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At least 19 recordsLinked to original sources
PubMedDate not supplied

[Urinary uropepsin activity in patients with different forms of stroke].

The investigations were carried out in 30 control cases, in 20 patients with acute transient cerebral circulatory failure, 20 patients with intracerebral haemorrhage, and 22 patients with thrombotic encephalomalacia. The determinations of uropepsin activity were done on the 1st, 3rd, 7th and 14th days of the disease. Uropepsin activity in 24-hour urine was determined by the method of West, Ellis and Scott. In the group of patients with acute transient cerebral circulatory failure abnormalities in urinary uropepsin activity were not significant. The mean activity of uropepsin in 24-hour urine in patients with intracerebral haemorrhage and brain infarction on the 1st day of the disease was significantly higher than in controls. The rise in the activity of this enzyme in patients with encephalomalacia was lower in relation to patients with intracerebral haemorrhages. During improvement of the condition of patients with brain stroke the uropepsin activity in 24-hour urine decreased.

Acute Disease↗
PubMed2001

Molecular model for the binary complex of uropepsin and pepstatin.

The three-dimensional structure of human uropepsin complexed with pepstatin has been modelled using human pepsin as a template. Uropepsin is an aspartic proteinase from the urine, produced in the form of pepsinogen A in the gastric mucosa. The structure is bilobal, consisting of two predominantly beta-sheet lobes which, as observed in other aspartic proteinases, are related by a pseudo twofold axis. A structural comparison between binary complexes of pepsin:pepstatin and uropepsin:pepstatin is discussed.

Binding Sites↗
PubMed1975

[Uropepsin change in peptic ulcer after balneological treatment at Khisar].

The author followed uropepsin in ulcer patients before and after a complex balneo-therapy in Hissar, where the following therapeutic complex was applied: 1) Tub bath--36-38 degrees C; 2) Drinking of mineral water--"Momina Sălsa" spring (slightly mineralized, hydrocarbonate-sodium, slightly radioactive, fluor). Diet No 1 and physical excercises in hyperacidity. The author has established two-way changes in the values of the followed-up uropepsin, the high--decreased and the low--increased to normalization. The resulsts are statistically significant. Concluding he admits that uropepsin is a reliable method for investigation of the fermetformation function of gastric mucosa and for the assesment of the balneotherapy effect in sanatorium conditions.

Adult↗
PubMedDate not supplied

[Urinary uropepsin activity in patients with encephalomalacia as an index of the activity of the hypothalamo- hypophyseal-adrenal axis].

The determinations were carried out in 25 patients with thrombotic encephalomalacia. The changes in 24-hour urine uropepsin activity were studied after administration of metopirone and dexamethasone. The uropepsin activity in a sample of 24-hour urine was determined by the method of West, Ellis and Scott. A statistically significant fall of uropepsin activity was observed in 24-hour urine after metopirone, with a rise in the activity of this enzyme after dexamethasone administration.

Aged↗
PubMed2001

Structure of human uropepsin at 2.45 A resolution.

The molecular structure of human uropepsin, an aspartic proteinase from the urine produced in the form of pepsinogen A in the gastric mucosa, has been determined by molecular replacement using human pepsin as the search model. Crystals belong to space group P2(1)2(1)2(1), with unit-cell parameters a = 50.99, b = 75.56, c = 89.90 A. Crystallographic refinement led to an R factor of 0.161 at 2.45 A resolution. The positions of 2437 non-H protein atoms in 326 residues have been determined and the model contains 143 water molecules. The structure is bilobal, consisting of two predominantly beta-sheet lobes which, as observed in other aspartic proteinases, are related by a pseudo-twofold axis. A model of the uropepsin-pepstatin complex has been constructed based on the high-resolution crystal structure of pepsin complexed with pepstatin.

Amino Acid Sequence↗
PubMed1980

[Changes in urine vitamin C, creatinine and uropepsin levels as a result of workload at standard work stations in the shipyard].

In 30 randomly selected workers at standard shipyard work-stations, energetic expenditure was estimated by comparing the results with those of biochemical tests used for evaluating the workload degree, such as: creatinine and vitamin C content in urine, uropepsin activity, degree of saturating the organism with vitamin C. The same examinations were carried out in 20 auxiliary and administrative employees composing a control group. The results demonstrate decreased vitamin C level in urine and saliva towards the end of the working day in the productive" group (the one under examination) as compared to the control one." The total creatinine level and uropepsin activity were also enhanced in the urine of the productive workmen. The differences between the mean values between the examined and control groups were statistically significantly different. A correlation was found between the energetic expenditure and changes in the mentioned biochemical parameters in urine.

Ascorbic Acid↗
PubMedDate not supplied

[Urinary uropepsin activity in patients with closed cranial trauma].

The authors determined uropepsin activity in 24-hour urine in 30 cases of mild craniocerebral trauma. The determinations were done on the 1st, 3d and 7th days after trauma. The control group consisted of 15 healthy subjects. The activity of the enzyme was raised only on the 1st day after trauma and it may be explained as a result of stress.

Adolescent↗