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PubMed1976

Vulvar disease.

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Adolescent↗
PubMed1979

Further observations on the effect of topical progesterone on vulvar disease.

Follow-up studies have confirmed the beneficial effect of topical progesterone in the treatment of vulvar dystrophy, whether of the atrophic, hypertrophic or mixed variety, in both postmenopausal and premenarchal women. If pruritus is a major symptom, topical corticosteroids should be alternated with the progesterone preparation in order to obtain maximum results. Topical progesterone was also found to be useful in the treatment of labial agglutination in children.

Administration, Topical↗
PubMed1975

Invasive vulvar Paget's disease.

Seven cases of invasive vulvar Paget's disease are presented. These are compared with 10 cases of intraepithelial vulvar Paget's disease. On the basis of both clinical and histopathologic observations, the concept of intraepithelial vulvar Paget's disease is supported, and this entity is distinguished from the invasive form. Therapy for the latter is discussed.

Aged↗
PubMed2026

2026 International Society for the Study of Vulvovaginal Disease terminology for vulvar intraepithelial neoplasia and squamous intraepithelial lesions.

The 2026 International Society for the Study of Vulvovaginal Disease terminology for vulvar intraepithelial neoplasia and squamous intraepithelial lesion requires p16 and p53 immunohistochemistry for classification into human papillomavirus-associated or human papillomavirus-independent disease. p16 and p53 are tumor suppressor proteins; block positive p16 staining is a surrogate marker for genomic integration of oncogenic human papillomavirus, while null or overexpressed p53 staining correlates with TP53 mutation. Human papillomavirus-associated and human papillomavirus-independent vulvar intraepithelial neoplasia represent 2 distinct entities with different diagnostic considerations, treatments, surveillance strategies, and prognoses. The designation of 'neoplasia' vs 'lesion' reflects biological behavior, with neoplasia signifying an established risk of progression to cancer. Human papillomavirus-associated disease maintains a 2-tier nomenclature: human papillomavirus-associated vulvar intraepithelial neoplasia for precursors to vulvar squamous cell carcinoma vs low-grade squamous intraepithelial lesion and condyloma for transient human papillomavirus manifestations. While human papillomavirus-associated vulvar intraepithelial neoplasia is preferred, high-grade squamous intraepithelial lesion is retained as acceptable in some settings to maintain consistency with nomenclature for analogous lesions across the lower genital tract. Human papillomavirus-independent disease almost always arises from longstanding lichen sclerosus. The updated terminology for human papillomavirus-independent precursors to squamous cell carcinoma is human papillomavirus-independent vulvar intraepithelial neoplasia, subcategorized as p53 mutant or p53 wild type. Verrucous vulvar intraepithelial neoplasia is a subtype of p53 wild type human papillomavirus-independent vulvar intraepithelial neoplasia and the usual precursor to verrucous carcinoma. Vulvar aberrant maturation encompasses human papillomavirus-independent lesions of uncertain neoplastic potential arising in lichen sclerosus that raise concern for but are not diagnostic of human papillomavirus-independent vulvar intraepithelial neoplasia. Collaboration between clinicians and pathologists is essential to achieve accurate diagnosis, optimal individualized treatment, and consistent application of this terminology in practice and research.

Humans↗
PubMed1978

Treatment of genital herpes simplex virus infection with photodynamic inactivation.

A double-blind randomized study to evaluate the effect of proflavine in the treatment of genital herpesvirus infection was conducted. One hundred fifty-seven women were studied, of whom 75 were treated with proflavine (treated women) and 82 were treated with placebo (control group). There were 62 women with primary disease and 95 with recurrent infection. Under the conditions by which this study was conducted, there was no apparent difference in the time of healing of lesions, development of recurrences, or virus isolation following treatment in the proflavine-treated and control groups.

Acridines↗
PubMed1978

Cysts of the female external genitalia in the newborn infant.

Nineteen cases of cysts of the external female genitalia were diagnosed over a two-year period, giving an incidence of six per 1,000 female infants. The embryology, morphology, and differential diagnosis are discussed. No treatment was given and follow-up at two months of age revealed complete resolution of the cysts, thereby establishing their benign course in the newborn period.

Clitoris↗