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At least 19 recordsLinked to original sources
PubMed1990

[Prevalence of secondary complications in patients with type I diabetes mellitus. Results of a retrospective analysis of 549 type I diabetic patients of the Ulm University clinic].

In a retrospective study, we analyzed the prevalence of diabetes-associated late complications in 549 type 1 (insulin-dependent) diabetic patients who have been treated at the University Hospital of Ulm between 1980 and 1987. Retinopathy, proteinuria and neuropathy depended on the duration of the disease, whereas age was the major determinant of large vessel disease. After 20 years of diabetes, 85% of the patients showed retinopathy, half of them proliferative retinopathy, 52% had persistent proteinuria (greater than 500 mg/day), 20% of them were under dialysis. 74% of the patients showed signs of peripheral and/or autonomic neuropathy, 19% had manifestations of large vessel disease. There was no consistent correlation between the levels of glycosylated hemoglobin and the occurrence of diabetic late complications. However, hypertension was closely associated with both small and large vessel disease.

Adult↗
PubMedDate not supplied

[Perinatal aspects of 520 twin deliveries between 1965-87 at the Ulm University Gynecologic Clinic].

1. Birth induction in twin pregnancies was substantially reduced to 6% in last few years (1984-87) as opposed to 21% between 1975 and 1980. 2. Premature rupture of the membrane increased in the last years. At a rate of 33% is occurred nearly twice as often as with singletons (18%). A waiting policy increasingly adopted in such cases resulted in 21% of the twin group and 9% of the singleton group being born as late as 48 hours and beyond after membrane rupture. 3. The frequency of Caesarean sections performed in twin pregnancies rose dramatically over the last 22 years: 16%, 36%, 43%, 45%. With singletons, the tendency is reverse: 6%, 22%, 15%, 9%. One of the reasons why Caesarean sections are so markedly on the increase is that the frequency of immaturity in twins is steadily rising. In the past two decades the percentage of second twins less than 2500 grams birth weight rose from 35% to 71%. 4. Labour duration exceeding 12 hours increased from 8% to 21%. The same applies to the expulsion time of the first twin which rose on average from 10 to 21 minutes. 5. Manual delivery of the placenta remained at a steady rate of 25%, compared to 10% after singleton deliveries. 6. Hospitalization time exceeding two weeks decreased in the study period from 33% to 5%. 7. The perinatal mortality rate of twins could be halved in the period from 1965 to 1987, to less than 4%. The frequency of Caesarean sections, on the other hand, increased threefold to 48% now.(ABSTRACT TRUNCATED AT 250 WORDS)

Cesarean Section↗
PubMed1989

[Therapeutic concept of the University of Ulm for the treatment of neuralgiform facial pain].

The therapy of chronic facial pain poses an interdisciplinary problem. Since 1984 the therapeutical plan of Ulm University was developed in such a way that the intensity of pain and the location as well as former treatments are accommodated. The therapeutical steps don't interfere among one another. In the first four years 204 patients were treated with this scheme. A freedom or at least a reduction of pain was achieved in 187 patients.

Autonomic Nerve Block↗
PubMed2002

[Interdisciplinary longitudinal curriculum "Medical psychology, psychotherapy and psychosomatics" (MPPP) at the University of Ulm].

We report the clinical part of the longitudinal curriculum MPPP which was developed by the departments of Medical Psychology, Psychotherapy and Psychosomatic Medicine at the University of Ulm. The commitment and creativity of the participating students in their two undergraduate years inspired us to offer them an interest-guided curriculum for their six clinical semesters. Our paper reports the extensive results of two evaluations that we conducted during the clinical part of this new teaching-model. It became evident that we were successful in transferring continuous, intense and patient-centred psychosomatic and psychosocial contents. Yet the transfer of basic and methodological knowledge was not realised to the extent the students would have appreciated. The positive results of our project encouraged us to expand the concept of an interest-guided curriculum onto the whole academic education in psychotherapy and psychosomatic medicine at our university.

Curriculum↗
PubMed2001

Single-Compound Libraries of Organic Materials: From the Combinatorial Synthesis of Conjugated Oligomers to Structure-Property Relationships This work was made possible with funds donated from Fonds der Chemischen Industrie, the BMBF (Kekulé grant to C.A.B) and the DFG (Schu 929/5-1). We thank Prof. V. Austel, the University of Ulm, for valuable discussions and also Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield (USA), for apparatus support.

Explore the source record for details and available documents.

Journal Article↗
PubMed1995

Blood stem cell transplantation: from preclinical to clinical models.

This introductory statement to the International Symposium "Ten Years of Blood Stem Cell Transplantation in Heidelberg" provides the opportunity to review the experimental work that was necessary to set the stage for the first successful clinical studies to use blood-derived stem cells to treat hemopoietic and other malignancies. The Ulm University research group used the preclinical canine model to systematically and extensively explore the possibilities and limitations of the therapeutic use of blood-derived hemopoietic stem and progenitor cells. It became clear that blood stem cells are physiological elements of the circulating blood, that their concentration can be drastically increased by chemical and biological means, that they do not lose their function during appropriate cryopreservation, and that they can be "purified" and used successfully to restore hemopoiesis after myeloablative conditioning both in the autologous and allogeneic situation. If compared to fetal liver-derived stem cells, there is excellent experimental evidence that fetal liver-derived stem cells may have even more potential in their ability to restore hemopoiesis, and it is evident that much more experimental work is needed.

Animals↗
PubMed1996

[Recurrence and survival rate after surgical therapy of rectal carcinoma].

Between 1983 and 1993, 680 patients with rectal carcinoma were treated at Ulm University. The resection rate was 84%. After undergoing radical surgery, 492 of the patients were followed up regularly at our hospital for a median of 66.9 months (range 4-177.6). Recurrences occurred in 172 patients (35%) and were diagnosed a median of 13 months (range 4-106 months) postoperatively; 9.4% had regional recurrences, 10.4% regional recurrences and distant metastases and 10.2% distant metastases. The 10-year survival rate of the patients in tumour stages I, II and III was 88%, 62%, and 32%. In patients with carcinoma of the midrectum, after anterior resection or abdominoperineal amputation the same local recurrence rate was found.

Follow-Up Studies↗
PubMed2000

Primary staging of lymphomas: cost-effectiveness of FDG-PET versus computed tomography.

The objective of this study was to measure the incremental cost-effectiveness of 2-(fluorine-18) fluorodeoxyglucose positron emission tomography (FDG-PET) versus computed tomography (CT) as diagnostic procedures in the primary staging of malignant lymphomas. The study was based on 22 patients of a clinical study who underwent the diagnostic procedures at Ulm University Hospital between April 1997 and May 1998. Direct costs of FDG-PET and CT, including staff, materials, investment, maintenance and overheads, were valued using a micro-costing approach. The effectiveness of both diagnostic procedures was measured as the percentage of correctly staged patients, given a gold standard for staging. The incremental cost-effectiveness ratio was the main outcome measure. Costs per patient of FDG-PET were 257 euros for FDG production and 704 euros for the FGD-PET scan, thus totalling 961 euros (in 1999 prices). The cost per patient of CT scans was found to be 391 euros. Verified PET findings induced an upstaging in four patients such that the effectiveness was 81.8% (18/22) for CT and 100% (22/22) for PET. Incremental cost-effectiveness ratios (interpreted as the additional costs of a more effective diagnostic strategy per additional unit of effectiveness, i.e. additionally correctly staged patient, achieved) were 478 euros per correctly staged patient for CT versus "no diagnostics" and 3133 euros for FDG-PET versus CT. Great potential for cost saving was identified in sensitivity analyses for FDG-PET. It is concluded that diagnostic accuracy and the costs of the diagnostic procedures could be measured precisely. FDG-PET was more accurate than CT. Decision-makers who consider savings in treatment costs significant may find the cost-effectiveness ratio of PET to lie within an acceptable range. However, more research is needed to assess the long-term treatment and cost effects of more accurate staging. There is significant potential to improve the technical efficiency of PET.

Adolescent↗