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Results for “allergic sensitization”

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At least 19 recordsLinked to original sources
PubMed1979

Contact allergic sensitivity to chrysanthemum and the photosensitivity dermatitis and actinic reticuloid syndrome.

Of sixty-nine examples of the photosensitivity dermatitis and actinic reticuloid syndrome, nine were found to be allergically sensitive to chrysanthemum oleoresin extract. Although this extract showed evidence in vitro of a phototoxic action we were unable with in vivo studies to explain the connection between the contact allergic sensitivity and the photosensitivity. The fractions responsible for the in vitro phototoxicity appear to be different from those involved in the in vivo contact allergic sensitivity. This study provides further support for the view that in the photosensitivity dermatitis and actinic reticuloid syndrome contact allergic sensitivity is of importance.

Aged↗
PubMed1979

Contact allergic sensitivity to plants and the photosensitivity dermatitis and actinic reticuloid syndrome.

Contact allergic sensitivity to oleoresin extracts from Compositae plants was found to be usually present in individuals suffering from the photosensitivity dermatitis and actinic reticuloid syndrome. It was demonstrated in forty-seven out of fifty-five examples of this syndrome. These results provide support for the view that contact allergic sensitivity is an important aspect of the state of chronic photosensitivity in the middle-aged and elderly male.

Adult↗
PubMed1976

Influence of detergent on aerosol allergic sensitization with enzymes of Bacillus subtilis.

An anionic detergent, sodiumdodecylbenzenesulphonate, had an adjuvant effect upon aerosol allergic sensitization with subtilopeptidase A, a proteolytic enzyme of Bacillus subtilis. Both local and systemic antibody responses were accelerated and prolonged by use of the detergent. This adjuvant effect was only seen when an inactive form of the enzyme was used. The detergent, however, was able to potentiate early clinical responses upon initial exposure to the active enzyme.

Aerosols↗
PubMed2024

Networks of human milk microbiota are associated with host genomics, childhood asthma, and allergic sensitization.

The human milk microbiota (HMM) is thought to influence the long-term health of offspring. However, its role in asthma and atopy and the impact of host genomics on HMM composition remain unclear. Through the CHILD Cohort Study, we followed 885 pregnant mothers and their offspring from birth to 5 years and determined that HMM was associated with maternal genomics and prevalence of childhood asthma and allergic sensitization (atopy) among human milk-fed infants. Network analysis identified modules of correlated microbes in human milk that were associated with subsequent asthma and atopy in preschool-aged children. Moreover, reduced alpha-diversity and increased Lawsonella abundance in HMM were associated with increased prevalence of childhood atopy. Genome-wide association studies (GWASs) identified maternal genetic loci (e.g., ADAMTS8, NPR1, and COTL1) associated with HMM implicated with asthma and atopy, notably Lawsonella and alpha-diversity. Thus, our study elucidates the role of host genomics on the HMM and its potential impact on childhood asthma and atopy.

Humans↗
PubMed1979

Assessment of the influence of irrelevant IgE on allergic sensitivity to two independent allergens.

Serum samples from 31 patients sensitive to both ragweed and rye grass were quantitated for IgE specific for ragweed antigen E (AgE) and rye grass group I (rye I) antigens employing the previously described radioallergosorbent test (RAST) elution technique. IgE anti-AgE ranged from 0.4 to 320 ng/ml and comprised 0.4% to 14.2% of total serum IgE. The same sera contained IgE anti-rye I ranging from 7.9 to 1,168 ng/ml, comprising 1.6% to 29.6% of total serum IgE. A new theoretical parameter (RF), representing the percent of total IgE-Fc receptors of target cells occupied by allergen-specific IgE, was calculated for each IgE specificity by using the determinations of allergen-specific IgE antibody, total serum IgE, and assuming an equilibrium constant for binding of IgE molecules to basophils of 10(9)M-1. This "% occupancy" parameter correlated with skin test titration, basophil cell sensitivity, and hay fever symptom scores as well as, but not better than, the absolute values of allergen-specific IgE. This finding suggests that in most atopic patients, the quantity of irrelevant IgE plays a relatively minor role in determining allergic sensitivity to a given allergen. The implications of this finding are discussed.

Allergens↗
PubMed1978

[Redox processes during sensitization and allergic reaction to microbial antigens].

The effect of sensitization and delayed allergic response (DAR) to brucellosis antigen on the processes of glycolysis and dehydrogenase activity of Krebs' cycle was studied. The increasing sensitivity to Brucella was accompanied by inhibition of the dehydrogenase activity and increasing glycolysis. The changes were more pronounced in sensitization to living brucella. In DAR not only the dehydrogenase activity but also the processes of glycolysis were inhibited. Reduction of the aerobic fractions and excess of isoenzyme spectrum lactate dehydrogenase was observed both in sensitization and in DAR. Correction of biochemical shifts produced decreasing sensitization and inhibiting DAR symptoms.

Animals↗
PubMed1976

Allergic contact sensitivity to thiuram compounds in a hemodialysis unit.

An outbreak of dermatitis among patients in a hemodialysis unit was traced to thiuram compounds, most likely coming from the hemodialysis apparatus itself. Eight of the 21 patients in the facility had allergic contact sensitivity to various thiuram compounds. Testing of patients from other hemodialysis units, in which different hemodialysis equipment was used, did not disclose sensitivity or dermatitis. In the affected patients, allergic contact sensitization of the skin probably resulted from the systemic circulation of an antigen during hemodialysis.

Aged↗
PubMed1977

Allergic contact dermatitis from ultraviolet cured inks. Allergic contact sensitization to acrylates.

Eight men employed in the manufacture of ultraviolet cured inks developed allergic contact dermatitis predominantly on the exposed areas. Patch testing revealed sensitization to trimethylol propane triacrylate in seven employees, to 1,6-hexanediol diacrylate in six employees, to pentaerythritol triacrylatylate in four employees and to epoxy acrylate oligomers in three employees. Either cross-sensitization or concomitant sensitization may have accounted for the multiple reactions in several employees. One sensitized employee was patch tested with four different commercially available epoxy acrylate oligomers and reacted only to two, suggesting that variations possibly in chain length between these oligomers are important variables in the allergic reactions. The polyfunctional acrylic monomers and certain epoxy acrylate oligomers should be handled carefully to avoid the development of allergic contact dermatitis.

Acrylates↗
PubMed1979

Resistance to tick-borne Francisella tularensis by tick-sensitized rabbits: allergic klendusity.

Mammals become hypersensitive to ticks that feed upon them. That hypersensitivity was thought responsible for an observation that a large number of Francisella tularensis-infected Dermacentor variabilis failed to infect a rabbit previously exposed to ticks of that species. In a series of tests of that hypothesis, rabbits sensitized to ticks were often significantly more resistant than control animals to tick-borne tularemia. The conditions that determine the klendusity are thought to be variable and complex but the phenomenon must be of importance in the epidemiology of some arthropod-borne agents.

Animals↗
PubMedDate not supplied

Asthma problems in southern Italy: A statistical study of 2362 asthmatic patients.

In this report we have described the statistical results of a clinical study on 2362 asthmatic patients living mostly in the Naples area and observed in our Division of Respiratory Allergy from January 1976 to May 1978. All data have been analyzed by a computerized method using an Univac 1100 Computer. We have studied some aspects of the atopic syndrome in this population of Southern Italy: frequency of allergic sensitization according to endogenous and extrinsic factors (particularly Parietaria officinalis, a characteristic pollen of the Southern Italian Flora), etc. Finally we have presented the first results of our allergological investigation in Naples concerning the distribution of allergic sensitization according to air pollution of the patient's home.

Adolescent↗
PubMed1979

Allergic contact sensitization to the fungicide Maneb.

Three cases of contact dermatitis caused by Maneb, manganous-ethylene-bis (dithiocarbamate), are described. Maneb is used as an agricultural fungicide, and is also used in spraying solutions in horticulture and in flower shops. Patch testing with Maneb-related compounds revealed no regular pattern of cross sensitization.

Adult↗
PubMedDate not supplied

[Clinical and statistical study on the allergy of type 1 to mycetes (author's transl)].

From 1963 to 1977 the authors have examined 5700 patients; 11.5% of those positive to intradermal test were sensitive to Mold spores. 78 individuals showed allergic sensitivity exclusively to Mold spores; 89% were affected by bronchial asthma. Symptom onset was observed more frequently in subjects 30 to 50 years old. The authors intend to stress the important role played by the allergy to Mold spores in determining type 1 immunologic reactions.

Adult↗
PubMed1978

Oxatomide protects Trichinella spiralis infected mice from lethal anaphylaxis.

Infection with Trichinella spiralis in mice was accompanied by allergic sensitization as evidenced by anaphylactic death after intravenous injection of the antigen. Pre-treatment of the animals with oxatomide, a new orally active anti-allergic drug, resulted in significant protection of the animals; the lowest effective dose of the compound was 1.25 mg/kg orally. In contrast to cyproheptadine, oxatomide offered little protection against serotonin toxicity in mice. The present data suggest that, in this model of systemic hypersensitivity, the anti-anaphylactic effect of oxatomide can be attributed mainly to inhibition of release of allergic mediators.

Anaphylaxis↗