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Results for “Unithiol”

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At least 19 recordsLinked to original sources
PubMed1979

99mtc-unithiol complex, a new radiopharmaceutical for kidney scintigraphy III. Studies of labelling unithiol with 99mtc.

Labelling of 2, 3-dimercaptopropane sodiumsulphonate (Unithiol) with 99mTc resulted in essentially three components in the GCS pofile: the top zone, a low-molecular Complex A and a high-molecular Complex B. In the presence of tin metal a fourth component, Complex C, could be distinguished. Complex A was relatively independent of pH, the proportion of Complex B increased with increasing pH. Methods were developed for preparing, with over 80% labelling efficiency, either Complex A or Complex B, each having high stability in the preparation vials and in human blood.

Chlorides↗
PubMed1986

[Effect of unithiol and thymidine on the toxic and therapeutic action of adriamycin].

The influence of unithiol and thymidine treatment on the acute toxicity and therapeutic effect of adriamycin in hemoblastosis La was studied in CBA and C57B1 mice. Unithiol and thymidine were shown to markedly decrease the toxicity of different doses of adriamycin which resulted in a lower mortality and longer survival of the animals. When unithiol and thymidine were administered in combination, their antitoxic effect was added. Since unithiol and thymidine administration does not diminish the therapeutic effect of various doses of adriamycin, unithiol may be recommended for clinical use to decrease adriamycin toxicity in cancer patients.

Animals↗
PubMed1976

99mTechnetium-unithiol complex, a new pharmaceutical for kidney scintigraphy.

The investigations were carried out with a newly synthesised, original 99mTc-Unithiol complex (Unithiol-2,3-dimercaptopropansulphonate). It accumulates in the kidneys and enables their scintigraphic examination at 90--180 minutes after the administration. The study was performed on rats, rabbits and dogs. 99mTc-Unithiol complex accumulation in rat kidneys was 34,9%, 44,5% and 67,8% of dose after 1, 2 and 3 h respectively. Good reability of the scintigraphic picture of the kidneys in rabbits and dogs confirms the accumulative capability of the complex in these organs. It was found by means of ascending paper chromatography that the purity of the 99mTc-Unithiol complex exceeded 90%.

Animals↗
PubMed1990

[Neutralization of toxic action of endotoxins of gram-negative bacteria by unithiol and magnesium sulphate].

The experiments were carried out on mice of CBA strain. The animals received lysate of S. typhimurium in the dose of LD50. The injection of lysate was followed by an increase in the level of malonic dialdehyde (MDA) suggesting the lipid peroxidation (LPO) activation in the liver. At the same time the concentration of cyclic adenosine monophosphate (cAMP) in the liver and the lungs was decreasing, which was indicative of the decrease in the activity of prostaglandins. The injections of unithiol prevented both the activation of LPO and the decrease in the concentration of cAMP, that effect having been caused by the antioxidant action of unithiol. The repeated injection of unithiol protected the animals from death in intoxication by lysate of S. typhimurium and Shigella sonnei; the protection manifested itself in the 4.2 and 3.7-fold increase in LD50 respectively. Magnesium sulphate enhanced the protective action of unithiol.

Animals↗
PubMedDate not supplied

[Decrease of toxic effects of aminothiol radiation-protective agents and increase of chemical protection action against ionizing radiation by the use of unithiol].

It has been shown that unithiol diminishes toxic action of cysteamine, AET, and disulfide of WR-1065 on mice. This permits to enhance protection of animals against X-rays by increasing of protector doses. The effect of unithiol on cysteamine action in rats was the same. Antitoxic effect of unithiol on cysteamine was shown both at i.p. and p.o. protector administration. The effect was also revealed in Chinese hamster V-79 cell culture. Combined disulfide of cysteamine and unithiol was synthetized, which ensures effective prolonged protection against ionizing radiation.

Animals↗
PubMed1978

The influence of unithiol and spironolactone on the biliary excretion of 203Hg in rat.

Rats with cannulated bile ducts were intravenously given 203HgCl2 in the dose of 120 microgram of Hg2+ per rat. Intramuscular administration of Unithiol (sodium 2,3-dimercaptopropanosulphonate) 4 and 7 h after 203Hg injection markedly increased both biliary and urinary excretion of 203Hg. In rats with Spironolactone (17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid, gamma-lactone, acetate) pretreatment the effect of Unithiol on the biliary excretion of 203Hg was enhanced. Urinary excretion of mercury was lowest in comparison with Unithiol treated group.

Animals↗
PubMedDate not supplied

[Effect of unithiol on the ultrastructure of the myocardium and adrenals in endotoxin shock].

Administration of unithiol to animals with endotoxin shock promotes deposition of catecholamines in chromaffin cells of the adrenals, blocks their secretion to the bloodstream and prevents the development of injuries to the cortical substance of the gland. Administration of unithiol for endotoxemia prevents damage to intracellular organelles of cardiomyocytes. However, insignificant disorders of the contractile apparatus of the cells and histohematic barriers are maintained. The capacity of unithiol to prevent the progress of destructive alterations in the heart and adrenals permits recommending it for use in combined treatment of septic conditions.

Adrenal Glands↗
PubMedDate not supplied

[The effect of unithiol on the antineoplastic and antimetastatic activity of N-methylformamide].

Antitumor and antimetastatic properties of N-methyl formamide--an agent related to differentiation of tumoral cells and unithiol, official detoxicating drug containing SH-groups were studied in C57Bl/6 mice inoculated with Lewis's lung carcinoma. The drugs were administered intraperitoneally into animals at days 1, 4, 7, 13 and 16 after carcinoma inoculation and their effects were evaluated at day 19. Single administration of unithiol, 5 mg/kg body weight, did not affect tumor growth and metastases spreading. At the same time, N-methyl formamide (single administration of 300 mg/kg body weight) inhibited tumor growth and decreased 5-fold an amount of spontaneous metastases in lungs. However, the antitumor and antimetastatic activities of N-methyl formamide were decreased after simultaneous administration with unithiol. Importance of SH-groups in therapeutic effects of N-methyl formamide is discussed.

Animals↗
PubMedDate not supplied

[Experimental study of the anti-arrhythmia action of unithiol].

Tests conducted on 70 rabbits showed that cardiac rhythm disorders produced by introduction of a 10% calcium chloride solution was prevented by the administration of unithiol. With developing arrhythmia in the muscle of the rabbits' heart the level of sulfhydryl groups went down. The introduction of unithiol was followed by a rising content of sulfhydryl groups, especially in the myocardium of the left ventricle.

Animals↗
PubMedDate not supplied

[Experimental study of the antihypertensive activity of unithiol, D-penicillamine and cysteine].

The thiol compounds, unithiol, D-penicillamine and cysteine administered per os, produce an antihypertensive effect in spontaneously hypertensive rats and in animals with experimental renovascular and DOCA-induced hypertension. The drugs reduce the pressor effect of angiotensin I and potentiate and prolong the depressor action of bradykinin in anesthetized normotensive rats. As for the activity unithiol and D-penicillamine are found to be superior to cysteine. This is in a good agreement with the drug inhibitory action in respect to dipeptidyl carboxypeptidase, an enzyme that plays the key role in the control of the activity of the renin-angiotensin and kallikrein-kinin systems of the body.

Animals↗
PubMed1987

[Effect of unithiol and acetylcysteine on lipid peroxidation and the erythrocyte antioxidant system in sensitized guinea pigs].

The effect of unithiol and acetylcysteine on lipid peroxidation, thioldisulfide equilibrium, glucose-6-phosphate dehydrogenase, glutathione reductase and lactate dehydrogenase activity and on erythrocyte resistance was studied in guinea-pigs during sensitization with C. maltosa. Sensibilized animals receiving thiol antioxidants showed partial restoration of normal biochemical levels.

Acetylcysteine↗
PubMed1984

[Unithiol in the treatment of secondary amyloidosis patients].

Seventy-five patients with secondary amyloidosis were treated with unithiol. Good objective results were obtained in 19 patients, who demonstrated considerable improvement of the general well-being, reduction in proteinuria, edemas, appreciable elevation of the levels of total protein. albumins and sulfhydryl groups in blood serum. Satisfactory results were obtained in 18 patients who showed a certain improvement of the general well-being, moderate drop of proteinuria, elevation of the levels of albumins and sulfhydryl groups in blood serum. Twenty-four patients noted only subjective improvement. Fourteen patients did not respond or showed deterioration of the health status. Three patients developed allergic rash which disappeared after drug discontinuation and administration of the common desensitization agents.

Amyloidosis↗
PubMed1980

99mTc-unithiol complex, a new radiopharmaceutical for kidney scintigraphy. IV. Autoradiographic localisation of its cellular distribution in the kidney.

The distribution of 99mTc-Unithiol complex was studied by macro-autoradiography in rats and in rabbit kidneys, and the presence of activity in the renal cortex was easily demonstrated. Using micro-autoradiography, the accumulation of activity in various parts of the nephron was observed to concentrate in the cells of the proximal and distal tubuli to a larger extent than in the glomeruli.

Animals↗