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Results for “Unilateral Breast Neoplasms”

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At least 19 recordsLinked to original sources
PubMed2026

Integrating Genomic and Nongenomic Data to Stratify the Risk of Contralateral Breast Cancer After Radiation Therapy.

PURPOSE: Women treated with radiation therapy (RT) for breast cancer have an increased risk of developing radiation-associated contralateral breast cancer (CBC). Predicting CBC events is challenging because of the complex interplay of genomic, treatment, personal, and clinical factors. This study investigated computational methods that integrate genome-wide single-nucleotide polymorphisms and nongenomic data to develop a risk stratification model for developing CBC in women treated with RT for their first primary breast cancer. METHODS AND MATERIALS: This study used a subset of the population-based Women's Environmental Cancer and Radiation Epidemiology study that included 633 CBC cases and 1253 individually matched unilateral breast cancer controls who were treated with RT and had single-nucleotide polymorphism data available from a genome-wide association study. The study population was split into training, validation, and test sets for rigorous modeling and validation. Three data integration methods were compared in terms of their ability to stratify CBC risk: (1) naive integration; (2) sequential integration; and (3) sequential iterative integration. A biological analysis of the final model was performed using gene set enrichment analysis and protein-protein interaction analysis with gene annotation information informed by the model. RESULTS: The best-performing integration method was the sequential iterative integration equipped with the mixed-effect random forest algorithm. This approach achieved an area under the curve of 0.64 to stratify CBC risk in the test set, representing moderate predictive power. Calibration analysis showed good agreement between the lowest and highest risk bins stratified using sorted predicted values in the test set, resulting in an odds ratio of 3.27 for both predicted and observed CBC occurrence. Gene set enrichment analysis and protein-protein interaction analysis revealed that genes with high importance scores were associated with pathways relevant to lipid and fatty acid metabolism as well as breast cancer sensitivity to tamoxifen. CONCLUSIONS: The mixed-effect random forest approach demonstrated the potential for integrating high-dimensional genomic and low-dimensional nongenomic data to stratify CBC risk.

Humans↗
PubMed1992

Metastatic hepatocellular carcinoma of the breast, simulating gynecomastia: diagnosis by fine-needle aspiration biopsy.

Hepatocellular carcinoma (HCC) may uncommonly present with distant metastasis in the absence of a documented neoplasm in the liver. The authors herein describe the case of a 60-year-old man with cirrhosis who developed unilateral enlargement of the breast and a subareolar mass. This problem was clinically thought to represent gynecomastia, but a mammary fine-needle aspiration biopsy demonstrated a malignant epithelial neoplasm composed of large granular amphophilic cells. Bile pigment was visualized in the tumor on aspirate smears and cell block preparations; immunostains showed reactivity for cytokeratin and alpha-fetoprotein, but there was no positivity for epithelial membrane antigen, gross cystic disease fluid protein-15, vimentin, estrogen receptors, progesterone receptors, or S100 protein. These results indicated a diagnosis of metastatic HCC, which was subsequently confirmed by computed tomography of the abdomen.

Biomarkers↗
PubMed1979

[Differential diagnosis of gynaecomastia in the mammogram (author's transl)].

The purely clinical examination of swelling in the region of the male mammary gland involves a high error quota and must, therefore, be supplemented by other methods. Mammography has proved to be a reliable diagnostic method in the differential diagnosis of diseases of the mammary gland in the male; this method is of great importance in a positive sense as well. Gynaecomastia, with its typical criteria, must first of all be excluded. This enables the doctor to differentiate between various forms of gynaecomastia and to classify them into a kind of scheme. In all patients over 25 years of age, a carcinoma must be suspected particularly in case of a unilateral finding.

Adolescent↗
PubMed1977

Tubular carcinoma of the breast. Clinical, histological, and ultrastructural observations.

Tubular carcinoma is a neoplasm with good prognosis of features that warrant its differentiation from other mammary carcinomas and from sclerosing adenosis. Cases of nine primary unilateral neoplasms are presented and ultrastructural observations in three discussed. The mean diameter was 1.2 cm and the mean patient age was 48.7 years. None of the patients died and only one of six had residual tumor in the mastectomy specimens. Three patients had an excisional biopsy, one followed by radiation. All biopsy specimens showed infiltrating angular tubules with single-lining epithelium, minimal anaplasia, rare mitosis, and scant or absent myoepithelium. The tumor cells related to each other by desmosomes, cytoplasmic interlocking processes, and tight junctions. Myoepithelial cells were rare. Since tubular carcinomas are distinct variety of ductal epithelial neoplasms of the breast, and are well differentiated with low malignant biological behavior, a less radical approach may be the treatment of choice.

Breast↗
PubMed1978

Intrathoracic lymph node metastases from extrathoracic neoplasms.

The clinical records of 1,071 cases of extrathoracic malignant neoplasms seen over a 2 year period sere reviewed: 163 had abnormal chest films, and 25 of these showed evidence of mediastinal and/or hilar lymph node metastases. The primary malignancies which metastasized to intrathoracic lymph nodes included eight tumors of the head and neck, 12 genitourinary malignancies, three carcinomas of the breast, and two malignant melanomas. The chest films were analyzed to determine the distribution of lymph node groups involved. Unilateral lymph node enlargement occurred in eight. The most frequently detected lymph node group was the right paratracheal chain (60%), while the subcarinal and posterior mediastinal groups were rarely affected. Of the 25 cases, 10 had radiographic evidence of hematogenous or lymphangitic metastases in addition in the lungs. Metastatic disease from extrathoracic neoplasms should always be considered in the differential diagnosis of hilar and mediastinal adenopathy.

Adolescent↗
PubMed1979

Mammary hamartoma, a benign breast lesion.

Hamartoma or mastoma is a benign breast lesion which is unfamiliar to most clinicians. Five cases with this lesion are presented. It is a rather soft, sharply delineated lump which may cause a considerably asymmetry of the breasts. Radiologically it appears as a circumscribed tumour with homogenous or varying density and at operation the lump is easily enucleated. Histologically it contains normal or dysplastic mammary tissue. It is unilateral and benign. The lesion is now more frequently diagnosed because of increased use of mammography and can be mistaken for a neoplasm. It is therefore important that clinicians and radiologists are acquainted with it.

Adult↗
PubMed1978

[Subcutaneous mastectomy (author's transl)].

Problems of indication (premalignant disease, difficult check-up, carcinophobia), of resection (incomplete, unilateral, compromises) and of breast reconstruction (one- or two stage procedure, capsular fibrosis, difficult follow-up) are discussed.

Breast Neoplasms↗
PubMed1976

[Paget's disease of the breast in a male].

The case of a 78-year-old man with Paget's disease of the breast, described herein, appears to be only the 22nd histologically proven case of this rare condition; in over 100 years less than 50 cases have been reported. Since this patient had no underlying tumour or nodal involvement the operation consisted of total mastectomy with removal of axillary nodes only, rather than the classical radical mastectomy. All eczematoid lesions of the areola of the breast that persist for more than 2 weeks or are unilateral should be considered Paget's disease until proven otherwise by biopsy.

Aged↗
PubMed1976

Experience with opposite breast biopsy in patients with operable breast cancer.

One hundred and nine patients with unilateral breast carcinoma and no palpable abnormality of the contralateral breast were evaluated by opposite breast biopsy. Our patient population yielded four noninfiltrating carcinomas, and one infiltrating carcinoma for an incidence of 4.5%. The one infiltrating cancer was suspected on a preoperative mammogram. We have discontinued the routine use of the opposite breast biopsy as a diagnostic tool in patients with unilateral breast cancer, in patients with no palpable abnormality and a normal mammogram.

Adult↗
PubMed1992

[Primary breast lymphoma. A case report].

The authors report a case of a primary breast lymphoma (P.B.L.). A 23 year old female patient presented with a primary lymphoma of the left breast, pleural effusion and a biological syndrome of spontaneous tumor lysis. She had salvage mastectomy then chemotherapy. The issue was rapidly fatal, the day after the induction of chemotherapy. P.B.L. are uncommon. Less than 300 cases are found in the literature. These lymphomas are classified in 2 types: The first, the Burkitt type lymphoma, usually bilateral, rapidly fatal, and affects pregnant or lactating women. The second, unilateral, afflict patients at any age.

Adult↗
PubMed1975

[Histological diagnosis and therapy of rare breast neoplasms].

Occasional rare benign and malignant breast tumours present diagnostical difficulties, how a report on 8 rare forms of tumours among 564 breast rumors (351 benign, 213 malignant) of the years 1965--1972 at the Universitäts-Frauenklinik Greifswald shows. We found among 351 benign breast tumours 2 rare forms: 1 tubular adenoma and 1 nodular lymphoreticulosis. We diagnosed among 213 malignant breast tumours 6 rare tumour-types: one at a case an unilateral respectively a bilateral noninvasive lobular carcinoma from the carcinoma-in-situ-type, 1 spindlecell- and 2 reticulosarcoma, which in one case the starting-point of the heterogeneous differentiated reticulosarcoma was obvious situated in a teratoid tumour. Last case dealt with a real cystosarcoma phylloides, of which oncological and terminological problems were additional discussed.

Adenoma↗
PubMed1975

[The bilateral breast neoplasm].

Of 282 patients, who had been treated for breast cancer between 1968 and 1973, bilateral carcinoma was diagnosed in 23 women. In these, a simultaneous second carcinoma was found seven times; in 16 cases, the second carcinoma developed during the further course of the disease, wherein the free intervals amounted to maximally 20 years. Attention is drawn to the relatively high risk of up to eight or ten per cent for the development of a carcinoma in the contralateral breast following the previous unilateral carcinoma. This reason calls for a half-yearly, clinical and radiological check-up examination of women having been treated for carcinoma of the breast. Finally, the problem of differentiation of a primary, autonomous second carcinoma from metastases of the first carcinoma on the contralateral side is considered and discussed with regard to the corresponding references in literature.

Adult↗
PubMed1977

A comparative study of some pathologic features of mammary carcinoma in Tokyo, Japan and New York, USA.

Epidemiologic and clinical studies conducted in the past 15 years have demonstrated striking differences in the biology of mammary carcinoma among Japanese and American women living in their native countries. These variations have, in part, been related to some differences in the characteristics of the primary tumors between the two groups. As part of a collaborative study we have had an opportunity to compare the stage of disease and to examine and compare histological sections of patients with breast carcinoma treated in 1973-74 at the National Cancer Center Hospital (NCH) in Tokyo and in 1974 at the Memorial Hospital (MH) in New York. The former group consisted of 216 and the latter of 555 carcinomas. Fewer patients in each group had axillary metastases than reported in a prior study of patients treated at MSKCC and in Tokyo 20 to 30 years earlier. Negative axillary nodes were now found in 58% of the MH patients and in 63% of women treated at the NCH. The magnitude of improvement in stage relative to the prior report was similar in both groups. However, it would appear that the change occurred mainly from the mid-1950s to the 1960s in New York and approximately 10 years later in Tokyo. Results of this study confirming prior reports were: (1) higher frequency of colloid and of medullary carcinoma with lymphoid stroma and lesser frequency of lobular carcinoma in the Japanese patients; (2) more intense lymphoid infiltrate in and around primary tumors in Japanese women; (3) higher frequency of rounded or circumscribed tumors in Japanese women; and (4) the more frequent occurrence of intralymphatic tumor emboli within the breast in American women. The difference in the frequency of lobular carcinoma was less striking when comparison was limited to patients with unilateral carcinoma.

Adenocarcinoma, Mucinous↗
PubMed1977

Unilateral breast-feeding and breast cancer.

Women of fishing villages in Hong Kong by custom breast-feed with only the right breast. The hypothesis that the unsuckled breast may have an altered risk of cancer development was investigated. Records of the radiotherapy divisions in Hong Kong between 1958 and 1975 were searched, and breast-cancer patients were interviewed for a detailed history of lactation. The overall left/right ratio of cancer in the breasts of 2372 women with unilateral breast carcinoma was 0-97, indicating that breast cancer was equally distributed between the two sides. Of 73 patients with a history of exclusively one-sided breast-feeding, 27 of 34 patients aged 55 or over (79-4%) and 19 of 39 patients under age 55 (48-7%) had a carcinoma in the unsuckled breast. Comparisons of patients who had nursed unilaterally with nulliparous patients and with patients who had borne children but had not breast-fed indicated a highly significant increased risk of cancer in the unsuckled breast. No statistically significant differences in laterality of breast cancer were found in 52 patients who had for convenience nursed to a greater extent from one side than the other. This study indicates that in post-menopausal women who have breast-fed unilaterally, the risk of cancer is significantly higher in the unsuckled breast and that breast-feeding may help to protect the suckled breast against cancer.

Adult↗
PubMed1978

Management of familial breast cancer. I. Biostatistical-genetic aspects and their limitations as derived from a familial breast cancer resource.

Practical guidelines are given to promote decision-making logic by the physician in managing patients seeking consultation (consultands) because they may be at high familial risk for breast cancer and associated malignant neoplasms. The protocol is designed to aid in the assessment of patients who may become candidates for intensified cancer surveillance and/or prophylactic surgery. A resource comprised of 90 extended breast cancer-prone pedigrees provides the basis for these specific recommendations. The resource shows marked tumor heterogeneity among pedigrees, an approximate 50% incidence of breast cancer and associated malignancies among offspring of affected parents, and threefold higher risk for development of mammary carcinoma in the opposite breast of familial patients with unilateral disease than in sporadic patients. In utilizing this protocol, it is crucial that family history be highly accurate from the standpoint of genealogic relationships and pathologic tumor verification so that management recommendations may reflect sound risk factor assessment. Interpretation of familial risk factors should ideally be made by an informed medical-geneticist. All members of the medical team should then be appraised of familial risk and collectively engage in decision making with the consultand. We believe that this approach can foster more effective control of familial breast cancer.

Adolescent↗