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Cardiac responses of dogs to nonsynchronous and heart synchronous whole-body vibration.

Changes in cardiac function produced by synchronizing vibration-induced forces with events in the cardiac cycle were compared to those for the nonsynchronous case in eight chronically instrumented, tranquilized dogs. The supine animals received sinusoidal, whole-body vibration (along the spinal +/- Gz axis) at a constant acceleration amplitude (+/- 0.75 G). The vibration frequency (2-3 Hz) was set equal to the paced heart frequency. Synchronization between vibration and cardiac cycles on a beat-by-beat basis produced a specific and sustained cardiovascular response; such a sustained response was not possible with nonsynchronous vibration. With synchronization, relationships could be found and sustained in which changes either exceeded or were below mean nonsynchronous levels, in some cases below previbration values. For the synchronous vs. nonsynchronous states, significant modification of cardiac function was reflected in parameters such as coronary flow (+15% to -34%) and myocardial oxygen consumption (+21% to -51%). Thus, whole-body oscillation acceleration (vibration) is a forcing function that can produce and maintain a particular cardiovascular response.

Animals

Effect of whole-body vibration in combined axes and with noise on subjective evaluation of ride quality.

The effects on ratings of ride quality of discomfort produced by complex vibration and noise stimuli were investigated. The initial study examined effects of simultaneous vibration in the vertical and lateral axes in a simulated passenger aircraft. The second study examined the effects of simultaneously presented vertical vibration and noise stimuli. In both studies the components of complex stimuli were found to combine their effects at low levels of stimulation but to act separately at higher levels.

Adolescent

Comparison of the subjective intensity of sinusoidal, multifrequency, and random whole-body vibration.

An intensity matching technique was used in two experiments to test the independent component method for evaluating complex vibration environments, recommended by current vibration standards; In the first experiment, seated subjects adjusted the intensity of a 25 Hz sinusoid to match the subjective intensity of 11, 17, 40, and 63 Hz simusoids, presented either singly or in combinations of two, three, or four frequencies. In the second experiment, 25 Hz was again used to match the subjective intensity of third octave bands of random vibration with center frequencies of 16, 20, 25, 31;5, and 40 Hz, presented either singly or in combinations of two, three, or four bands. The results showed that the acceleration of the matching response increased significantly as the number of sinusoids or third-octave bands in the stimulus increased; These findings indicate that the independent component evaluation method will underestimate the severity of complex vibration environments, and suggest that their perceived intensities may be more accurately reflected by the weighting technique included in the standards as an alternative evaluation method.

Acceleration

Influence of whole-body mechanical vibration on altitude convulsion threshold.

Altitude convulsion threshold was used for determining the maximal hypoxic tolerance of the mouse during whole-body transverse vibration. Elevation of the lung weight-body weight ratio was taken as evidence of lung edema. It was observed that vibration of 8 cps at 2 mm displacement (peak to peak) or 4 cps at 4 mm displacement did not affect the altitude convulsion threshold and the said ratio. On the other hand, vibration of 12 cps at 2 mm displacement, or 8 and 12 cps at 4 mm displacement caused an increase in a altitude convulsion threshold as well as lung edema. The possible mechanism of these changes is discussed.

Adaptation, Physiological

Occupationally relevant vibrations and the brain: frequency-dependent proteomics signatures in a rat model.

INTRODUCTION: Occupational exposure to whole-body vibration (WBV), particularly in agricultural environments, has been associated with adverse cognitive and physiological effects. This study examined the neurophysiological impact of WBV in a rat model at 4 Hz and 30 Hz, frequencies representative of off-road and on-road vehicle operation. METHODOLOGY: Forty-four Sprague-Dawley rats were assigned to control (0 Hz), low-frequency (4 Hz), or high-frequency (30 Hz) vibration conditions. After three days of exposure, brain tissues were collected and analyzed using mass spectrometry-based proteomics to identify differentially expressed proteins. RESULTS: Proteomic profiling revealed distinct, frequency-dependent alterations in brain protein expression. Compared with controls, 32 cognition-related proteins were differentially regulated at 4 Hz and 29 at 30 Hz, with 13 differing between the two vibration conditions. Principal component analysis showed clear separation among groups, indicating unique proteomic signatures for each exposure frequency. Functional enrichment and protein-protein interaction analyses demonstrated involvement of synaptic plasticity, cytoskeletal organization, calcium regulation, and neurotransmitter release. Exposure to 4 Hz was associated with the upregulation of proteins involved in calcium homeostasis and synaptic integrity, suggesting potential disruption of cognitive processes. In contrast, 30 Hz increased the expression of proteins related to axonal guidance and neuroprotection, indicating a less clearly adverse response that may reflect adaptive or potentially beneficial effects. DISCUSSION: These findings provide new insight into biological mechanisms underlying WBV-induced cognitive changes and underscore the importance of vibration frequency in shaping neurophysiological outcomes. They also establish a foundation for future studies integrating proteomics with behavioural assessments in animals and humans.

Animals

Parameters for assessing vibration-induced cardiovascular responses in awake dogs.

The vibration parameters for assessing the response of the cardiovascular system to whole-body vibration were studied. Six awake, chronically instrumented canines were restrained with their spines vertical, and exposed to GZ sinusoidal vibration of 2-12 HZ for a constant peak acceleration amplitude of +-1.0 G. Vibration exposures of 30 s with intervening recovery periods of 2 min were employed. The following variables were measured: mean heart rate (MHR), stroke volume (SV), mean aortic flow (MAF), mean aortic pressure (MAP), the peak net force transmitted to the canine/body weight (PNF/BW), and the vibration platform frequency (ft), displacement, and acceleration. The percentage change from control (no vibration) of MAF varied linearly with PNF/BW for all cases. MAF also varied linearly with the log MHR/ft for the number of dogs which primarily changed MHR during the vibration exposures. The response of MAP was minimal in all cases, indicating a decrease in total peripheral resistance with increasing PHF.

Animals

[Spectrum analysis of stabilograms with special reference to changes following whole body vibration].

The location of the body's gravicenter in the horizontal plane was measured by means of a force platform. The 4 male subjects stood upright with eyes closed. Power-density spectra of the frontal and sagittal stabilograms were estimated. Repeated investigations made it possible to assess intraindividual variability and to evaluate significant interindividual differences. The power spectral density was not altered by a controlled sitting posture observed for 30 min. Low-frequency whole-body vibration with an exposure time of 30 min and a permissible level according to the "fatigue decreased proficiency boundary" (International Standard ISO 2631) induced a significant increase of the power spectral density below 0.25 Hz and a decrease above this frequency. The results indicate that the power density spectral analysis of stabilograms is a suitable method for evaluating a biological effect of vibration.

Humans