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At least 19 recordsLinked to original sources
PubMed1995

[Studies on function of vegetative nervous system in cardiopathic patients with heart-qi deficiency syndromes and heart-yin deficiency syndromes].

To explore the changes of the function of vegetative nervous system in the patients with the syndromes of Heart-Qi Deficiency (HQD) and Heart-Yin Deficiency (HYD), 53 cases of heart diseases were divided into HQD and HYD, the duration between heart beats, differences of blood pressure in the lying and standing position, and urine-catecholamine/24 hrs was determined separately, and compared with control group. The results showed that the duration between heart beats and heart rate in the lying position in those patients of HQD didn't manifest significant difference with control group. But in 78.9% of patients, the differences of heart rate in expiration/inspiration, surpassed 15 beats per minute, and the proportion of 30/15 was less than 1.03. Compared with control group, the difference was significant (P < 0.01). Meantime, the differences of heart rate of lying/standing position was less than 15 beats per minute, and the difference of blood pressure had an increasing tend in 47.4% of the cases. Those patients of HYD didn't show any difference in the above indexes. Urine-catecholamine/24 hrs in both of the two groups surpassed that of control group (P < 0.01). In short, this study showed that syndromes of HQD and HYD both displayed disturbed function of the vegetative nervous system, and their types and severities were correlated with the difference of Syndromes.

Adult↗
PubMed1989

[Power spectral analysis of heart rate in qi deficiency and both qi and yin deficiency in patients with coronary heart disease].

Qi deficiency (QD) and both Qi and Yin deficiency (QYD) are most common in TCM classification of CHD patients with insufficiency syndrome. The authors used the power spectrum of spontaneous heart rate fluctuation (PSHF) to analyze the function of cardiac regulation in 30 QD patients and 27 QYD patients with CHD and compare with the control group of 30 cases for discussing the association between different TCM syndrome patterns and the function of cardiac nerve regulation. The main results were as follows: (1) Low-frequency areas of PSHF in QYD (34.15 +/- 11.60%) were significantly higher than those in QD group (26.24 +/- 11.57%) and the control group (27.80 +/- 11.65%). The L/H ratio in QYD (1.78 +/- 0.96) was significantly higher than those in QD (0.91 +/- 0.64) and the control group (0.98 +/- 0.58). The changes of PSHF in QYD could have some relations with the increasing of the activity of sympathetic nervous system. (2) The change in body posture was used as a load test to study cardiovascular regulation in different TCM patterns of insufficiency syndrome with CHD. In control group the L/H ratio increased with the change of body posture from 0.98 +/- 0.58 to 4.29 +/- 0.89 (P less than 0.001), while in QD group and QYD group increased from 0.91 +/- 0.64 to 1.67 +/- 0.83 (P less than 0.05) and 1.78 +/- 0.96 to 1.85 +/- 0.87 (P greater than 0.2) respectively. The results suggested that cardiovascular baroreceptor reflex was decreased in CHD patients, and QYD group was inferior to DQ group.

Aged↗
PubMed1989

[Study on the mechanism of denuded tongue coating due to yin deficiency].

Denuded tongue coating is an important sign of serious Yin deficiency. The total number of exfoliated cells increased in the imprint of a Yin-deficient tongue. Not only the cells of the superficial layer but those of the middle layer appeared. Many necrotic cells could also be seen. This picture showed that the cell exfoliation rate of a Yin-deficient tongue was faster than in a normal tongue, caused chiefly by the degeneration and necrosis of the epithelial cells. It is believed that cell necrosis is the principal feature of the Yin-deficient tongue. This is in accordance with the TCM theory that denuded tongue coating is due to exhaustion of Yin fluid. Study on lingual morphology: The filiform papillae disappeared in slices of Yin-deficient tongue. The fungiform papillae had atrophied, the number of strata of epithelial cells reduced, and there were no complete keratinocytes or granules, tonofilaments and membrane coating granules in the cytoplasm. Observation of the microcirculation of fungiform papillae of a Yin-deficient tongue showed: the structure of vessels was abnormal, blood flowed slowly, red blood cells aggregated and the vessels dilated. Microcirculation of the blood was stagnant. The disturbance of microcirculation could accelerate the abnormal metabolism of lingual epithelial cells and cell necrosis, resulting in denuded tongue coating. Analysis of salivary zinc level: The salivary zinc level (0.232 micrograms/ml) of the patients with Yin-deficient tongue was significantly higher than that of healthy subjects (0.099 micrograms/ml). Zinc can affect the formation and function of nuclear spindle in cellular mitosis. The change of zinc level may be a pathogenic factor in Yin-deficient tongue.

Adult↗
PubMed1993

[Effect of yin and qi tonifying herbs on hyperthyroid model of yin-deficient rats].

The article reports the effect of Yin and Qi tonifying herbs (Radix Rehmanniae, Radix Ophiopogonis and Pseudostellaria Heterophylla) on hyperthyroid model of Yin-deficient rats. The model rats were made Yin-deficient by injecting thyroxine. Observation showed that after injection, indexes such as anus temperature, oxygen consumption, weight, diet, activity, general conditions, triiodothyronine (T3) and thyroxine (T4) in serum were markedly changed. It is thus suggested that the Yin and Qi tonifying mixture of the above three herbs can regulate and correct Yin-deficiency in hyperthyroid model of Yin-deficient rats.

Animals↗
PubMed1989

[Analysis of 35 cases of pathology in yin deficiency syndrome].

Thirty-five cases of the pattern of Yin deficiency were studied including 18 cases of Liver and Kidney Yin deficiency, 2 cases of Lung and Kidney Yin deficiency, 15 cases of heat invasion into Ying and Blood with deficiency both in Qi and Yin. These cases displayed the following characteristics: (1) Course of the disease was insidious, protracted and prone to frequent exacerbations. (2) Clinical manifestations resulted mostly from functional impairment or metabolic derangements in vital organs/tissues, thus manifesting pleomorphism and complexity. Pathologic changes could be seen in almost all organs and tissues, being mostly marked in the liver, adrenals, testes, gastrointestinal tract, lungs and heart. The liver showed chronic active inflammatory changes or subacute necrosis. The adrenal cortex was overtly atrophic, involving all zones. Cell cytoplasm was scant and red stained with loss of lipid vesicles. The testis was also markedly atrophic. There was interstitial edema with scattering of convoluted seminiferous tubules. There was mild hyperplasia of the basement membrane. The germinal cell layer was thin and spermatogenesis decreased. Gastrointestinal mucosa was thin generally and submucosal edema was evident. Infiltrating inflammatory cells were predominantly lymphocytes. (3) These changes could be categorized as blood stasis, chronic inflammation, necrosis and atrophy that signify degeneration with impairment or loss of function. As a whole, Yin deficiency syndrome is merely a nonspecific term that covers a conglomeration of sundry chronic disease state.

Adult↗
PubMed2004

[Exploration on the relationship between pathogenesis for yin-deficiency of acute myocardial infarction and immediate prognosis as well as its mechanism].

OBJECTIVE: To study the relationship between pathogenesis for Yin-deficiency of acute myocardial infarction (AMI) and immediate prognosis as well as its neuro-endocrine mechanism. METHODS: According to the TCM standard of Syndrome Differentiation of Deficiency Syndrome, 194 patients with AMI were classified into the typical Yin-deficiency group (n = 26), the non-typical Yin-deficiency group (n = 61) and the non-Yin-deficiency group (n = 107). Their venous blood samples were collected in the morning while lying on their backs to detect plasma levels of adrenaline, noradrenaline, aldosterone, atrial natriuretic peptide (ANP), corticoid and myocardial enzymes, as well as their hospitalization days and mortality in hospitalized period were calculated and compared in the three groups, with the 30 healthy persons as control. RESULTS: Levels of serum creatine phosphokinase, creatine phosphokinase isozyme, plasma adrenaline, noradrenaline, aldosterone, hospitalization days and mortality were higher in the Yin-deficiency groups than in the non-Yin-deficiency group (P < 0.05, P < 0.01). As compared the indexes between the typical and the non-typical Yin-deficiency groups, significant difference only showed in plasma aldosterone and ANP, which was significantly higher in the former (P < 0.05, P < 0.01). Plasma corticoid level was insignificantly different between the Yin-deficieny groups. CONCLUSION: Patients with AMI of Yin-deficiency type was severer in myocardial damage, with longer hospitalization period and higher mortality, it is probably due to the hyper-activated sympathetic-adrenaline system and strengthened activity of aldosterone in them.

Adult↗
PubMed1990

[Tongue temperature of healthy persons and patients with yin deficiency by using thermal video].

The normal tongue originated from medical workers in our hospital and the Yin deficiency tongue originated from patients who possessed typical phenomena of Yin deficiency including smothery fever, dry mouth and so on. Determination of different area's temperature on tongue surface showed that the immediate temperature on areas of the tip, edge and medium of tongues and the delay temperature on areas of the tip, edge of tongues in patients with Yin deficiency was higher than that in healthy persons and possessed statistical significance. The tongue color in patients with Yin deficiency, the higher the tongue temperature obtained. This suggested that the degree of Yin deficiency relates to the tongue temperature. Lingual diagnosis is an essential component of treatment according to differential diagnosis in TCM. The authors consider that the determination of the tongue temperature by using thermal video will be helpful to raise the accuracy of TCM diagnosis and to appraise the real effect of Chinese herbs on patients with Yin deficiency.

Adult↗
PubMed1989

[Some parameters of blood-stasis, yin deficiency, and yang deficiency in patients with remote myocardial infarction].

This paper demonstrates some investigations on the differentiation of symptom-complex for old myocardial infarction patients (OMI). Among total 100 cases, 20 cases of blood-stasis type, 28 cases of Yin deficiency type and 52 cases of Yang deficiency type. Several laboratory investigations had been carried out for them. The results indicated the level of HDL-C was decreased, LDL-C was increased, ratio of HDL-C/TC was also decreased, platelet aggregation test (PAgT) was increased, factor VIII related antigen (VIII R: Ag) was elevated, among the above 3 types, especially in Yin deficiency group, showed statistically significant. In Yin deficiency group, the ACG tracing demonstrated late bulge type or in a plateau form, A/E-O greater than or equal to 15%. Yang deficiency group, SV, CO, CI were decreased, when compared with Yin deficiency all P value less than 0.01. Among 3 differentiation symptom-complex, microcirculation changes and degree of blood-stasis were in same appearance.

Adult↗
PubMed2003

TCM treatment for 40 cases of rheumatoid arthritis with channel blockage due to yin deficiency.

To verify the therapeutic effects of the method of softening and lubricating the joints, and calming the endogenous wind in case of rheumatoid arthritis (RA) with the syndrome of channel blockage due to yin deficiency, 60 RA patients with the syndrome of channel blockage due to yin deficiency were randomly divided into a treatment group (40 cases) and a control group (20 cases) and treated respectively by the above method for the former and with Zheng Qing Feng Tong Ning Tablets ([symbol: see text]) for the latter. The result turned out to be that the effect in the treatment group was very satisfying. The treatment group obtained a better result in the accumulated points of syndrome and RA, morning rigidity of the joints, grip strength, 20m walking time and erythrocyte sedimentation rate (ESR) (P < 0.01 or P < 0.05). The above indicates that channel blockage due to yin deficiency is an important pathogenesis of RA, and calming the endogenous wind is a method of choice for treating RA.

Adult↗
PubMed2004

[Effects of granules for nourishing kidney and strengthening brain on main symptoms of kidney-yin deficiency and blood stasis syndrome and hemorrheological characteristics of brain atrophy].

OBJECTIVE: To explore the influence of granules for nourishing kidney and strengthening brain (GNKSB) on main symptoms of kidney-yin deficiency and blood stasis syndrome and the hemorrheological characteristics of brain atrophy patients. METHODS: Ninety patients of brain atrophy with kidney-yin deficiency and blood stasis syndrome were randomly divided into two groups. Sixty cases in treatment group were treated with GNKSB, and the 30 cases in control group were treated with piracetam for 8 weeks. RESULTS: The effective rate of treatment group was 73.3%, with significant difference as compared with 46.6% of the control group (P<0.01). The scores of symptom-assessment of the two groups were also significantly different (P<0.01). The mini-mental state examination of treatment group was obviously improved, and was significantly different as compared with the control group (P<0.01). The scores of Hasegawa's dementia scale and activities of daily living were increased, but without significant difference as compared with the control group. The platelet aggregation rate was improved, with significant difference as compared with the control group (P<0.05). The whole blood viscosity was also improved obviously, but without significant difference as compared with the control group. CONCLUSION: GNKSB is effective for kidney-yin deficiency and blood stasis syndrome of brain atrophy patients and can improve their mental state and the hemorrheological indexes.

Aged↗
PubMed1992

[Clinical study of qianxining in the treatment of 60 cases of yang hyperactivity due to yin deficiency type of hypertension].

60 cases with Yang Hyperactivity due to Yin Deficiency type of hypertension were randomly divided into two groups. One was treated with TCM and the other with WM as control. The results showed that: (1) there were no significant differences in the total effective rate and the amplitude of lowering of blood pressure between two groups; (2) the improvement of symptoms and disturbance of autonomic nerve was significant in TCM group in comparison with control; (3) there were some changes in HR, SV, plasma PRA, TXB2 and 6-keto-PGF1 alpha level in both groups, but the decrease of TXB2/6-keto-PGF1 alpha ratio was significant in TCM group only (P < 0.05); (4) TC and TG in patients with hyperlipemia showed a remarkable drop in TCM group (P < 0.02; P < 0.005). All these revealed that Qianxining was a satisfactory hypotensive remedy and a further exploration of its mechanism is suggested.

6-Ketoprostaglandin F1 alpha↗
PubMed1994

[Study on motilin and spleen-yin deficiency].

The Plasma motilin level in 44 cases patients with Spleen-Yin deficiency (SYD) was observed and compared with Spleen-Qi Insufficiency (SQI), the normal control group. SYD patients were treated using self-made Shen Rou Yang Zhen Tang oral liquor. The results showed that plasma motilin level was higher significantly than that of the control group (P < 0.01), but was remarkably lower than that of SQI. The difference was significant among the three groups (P < 0.01). The abnormal incidence of positive plasma motilin was 65.91% and 75.00% respectively. It is conjectured that the plasma motilin level in SYD was related to excitability of vagus nerve, disturbance of gastro-intestinal internal environment, indigestion and malabsorption of GI tract.

Adult↗
PubMed2005

[Familial pedigree analysis of Shen-yin deficiency syndrome in families with type 2 diabetes mellitus GU].

OBJECTIVE: To analyse the familial aggregation and genetic predisposition of Shen-yin deficiency syndrome (SYDS) in families with diabetes mellitus type 2 (DM2). Methods One hundred and forty-one DM2 patients were collected from 32 family lines in Nanjin area, in which the probands were differentiated as DM2 with SYDS. On them, genetic analysis on the characteristics of SYDS was conducted using pedigree analysis, morbidity and heritability of the first-degree relatives of the probands were calculated, and the action of familial SYDS factor on the genesis of the syndrome was assessed by multiple factors regression analysis. Results The morbidity rate of SYDS in the first-degree relatives of the probands was 33.71%, and the heritability, calculated by Falconer formula, was 80.6%. The fitting result of regression analysis showed that familial factor played an important role in SYDS genesis (OR = 5.61, P = 0.001), but DM2 itself is not an independent risk factor for it. Conclusion DM2 with SYDS shows the tendency of familial aggregation and genetic predisposition, genetic factor is associated with the genesis of the syndrome. Pedigree research is a good method for exploring the relationship between syndrome and genetic factor.

Adult↗
PubMed2004

[Regulatory effect of zengmian mixture on T-lymphocyte dysfunction in children with repeated lower respiratory tract infection of both Qi-Yin deficiency type].

OBJECTIVE: To explore the T-lymphocyte dysfunction in children with repeated infection of lower respiratory tract of both Qi-Yin deficiency type (RIR-QYD) and the immune regulatory effect of zengmian mixture (ZMM), to provide theoretical basis for the effective therapy. METHODS: Peripheral T-lymphocyte subsets and expressions of T-lymphocyte activating related surface molecules (CD3+/HLA-DR+ and CD3+/CD25+, etc.) in children with RIR-QYD, 31 of mild type and 28 of severe type cases, were investigated before administration of ZMM and after treatment of ZMM for 3-6 months (non-infectious stage), using immune fluorescent labelling and flow cytometric technique. RESULTS: In the patients with mild RIR-QYD, the expression rate of CD4+ and CD3+/HLA-DR+ activated T-cells before treatment were all obviously lowered, after 3 months treatment, the positive rate of CD4+, CD3+/HLA-DR- resting T-cell, CD3+/HLA-DR+ activated T-cell and CD3+/CD25+ express IL-2R T-cells were all obviously lowered, but after treatment for 6 months, only that of CD3+/HLA-DR+ activated T-cells was lower than that in the control group. In the patients with severe RRI-QYD before treatment, the expression rate of CD3+, CD4+, CD3+/HLA-DR-, CD3+/HLA-DR+ and CD3+/CD25+ all lowered, while after 3-6 months treatment, some recoveries were shown in these parameters but still lower than those in the control group. The total effective rate of ZMM for mild patients was 100%, and the markedly effective rate 78.9%, while for severe cases, the total effective rate was 90.9% and the markedly effective rate 68.2%. CONCLUSION: In patients with RIR-QYD, the T-cells decreased with activating dysfunction, the severity of disease is in accordance with the degree of T-cell activating dysfunction. ZMM shows markedly clinical effect in treating RIR-QYD and evident regulatory effect on T-cell dysfunction, but a long-term treatment is needed for the recovery of laboratory parameters.

Adolescent↗
PubMed2006

[Observation on therapeutic effect of "reducing south and reinforcing north" needling method on hypertension of type of yang-hyperactivity due to yin-deficiency].

OBJECTIVE: To observe therapeutic effect of "reducing south and reinforcing north" needling method on hypertension of type of yang-hyperactivity due to yin-deficiency, METHODS: Ninety cases of hypertension were randomly divided into a treatment group (n=59) treated with "reducing south and reinforcing north" needling method, and a control group (n=31) treated with capoten and aspirin. Their therapeutic effects on symptoms and blood pressure were compared. RESULTS: The total effective rate was 93.2% in the treatment group and 77.4% in the control group, the treatment group being better than the control group (P<0.05). After treatment, systolic pressure and diastolic pressure in the two groups decreased (P<0.05), but with no significant difference between the two groups in the therapeutic effect of reducing blood pressure (P>0.05). CONCLUSION: "Reducing south and reinforcing north" needling method and oral administration of capoten and aspirin have similar effect in reducing blood pressure, and the treatment group is better than the control group in improving symptoms.

Blood Pressure↗