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At least 19 recordsLinked to original sources
PubMed1978

Atopy to dander from domestic animals.

Atopy to dander from domestic animals occurs rather frequently in atopic patients, especially danders from the cat, guinea-pig, horse, rabbit, and golden hamster. There is no clear sex difference. The age group in which the phenomenon is found most frequently is from 21 to 30 years. As in hay-fever patients during the season, we found a double-peaked frequency curve for the blood eosinophilia. Animal-dander atopy was diagnosed particularly in patients with asthma and/or with atopic eczema. The strength of skin reactions to a series of three tenfold dilutions of standardized test extracts appears to be a good index for the origin of clinical symptoms after contact with the relevant animals.

Adult↗
PubMed1977

Complexed IgE in atopy.

Evidence of circulating high-molecular-weight forms of IgE was found in 16 patients with hayfever and/or atopic eczema. This finding of what appears to be complexed IgE in the serum of atopic patients may help to elucidate the aetiology of atopy.

Antigen-Antibody Complex↗
PubMed1979

Atopy.

Atopy should be considered an immunological disorder that may result in several clinical conditions including respiratory disease, allergic dermatitis, food allergy dermatitis, and perhaps flea allergy dermatitis. The clinical course of the disease tends to fluctuate from season to season, which makes objective evaluation of injection therapy difficult. The disease is subject to both familial and environmental influences, and dogs maintain the atopic state throughout their life. The disease cannot be cured; however, a combination of symptomatic and specific injection therapy usually provides adequate control of the clinical signs. Owners of atopic dogs should appreciate that their pet has inherently itching skin, a cure for which is unlikely to be found.

Animals↗
PubMed1975

Nickel allergy and atopy in hairdressers.

A study of 35 hairdressers with hand eczema was made during an 18-month period. A total of 29 were test-positive to one or more substances in the standard series and/or to products from their working environment. 40% were allergic to nickel. The prevalence of personal atopy was higher in the nickel-negative than in the nickel-positive. Immunoglobulin E determination was not of assistance in attempts to differentiate between nickel-positive and nickel-negative hairdressers. In 72% the eczema had started before the age of 25 and in 23% after less than 1 year in the profession. The desire is expressed that all hairdressing products shall be labelled in respect to allergen contents, since 46% of the hairdressers reacted to one or more such agents.

Adult↗
PubMed2024

Networks of human milk microbiota are associated with host genomics, childhood asthma, and allergic sensitization.

The human milk microbiota (HMM) is thought to influence the long-term health of offspring. However, its role in asthma and atopy and the impact of host genomics on HMM composition remain unclear. Through the CHILD Cohort Study, we followed 885 pregnant mothers and their offspring from birth to 5 years and determined that HMM was associated with maternal genomics and prevalence of childhood asthma and allergic sensitization (atopy) among human milk-fed infants. Network analysis identified modules of correlated microbes in human milk that were associated with subsequent asthma and atopy in preschool-aged children. Moreover, reduced alpha-diversity and increased Lawsonella abundance in HMM were associated with increased prevalence of childhood atopy. Genome-wide association studies (GWASs) identified maternal genetic loci (e.g., ADAMTS8, NPR1, and COTL1) associated with HMM implicated with asthma and atopy, notably Lawsonella and alpha-diversity. Thus, our study elucidates the role of host genomics on the HMM and its potential impact on childhood asthma and atopy.

Humans↗
PubMed1975

Immunoglobulin E (IgE), an aid in the classification of occupational dermatoses?

During an 18-month period determinations of immunoglobulin E(IgE) in serum were made on all (631) new patients referred to the Department of Occupational Dermatology, Karolinska Sjukhuset, Stockholm. The mean for the entire series was 238 units/ml (U): 280 U for the 323 men and 196 U for the 308 women. The IgE values for the different age groups, clinical diagnoses and sexes are presented. About 20% of the patients with normal IgE (less than 250 U) had a history of atopy. On the other hand about 30% of the patients with pathological IgE value (greater than 1000 U) had no such history. No explanation of this rise of IgE without concurrent atopy was discovered despite detailed laboratory tests. Our impression is that the IgE value has a prognostic significance and that, especially for the question of choice or change of occupation in cases of dermatitis, the determination of IgE is of value.

Adolescent↗
PubMed1977

Serum IgE in dermatitis and dermatosis: an analysis of 497 cases.

Serum IgE values from 497 patients with various forms of dermatitis, dermatosis, and tinea pedis were analyzed statistically and compared with values from 95 normal controls. The median and geometric mean values were significantly elevated (except in acne without atopy, lichen planus, and tinea pedis), even after exclusion of patients with a history of atopy or of cutaneous reaction to food or drugs. Serum IgE levels and atopic dermatitis have a close correlation. A modest positive correlation (p approximately equal to .05) appeared between the log serum IgE level and peripheral blood absolute eosinophil count in 80 cases of atopic dermatitis. A unique group of adult nonatopic patients had acquired generalized dermatitis and markedly elevated serum IgE levels (greater than 12,000 ng/ml). Our results suggest that, in most common dermatologic disorders, elevated serum IgE is a secondary phenomenon rather than a primary causative factor.

Acne Vulgaris↗
PubMed1978

[Some atypical forms of eczema in children (author's transl)].

Among 466 children under the age of 12 years who presented with eczema in a 5-year period, 68 p. 100 were atopic. 136 had various atypical signs of atopy. 44 suffered from pityriasis alba of sufficient intensity to justify referral for this reason; 10 had the typical features of seborrhoeic dermatitis of infants. 27 suffered from "forefoot" eczema ("juvenile plantar dermatosis"). The course and characteristics of this condition are discussed and compared with the series recently described in the West of Scotland. Our cases were exactly similar except for an aggravation in the summer months and the fact that our cases responded poorly to topical corticosteroids alone though improved with coal tar. Atopy and contact sensitivity to shoe materials are rare in both groups. We feel that this may be classified as "frictional" dermatitis and agree with our Scottish colleagues that the introduction of nylon socks during the last ten years may be important.

Child↗
PubMed1977

The role of IgE in the immune response to neoplasia: a review.

The role of IgE in the immune response to neoplasia has received little attention despite suggestive evidence for an IgE response to tumor specific antigens. A complex interrelationship is known to exist between basophils, eosinophils, histamine, complement, and T cells. The latter cells are known to play a central role in the immune response to neoplasia and, in addition, are now considered important in the production and regulation of IgE, the molecule that may supply an important link between pharmacological and cellular dynamics of a successful anti-tumor response. The evidence for an IgE role in the immune response to tumors, the relationship between atopy and cancer, and the possible mechanisms whereby IgE could enhance tumor rejection are discussed in this review.

Animals↗
PubMed1978

Pancuronium and histamine release.

Both d-tubocurarine and pancuronium release histamine in the skin: both have been shown to cause bronchospasm after intravenous injection. It is unlikely that skin testing with either drug will detect an individual susceptibility to bronchospasm, except as a non-specific test for atopy.

Adult↗
PubMed2026

Tonsillar expression quantitative trait loci verify and expand genetic contributors to childhood atopic diseases.

BACKGROUND: The spectrum of causal variants, mechanisms, and immunologic gene networks that influence pediatric atopic traits is not completely understood. Human genetic variation associated with transcript abundance (expression quantitative trait loci [eQTLs]) can help to advance our understanding, yet prior work has focused on profiling immune cell populations collected from peripheral blood primarily in adult populations, leaving tissue-resident lymphocytes collected from children uncharacterized. OBJECTIVE: We sought to characterize gene expression of 4 populations of tonsil-derived immune cell types collected from pediatric patients. METHODS: We collected naive B, germinal center B, naive T, and T follicular helper cells from the discarded tonsils of 103 children across development (age range 1-19). Following genotyping and RNA sequencing of samples, we performed differential expression and eQTL analysis, then statistically linked eQTL signals to relevant atopic traits via colocalization. RESULTS: We found differentially expressed genes across cell types and identified 13,393 expression genes (eGenes) (1,793 eGenes not previously reported in similar datasets) influenced by 27,603 eQTLs (5,199 eQTLs not previously reported). We linked eQTLs to associations identified in pediatric and adult asthma and atopy traits, nominating 78 eGenes including TRAF3, ZBTB10, and JAZF1 in disease-relevant cell types. CONCLUSIONS: Our freely available resource exemplifies the importance of discovery in native tissues and across human development.

Expression quantitative trait locus↗
PubMed1976

Atopic disorders and adult coeliac disease.

A history of asthma, hay fever, and flexural eczema was significantly more common in patients with adult coeliac disease (A.C.D.) than in normal controls. Autoantibodies were also more common in A.C.D. First-degree relatives of A.C.D. patients were more likely than controls to have atopic disorders. A deficiency of local mucosal immunity due to abnormal IgA responses may underly this association between A.C.D. and atopy.

Adult↗