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At least 19 recordsLinked to original sources
PubMed1977

Effect of ultraviolet light therapy, given over a period of several weeks, on the amount and composition of the skin surface lipids.

Ultraviolet (UV) light therapy was given over a period of several weeks to 19 test persons on one side of the back. The duration of the treatment was gradually increased from 30 sec to 7 min. After conclusion of the treatment quantitative lipid determination was made on both the treated and the untreated sides of the back, using the direct extraction method and the paper absorption method. The lipids obtained in this way were analysed by thin-layer chromatography. The following were the most important results: (1) The amount of skin surface lipids was significantly increased by UV irradiation. This results goth from an increase in the epidermal lipids as well as in the lipids of the sebaceous blands. (2) The percentage of free cholesterol in the skin surface lipids was significantly increased by UV irradiation. This increase is probably connected with a thickening of the stratum corneum. (3) The percentage of free fatty acids in the skin surface lipids is significantly increased by UV therapy. This shows that the living conditions of the saprophyte skin flora, which set free lipases, are improved as a result of this treatment or that this treatment leads to an increase of the activity of the bacterial lipases in the excretory ducts of the sebaceous glands.

Adult↗
PubMedDate not supplied

[Basic principles of physiotherapy for allergic diseases of the otorhinolaryngologic organs].

Physiotherapy for allergic diseases of otorhinolaryngeal organs is often practiced without taking into consideration the stage of development of the pathologic process, its form and individual peculiarities of its course. This is partly connected with lack of data on the mechanism of the hyposensibilizing effect of physiofactors. In this paper the authors divide the methods of hyposensibilizing physiotherapy into groups according to their prevalent effect on the particular system taking part in the formation of clinical manifestations of the allergic reaction. The authors discuss the expediency of using each group of methods at various stages of the disease according to its form and individual peculiarities of its course.

Histamine H1 Antagonists↗
PubMed1978

[Use of physical therapy in the prevention and treatment of decubitus ulcer].

The causes of bedsores and their complications are described, along with the preventive and surgical, medical and physiotherapeutic measures used in their treatment. Personal experience with an association of drugs and physiotherapy in 21 cases is reported and the modalities employed are described in detail. The advantages offered by the association in the way of simplicity and satisfacory results are explained.

Adult↗
PubMed1979

6-Thioguanine resistant peripheral blood lymphocytes in humans following psoralen, long-wave ultraviolet light (PUVA) therapy.

A recently described method that enumerates variant 6-thioguanine resistant peripheral blood lymphocytes present in vivo in man as a potential marker of somatic cell mutations occurring in vivo was used to study 18 psoriatic patients receiving PUVA therapy, 16 conventinally treated psoriatic patients, 10 vitiligo patients receiving PUVA therapy and 7 untreated individuals with vitiligo. Variant lymphocyte frequencies determined for these individuals were compared with those determined for groups of 10 concurrent and 63 cumulative healthy control individuals. Variant frequencies were elevated in psoriatic and vitiligo patients receiving PUVA therapy and in conventionally-treated psoriatic patients. They were not elevated over control values in untreated vitiligo patients.

Adult↗
PubMed1992

A reappraisal of the use of 5-methoxypsoralen in the therapy of psoriasis.

5-methoxypsoralen (5-MOP) is considered an alternative to 8-methoxypsoralen (8-MOP) for photochemotherapy of psoriasis. We have compared the clinical efficacy and tolerability of 5-MOP (1.2 mg/kg)-UVA versus 8-MOP (0.6 mg/kg)-UVA therapy in 25 patients of skin type III and IV, affected by relapsing plaque-type psoriasis of similar body involvement; indeed, the same patients were given 8-MOP during 1 year and 5-MOP during the subsequent year after relapsing. Both treatments cleared psoriatic lesions with a comparable number of exposures, but 5-MOP required significantly higher cumulative UVA doses. The difference was due to the lower phototoxicity of 5-MOP, as assessed by the determination of the minimal phototoxic dose, and to its higher tanning activity, as assessed by the weekly grading of pigmentation. Nevertheless, therapy by 5-MOP-UVA seemed particularly interesting in that it showed a higher tolerability since only 1 patient experienced nausea, whereas during therapy with 8-MOP-UVA nausea and/or vomiting occurred in 7 patients, sunburn in 6 and itching in 3. Since we have treated the same patients with the two drugs, our results were not influenced by interindividual variations of phototoxic responses, tanning ability and susceptibility to develop psoralen-induced short-term side-effects. It was concluded that, although long-term side-effects of the 5-MOP-UVA treatment have still to be determined, such treatment of psoriasis should be reappraised due to its higher tolerability in comparison to 8-MOP-UVA treatment.

5-Methoxypsoralen↗