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At least 19 recordsLinked to original sources
PubMed2026

HPV Testing Versus Cytology for Cervical Cancer Screening Among Women 50 Years and Older: Evidence From the HPV FOCAL Randomized Controlled Trial.

Evidence on the comparative effectiveness of HPV testing versus cytology specifically in women aged ≥ 50 years who are approaching screening cessation remains limited. This analysis included 6471 women aged ≥ 50 at baseline screening in the HPV FOCAL randomized clinical trial. Women were randomly allocated to receive cytology (Control Group, n = 3248, 50.19%) or HPV testing (Intervention Group, n = 3223, 49.81%) at baseline, with co-testing at 48-month exit. We calculated incidence rates and risk ratios for CIN2+ detection over follow-up and compared missed lesions at exit by screening method. At the 48-month exit, CIN2+ detection was lower among HPV baseline-negative women than among those in the cytology group (1.61/1000 [95% CI, 0.52-3.76] vs. 3.15/1000 [95% CI, 1.51-5.78]; risk ratio, 0.51 [95% CI, 0.11-0.91]), reflecting higher baseline detection with HPV testing and fewer prevalent lesions at exit. Even with cytology re-screening at 2 years, 50% of CIN2+ cases were missed compared to 30% with HPV testing. After adjusting for age, education, smoking status, and lifetime sexual partners, the hazard ratio for CIN2+ comparing HPV to cytology was 0.44 (95% CI, 0.22-0.88). Among women aged ≥ 50 years, HPV primary screening was more effective than cytology at detecting CIN2+ lesions and was associated with a continued lower subsequent risk following a negative HPV test, supporting its use in cervical cancer screening programs in this age cohort.

Aged↗
PubMedDate not supplied

A sample preparation for automated cervical cancer screening.

A procedure for cluster disruption, cell dispersal and the production of a monolayer of cells from fluid suspensions for automated cell-scanning machines in an interactive system has been developed. The combination of 0.1 per cent dithiothreitol and 40 per cent alcohol in a balanced salt solution provides a self-limiting form of mucolysis which is completed by a controlled syringing regime to produce an optimally dispersed cell sample without the production of cell debris from the more effete cells. The induction of a positive charge on a microscope slide to attract the negatively charged cells has been achieved by coating the slides with the cationic polymer, polylysine. The cells appear to be sufficiently well attached to permit wet fixation and subsequent stain processing without loss. Quantitative data is given to demonstrate the superior cell presentation that is achieved by this new technique for automated scanning.

Diagnosis, Differential↗
PubMed1979

Preselection of alarms in a hybrid system for screening of cervical cancer.

In this report, a preselection of alarms in a system for automated screening of cervical cancer based on depositing the cell sample linearly as a "cell trace" on a tape and analyzing it at different decision levels with increasing complexity, and preliminary results on analyzing cervical material with this system are discussed. The "cell trace" is analyzed with the slit-scan technique. Six parameters are computed: 1) cellular diameter; 2) nuclear diameter; 3) nuclear fluorescence (acriflavin-Feulgen) as nuclear DNA; 4) cellular fluorescence; 5) nuclear to cytoplasm ratio (N/C ratio); and 6) nuclear density. At present, only nuclear fluorescence is used to define a decision boundary between normal and potentially atypical cells. Under this criteria the slit-scan analysis leaves 5% of the events in a sample that must be rechecked at a second decision level in normal cell samples. A further reduction is expected when several slit-scan parameters are used at the first decision step. All events declared suspicious will be investigated in more detail by a two dimensional image analyzing system where the fluorescence image is generated by a laser scanning system. Results obtained in preliminary experiments are discussed in this paper.

Computers↗
PubMed1979

[The effectiveness of cervical cytology screening for cervical cancer (author's transl)].

Cervical cytology screening was performed, between July 1971 and the end of 1976, on 503,870 specimens from 226,428 women. During this period the rate of positive or suspicious findings fell from 2.6% to 0.9%. The number of specimens judged suspicious for invasive carcinoma, carcinoma in situ or with severe dysplasia (among those women who had undergone serial examinations) was 5 per thousand for the first specimen, 2 per thousand for a subsequent second specimen, and 1.6 per thousand for a subsequent third specimen. The screening programme detected (later confirmed histologically) 272 cases of invasive carcinoma and 948 of carcinoma in situ or severe dysplasia. Related to the number of women screended at various ages, the frequency of carcinoma in situ and severe dysplasia had a peak between the 25th and 29th year of life, with a second, lower peak at around the 65th year. For invasive cervical carcinoma the frequency remained high into old age. The proportion of histologically proven cases of invasive carcinoma fell continuously from 1963/66, at 3.6 per thousand, until 1976, at 1.6 per thousand.

Adult↗
PubMed1977

Cervical cancer. Mass screening, incidence and mortality in Finland.

Since mass screenings were started in Finland, the incidence of cervical cancer has dropped by about 50 per cent. In the age groups 25-60 the decrease has been two thirds. Moreover, there has been a similar decrease in mortality in the younger age groups, in particular. All risk groups are not covered by the screening program, however. Cervical carcinoma is still a socio-medical and clinical problem particularly among elderly women.

Adult↗
PubMed1979

A screening system for cervical cancer cytology.

A system for screening cervical cytological preparations is described which employs the Leitz Texture Analyzer System (E. Leitz, Rockleigh, N. J.) quantitative staining with acridine orange, and a fluorescence standard. The instrumentation scans cells on microscope slides and detects objects which it interprets to be nuclei with excess total nuclear green fluorescence intensity (Previous results employing manual measurements have indicated that normal nuclei do not produce total nuclear green fluorescence greater than a specific absolute intensity level). Detected objects are identified by visual observation. Cells (102,000) from 65 patients (29 normal, 36 abnormal) have been examined. In each abnormal sample, at least one abnormal cell was detected. In over half of the samples, three or fewer other objects (e.g. clumps of polymorphonuclear leukocytes) were detected. These are easily distinguishable from single nuclei, and could be discarded by someone with minimal cytological training.

Cervix Uteri↗
PubMed1979

Study of women who did not respond to screening for cervical cancer.

Demographic and social factors influencing the population response to cervical screening programs have been studied. Age, marital status and, to a lesser extent, place of birth and socio-economic status were the most relevant factors. On the other hand, the reasons for nonparticipation were mainly the lack of information and motivation. Personal invitations, the recall of women who did not present on the first call, and the setting up of decentralized smear collection clinics proved to be useful tools to increase attendance.

Adult↗
PubMedDate not supplied

Cytologic screening for cervical cancer in southern Iran.

In an 11 year study of cytologic examinations from the southern part of Iran with a 99 percent Moslem population, the prevalence rate of invasive cervical carcinomas in 35,222 women screened for the first time was 2.3 per 1,000 examinations. With the initiation of a mass screening program begun in 1974, the rates of CIS and moderate and severe dysplasia rose threefold. These findings indicate that carcinoma of the cervix is an important problem in Iran, despite previous reports of the contrary. There is, thus, a clear need for encouraging and expanding the mass screening program which has been initiated in this country.

Adolescent↗