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Results for “internally mobile individuals”

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PubMed2026

Malaria Risk among Internally Mobile Individuals and Heterogeneous Mobility Patterns in Two Hypoendemic Communities: Implications for Malaria Elimination in the Peruvian Amazon.

BACKGROUND: Human mobility is increasingly recognized as a key factor influencing malaria transmission dynamics, particularly in low-transmission settings approaching elimination. This study aimed to assess mobility patterns and their association with malaria risk in two hypoendemic communities in the Peruvian Amazon. METHOD: A longitudinal study was conducted in the communities of Libertad and Urcomiraño (Mazán River basin). Monthly population screenings were combined with weekly active and passive case detection. A total of 678 individuals were enrolled. Mobility patterns were assessed through structured questionnaires, and social network analysis was used to characterize travel connections. Log-binomial regression analysis was applied to identify risk factors associated with malaria infection. RESULT: Internally, mobile individuals in Libertad showed a higher malaria incidence (>32.47 cases per 1,000 person-months) than those in Urcomiraño (<10.15 cases per 1,000 person-months). Travel networks were mainly connected to Mazan district and Iquitos city, followed by local streams such as Armas and Arahuana. Mobility was primarily driven by family, administrative and occupational activities. Male sex (PR = 2.15, 95% CI: 1.37 - 3.37) and age ≥15 years (PR = 1.98, 95% CI: 1.24 - 3.19) were significantly associated with malaria infection (p-value < 0.05). CONCLUSION: Internally mobile populations represent a key high-risk group sustaining malaria transmission in hypoendemic settings. Targeted interventions focusing on mobile individuals should be integrated into malaria elimination strategies in the Peruvian Amazon and similar endemic regions.

Malaria elimination↗

PubMed1978

Relationship of thermal quenching of protein fluorescence to intramolecular structural mobility.

Temperature dependence (over the range from 5 to 75 degrees C) of the fluorescence quantum yield--the parameter sensitive to the rapid (ns) mobility--has been investigated. For native proteins containing 1--2 fluorescing chromophores this dependence in the non-denaturing temperature range can be described by the equation 1/q = a + b . T/eta (a and b are temperature-independent constants, T is the temperature (K), eta is the viscosity of water, (cP). The linearity of the plot of 1/q vs. T/eta probably indicates that the internal mobility of different parts of the protein globule is limited by the diffusion of the molecules of the solvent. The peculiarity of individual protein structures is reflected by various absolute values of the constants of quenching rates. The results of the studies indicate that an analysis of the temperature dependence of the protein fluorescence quantum yield (thermal quenching curves) might be a new experimental approach to the study of the mobility of protein structures. The thermal quenching curves of proteins could be used as a measure of the temperature dependence of the rapid reverse structural mobility.

Models, Biological↗

PubMed2025

Fluorescence Loss After Photoactivation (FLAPh): A Pulse-Chase Cellular Assay for Understanding Kinetics and Dynamics of Viral Inclusions.

Influenza A virus (IAV) relies on host cellular machinery for replication. Upon infection, the eight genomic segments, independently packed as viral ribonucleoproteins (vRNPs), are released into the cytosol before nuclear import for viral replication. After nucleocytoplasmic transport, the resulting progeny vRNPs reach the cytosol, accumulating in highly mobile and dynamic viral inclusions that display liquid properties. Being sites postulated to support IAV genome assembly, the biophysical properties of IAV inclusions may be critical for function. In agreement, imposing liquid-to-solid transitions was demonstrated to impact viral replication negatively. Therefore, screening for host factors or compounds able to alter the material properties may provide the molecular basis for how influenza genomic complex forms as well as identify novel antivirals. Conventional techniques employed to investigate biomolecular condensates' material properties include fluorescence correlation spectroscopy, raster image correlation spectroscopy, single molecule or microrheology particle tracking, and Fluorescence Recovery After Photobleaching (FRAP). These approaches allow measuring molecular dynamics in systems that do not move very much. However, the analysis of highly mobile intracellular condensates, such as IAV inclusions, poses significant challenges as these structures not only constantly move within the cell but also exchange material, fusing, and dividing, rendering the quantitation of internal rearrangements and diffusion coefficients of molecules within condensates inaccurate. As an alternative, we opted for measuring the kinetics and the exchange of material between IAV inclusions using the Fluorescence Loss After Photoactivation (FLAPh) technique. It involves pulse photoactivation of individual or pools of viral inclusions in the cell, and chasing over time in photoactivated and non-photoactivated regions. This approach is suitable for quantifying the movement and spatial distribution of components within inclusions over time, enabling the determination of both the distance and speed from a specific cellular location. As a result, this method allows the quantification of decay profiles, half-lives, decay constant rate, and mobile and immobile fractions in viral inclusions. It, therefore, enables high throughput screenings for compounds or host factors that affect this dynamism and indirectly allows assessing the material properties of IAV inclusions.

Humans↗

PubMed1979

Ring current effects in the conformation dependent NMR chemical shifts of aliphatic protons in the basic pancreatic trypsin inhibitor.

Previously, a highly refined crystal structure and energy refined atomic coordinates were obtained for the basic pancreatic trypsin inhibitor, as well as numerous individual resonance assignments in the 1H NMR spectrum. These data were now used to investigate the contributions from the local ring current fields of the aromatic rings to the overall conformation dependent chemical shifts in this globular protein. A program was written which allowed the consideration of certain aspects of internal mobility of the protein, and the different commonly used ring current equa tions were compared. These studies indicate that ring current shifts are the dominant contribution to the observed conformation dependent chemical shifts of the peripheral aliphatic side chain protons. On the other hand, it appears that ring current shifts do not make dominant contributions to the conformation dependent shifts of the backbone alpha- and amide protons or the aromatic protons in the inhibitor. On the basis of the empirical calibration with the peripheral aliphatic side chain protons, the Johnson-Bovey ring current equation was selected for an analysis of the ring geometries of two prolines in the inhibitor.

Amino Acids↗

PubMed1977

An electron microscopic cytochemical study on concanavalin A binding sites and their mobility in normal and cystic fibrosis fibroblasts in vitro.

Concanavalin A (Con A) binding sites were visualized ultrastructurally in the cultured fibroblasts from cystic fibrosis patients, obligatory heterozygotes, and normal individuals by peroxidase labeling technique. Con A binding sites were localized as a continuous layer on the external side of the plasma membrane in fixed fibroblasts of the three genotypes. In living cells, Con A induces both lateral and vertical movements of binding sites as expressed by cap formation and internalization of the plasma membrane. Fibroblasts of the three genotypes responded similarly to Con A treatment and failed to show significant detectable differences.

Binding Sites↗

PubMed1977

Fractures and dislocations encountered by the general surgeon: general principles.

The definitive treatment selected for the care of a fracture is dependent upon what will offer the best cosmesis and function for the individual patient. Closed reductions and immobilization which require the joints to be in abnormal positions may offer an anatomic reduction but after the fracture is healed, joint function may be poor. Consequently, immobilization in the functional position with early motion and acceptance of some deformity is often better in terms of the ultimate use of the extremity. Traction treatment which requires prolonged recumbency is dangerous in the elderly because of the threat of thromboembolic phenomena and pneumonia. Therefore, open reduction and internal fixation with early mobilization of such patients is preferred. The type of treatment used is based on an evaluation of the entire patient and not just the radiographic interpretation of the fracture.

Adult↗

PubMedDate not supplied

Zickel nail fixation of bilateral subtrochanteric fractures.

The introduction of the Zickel nail has provided a significant advance in the treatment of subtrochanteric fractures. The device allows early mobilization and a high rate of union. In a 24-year-old man, the device was used bilaterally for subtrochanteric fractures, thus obviating the need for prolonged hospitalization and promoting early ambulation, and return to work. It must be emphasized that a bilateral operation for subtrochanteric fracture is a formidable procedure but can be accomplished in an otherwise healthy individual.

Adult↗

PubMed1977

Gains and losses of vascular surgery patients.

Understanding the gains and losses experienced by the patient and his family aids in assessing the psychologic sequela of peripheral vascular surgery. Placing the patients' individual responses into the categories of: function, self-directiveness, self-definition, and future orientation offers a way to conceptualize the meaning of the illness to the patient. Factors such as physical mobility and integrity, self-concept and body image greatly influence the adaption process. Conceptually, these elements provide a framework upon which to base nursing intervention. Careful observation, skillful interviewing, and interpersonal support are appropriate nursing considerations when caring for the patient with peripheral vascular disease. The goal of adaption is a successful reintegration of the whole person,which comes from an acceptance of both gains and losses experienced in surviving peripheral vascular surgery.

Activities of Daily Living↗

PubMed2026

Longitudinal Clinical, Physiological, and Molecular Profiling of Female Patients With Metastatic Cancer: Protocol and Feasibility of a Multicenter High-Definition Oncology Study.

PURPOSE: A substantial proportion of patients receiving genomically matched therapies do not achieve clinical benefit, underscoring the influence of nongenetic factors on cancer outcomes. High-Definition Oncology (HDO) proposes integrating longitudinal, multimodal patient data-spanning clinical, molecular, physiological, and behavioral domains-to enable truly individualized cancer care. This manuscript describes the HDO study design, framework, and feasibility results in women with metastatic cancer. METHODS: We initiated a prospective, multicenter observational study (HDO study; ClinicalTrials.gov identifier: NCT06590506) enrolling 300 female patients with newly diagnosed metastatic breast, lung, or colorectal cancer. Here, we report the study design, standardized workflows, prespecified feasibility criteria, and early internal pilot results. Eleven data modalities are collected longitudinally, including tumor and germline genomics, germline epigenomics, gut microbiome, blood and stool metabolomics and proteomics, exposome characterization, wearable-derived physiological monitoring, digital footprint assessment, medical imaging, and patient-reported outcomes. Standardized workflows govern clinical procedures, data acquisition, biospecimen processing, and quality control across all participating sites. RESULTS: Feasibility was evaluated in the first 30 participants (10% of planned accrual). Patients completed 100% of scheduled clinical visits, 97.4% of planned plasma collections, 80.7% of stool samples, and all tumor biopsies. Wearable devices captured activity, heart rate, sleep, and blood oxygen saturation data during 95.0%, 84.2%, 90.6%, and 70.7% of total patient-days, respectively. Biospecimens met predefined quality control metrics across all molecular modalities. Engagement with mobile applications for pain and emotion reporting exceeded 80%. CONCLUSION: The HDO study demonstrates the feasibility of comprehensive, longitudinal, multimodal data collection in women with metastatic cancer. This internal pilot establishes an integrated framework for future analyses aimed at characterizing disease trajectories, defining molecular and physiological determinants of outcomes, and developing patient-specific computational models.

Humans↗

PubMed1979

[Arterial monoaminocytes of the base of the brain in vertebrates].

By Falck's method monoaminocytes of the arteries in the encephalon base were studied in Teleostei (Anarhichas lupus, Eleginus navaga, Leuciscus brandti Liza soiuy in amphibians (Rana temporaria, Rana semiplicata, Bufo bufo), in reptiles (Testudo horsfiedli, Trionyx chinensis) and in birds (blue rock pigeon, hen). Specific and individual peculiarities in chromaffinocyte, labrocyte and melanophore distribution were revealed in the vertebrate cranial arteries. In all the animals studied chromaffin cells are more frequent in the lateral olfactory artery. Their concentration decreases towards cranial, caudal branches of the internal carotid artery, the main and internal carotid arteries. The greatest amount of chromaffinocytes was found in the cranial arteries of Anarhichas lupus, then comes Eleginus navaga, Leuciscus brandti and Liza soiny Concentration of melanophores in fishes increases with enlargement of the vascular diameter; these cells are more abundant in the arteries of Anarhichas lupus and in less amount in Eleginus navaga, Leuciscus brandti and Liza. Pigmented cells are more abundant in the internal carotid artery and its cranial and caudal branches than in lateral, olfactory and main arteries of fishes. On the contrary, in amphibians, the main artery contains a maximal concentration of melanophores. In the tortoise cranial arteries, there are only single cells of this type, and birds have no such cells. Labrocytes occur in the greatest concentration in the tortoise cranial arteries and in other vertebrates they are scarce or absent. As a whole, the role of the local endocrine link in regulation of the brain arteries mobility decreases in the following way: fishes--amphibians--reptiles--birds.

Amines↗