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At least 19 recordsLinked to original sources

The effects of nicotine, hexamethonium and ethanol on the secretion of the antidiuretic and oxytocic hormones of the rat.

The actions of nicotine, hexamethonium, and ethanol on the hypothalamo-hypophysial system have been investigated in the rat. The antidiuretic action of nicotine was not inhibited by ethanol, nor by doses of hexamethonium which were sufficient to block both its pressor and convulsant actions. Hexamethonium itself had an antidiuretic action the mechanism of which has been investigated. Nicotine caused a release of oxytocin into the blood which was not blocked by ethanol nor significantly reduced by hexamethonium. The results suggest that any synapse which exists at the supraoptic nuclei is dissimilar in its pharmacological properties to synapses at autonomic ganglia.

Animals↗

Seasonal variations in the response of rats to the antidiuretic hormone.

The antidiuretic response of unanaesthetized rats to intravenous doses of vasopressin has been compared in the different seasons of the year. Significant seasonal differences in sensitivity to the hormone were found; thus the rats responded to smaller doses in spring and summer. Discrimination between doses appeared to be best in summer. Relative variability in response seemed to be least in winter. There appeared from season to season to be a concomitant variation in the same or opposite direction between sensitivity in terms of the average minimum effective dose and environmental factors such as temperature, barometric pressure and relative humidity.

Animals↗