribute the suppressive effect of polyoxometalates on the cytopathogenicity of HIV-1 to the inhibition of HIV-1 reverse transcriptase by these compounds, there was no distinct correlation observed between these two functions of polyoxometalates.

Antimony↗
PubMed1990

Anti-HIV-1 activity, toxicity, and stability studies of representative structural families of polyoxometalates.

The anti-HIV-1 activity and toxicity of representative structural families of polyoxotungstates in human lymphocytes was determined. The 21 compounds examined include those derived from the following structural families: [NaSb9W21O86]18- (HPA-23), Xn+W12O40(8-n)- (Keggin), P2W18O62(6-) (Wells-Dawson), W6O19(2-) (Lindqvist), [NaP5W30O110]14- (Preyssler), and W10O32(4-) (decatungstate). The molecular architecture of each of these structural families is constituted principally by a network of bonds between d0 WVI and oxide ions. Of these, 10 show median effective concentration (EC50) values of approximately 1 microM and six have marked toxicity with a median inhibitory concentration (IC50) of less than 50 microM. Only compounds containing more than six metal atoms showed appreciable antiviral activity. Beyond this, however, no marked correlation existed between the molecular size, charge, or charge density of the polyoxometalates and their anti-HIV-1 activity. Examination of an exemplary class of polyoxotungstates, the phosphotungstates of formula A- and B-PW9O34(9-) under physiological conditions (buffered neutral aqueous media), illustrates that both isomers equilibrate rapidly to generate the same distribution of products and that this distribution depends principally on the buffer. These heretofore unappreciated complexities in the chemistry of these compounds under neutral aqueous conditions indicates interpretation or evaluation of these compounds in cell culture and other biological screens must be done with care.

Antimony↗