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At least 19 recordsLinked to original sources
PubMed1992

[Morphological and immunohistochemical quantitative analysis of dysplasia in ulcerative colitis. II. Immunohistochemical quantitative analysis].

Mapping specimens of 6 cases of ulcerative colitis included adenocarcinoma invaded into submucosa (invasive carcinoma) were made and immunohistochemical quantitative analysis of ras p21, an oncogene product and secretory component were examined in invasive carcinoma, severe and moderate dysplasia of ulcerative colitis. Large intestinal carcinoma invaded into submucosa, colonic adenoma and normal mucosa were examined as the control. Index values of Staining Density (ISD) and of Staining Gland (ISG) of ras p21 demonstrated significantly higher values in invasive carcinoma, severe and moderate dysplasia of ulcerative colitis than adenoma (P less than 0.01). ISG of secretory component in moderate dysplasia and adenoma showed significantly high value compared with severe dysplasia and invasive carcinoma of ulcerative colitis (P less than 0.05). The collective evidence indicates that severe dysplasia falls into the same category with invasive carcinoma of ulcerative colitis and may be defined as carcinoma in situ. Moderate dysplasia was also defined as carcinoma in situ or borderline lesion.

Adenocarcinoma↗
PubMed1979

Quantitative analysis of dendritic branching. I. Simple formulae for the quantitative analysis of dendritic branching.

Dendritic branching of neurons may be quantitatively studied using applications of graph theory. Dendritic ramifications may be considered as 'forests' of planted, stemmed, binary 'trees' with simple mathematical properties. Two fundamental numbers, that of dendritic tips and that of dendritic stems, usually suffice to quantify the dendritic branching of one neuron as, in most cases, they allow the computation of all other numbers of dendritic points and segments.

Animals↗
PubMed1992

[Morphological and immunohistochemical quantitative analysis of dysplasia in ulcerative colitis. 1. Histological mapping specimen and morphological quantitative analysis].

Mapping specimens of 6 cases of ulcerative colitis included adenocarcinoma invaded into submucosa (invasive carcinoma) were made and Index value of Nucleus-Gland (ING) of invasive carcinoma, severe and moderate dysplasia in ulcerative colitis was measured and compared with one another. Large intestinal carcinoma invaded into submucosa, colonic adenoma and normal mucosa were examined as the control. Spatial relations of invasive carcinoma and dysplasia in ulcerative colitis were also examined. Severe and moderate dysplasia as well as large intestinal carcinoma invaded into submucosa showed significantly higher values of ING than adenoma (P less than 0.01). Invasive carcinoma and severe dysplasia of ulcerative colitis showed significantly higher values of ING than moderate dysplasia (P less than 0.01). Severe dysplasia was located around the portion of of invasive carcinoma of ulcerative colitis. Severe dysplasia falls into the same category with invasive carcinoma of ulcerative colitis because of the same value of ING and spatial translation each other. Moderate dysplasia was defined as borderline lesion because of the mean value of ING between severe dysplasia and adenoma.

Adenocarcinoma↗
PubMed1977

[Brain organization of Amia, Lepisosteus and Polypterus: comparative morphology and quantitative analysys].

The quantitative study of the brain of Amia, Lepisosteus and Polypterus leads to results which are compared to those previously got on the Sturgeon and three species of Tleosts (the Rainbow Trout, the Carp and the Ballan wrasse). The volumetric analysis has been applied at first to the whole brain (encephalization indices) and later to the main subdivision of the brain: telencephalon, diencepahlon... (relation indices and relative volumes). Some result are discussed in regard to the various opinions expressed about the phylogenetic affinities of the studied species. According to the brain organisation, the Bichir (Polyterus) seems to be at a relatively high level of evolution, and no relationship can be expected with the Chondrosteans. Amia and Lepisosteus show a common general brain pattern, but some peculiarities allow to consider Amia as more primitive than Lepisosteus--although the osteological characteristics and the scale structure lead to put together the first one and the Teleosts.

Animals↗
PubMed1979

Eye movements in schizophrenia: a quantitative analysis.

A quantitative comparison of smooth pursuit eye movements of acute and chronic schizophrenics was made. Horizontal, vertical, diagonal, and pendulum tracking targets with constant or variable velocity were presented. The frequency of saccades as well as the magnitude of the spatial and temporal error during tracking was significantly greater among schizophrenics than among normals. Yet the differences between acutes and chronics were not generally significant. Performance differences were generally unaffected by the type of stimulus. The frequency of nontracked half-cycles and eye blinks was greater for chronics than for acutes or normals, and greater for acutes than normals, suggesting that sustained voluntary attention was more difficult for schizophrenics in general and chronic schizophrenics in particular. A distinctive pattern of saccade bursts was observed in the fixation and tracking records of schizophrenic subjects. These bursts were suggestive of an oculomotor deficit.

Acute Disease↗
PubMed1992

The nucleus raphe magnus of the cat. II. Quantitative analysis of axosomatic synapses.

Quantitative analysis of axosomatic synapses in the nucleus raphe magnus of the cat showed great variations in their number, shape and size. There exist some relations between the size of perikarya and the number and size of the synaptic knobs. In the small neurons the number and size of synapses was smaller than in the large neurons, but there exist some exception from this rule. The observed morphological differences can be ascribed to different functional significance of various neurons.

Animals↗
PubMed1992

Brain pH and lactic acidosis: quantitative analysis of taurine effect.

A quantitative analysis of taurine effect (facilitation of acid handling capacity of brain in response to anoxia/hypoxia by high levels of cytosolic taurine) was performed utilizing multinuclear (1H, 31P) in vivo nuclear magnetic resonance (NMR) spectroscopy and in vitro titration analysis. Taurine effects observed in vivo showed excellent quantitative agreement with the predicted values estimated based on brain taurine levels. The study confirmed that high levels of cytosolic taurine indeed facilitate acid buffering capacity of brain and this taurine effect can be readily explained by the physical, and need not involve metabolic, properties of taurine. Taurine appears to be a key component of the brain cytosol system in the fetus.

Acidosis, Lactic↗
PubMed1978

The cranial base in fetal Macaca nemestrina: a quantitative analysis of size and shape.

The applicability of Fourier analysis to quantitate the midsagittal cranial base has been demonstrated utilizing fetal Macaca nemestrina. This methodology accurately measures the irregular form of the endocranial profile, minimizes the effects of size, and maximizes shape differences. This method provides a quantitative dimension to the descriptive analysis of shape change previously observed with a combined histologic and cephalometric analysis.

Animals↗
PubMed1978

Microchromatography of hemoglobins. VIII. A general qualitative and quantitative method in plastic drinking straws and the quantitative analysis of Hb-F.

The microchromatographic procedure for the quantitative analysis of the hemoglobin components in a hemolysate uses columns of DEAE-cellulose in a plastic drinking straw with a glycine-KCN-NaCl developer. Not only may the method be used for the quantitative analysis of Hb-F but also for the analysis of the varied components in mixtures of hemoglobins.

Chromatography, DEAE-Cellulose↗
PubMed1992

Oscillations in glycolysis: multifactorial quantitative analysis in muscle extract.

A multifactorial quantitative analysis of oscillations in glycolysis was conducted in the postmicrosomal supernatant of rat muscle homogenates incubated in the presence of yeast hexokinase. Oscillations in adenine nucleotides, D-fructose 1,6-bisphosphate, triose phosphates, L-glycerol 3-phosphate, 3HOH generation from D-[5-3H]glucose, NADH and L-lactate production were documented. The occurrence of such oscillations were found to depend mainly on the balance between the consumption of ATP associated with the phosphorylation of D-glucose, as catalyzed by both yeast and muscle hexokinase, and the net production of ATP resulting from the further catabolism of D-fructose 6-phosphate, as initiated by activation of phosphofructokinase. The oscillatory pattern was suppressed in the presence of D-fructose 2,6-bisphosphate. It is proposed that the quantitative information gathered in this study may set the scene for further studies in extracts of cells other than myocytes, e.g. hepatocytes and pancreatic islet cells, in which no oscillation of glycolysis was so far observed.

Adenine Nucleotides↗
PubMed1975

Quantitative analysis of the carotid sphygmogram in atherosclerosis.

A study has been made, by means of quantitative analysis, of the changes in the CSG of 355 persons-131 healthy, 112 with ischemic heart disease and 112 with hypertension. The quantitative analysis includes: (1) coefficient of declination, pointing to the declivity of the anacrotic limb; (2) coefficient of propulsion, pointing to the time of formation of the maximum peak and (3) level of indentation, pointing to the height of the valve notch. These 3 indices regularly increase along with progressive induration of the arterial wall and serve as quantitative criteria for a more accurate differentiation of the separate types of CSG used in clinical practice.

Adolescent↗
PubMedDate not supplied

A quantitative analysis of the afferent innervation of the organ of corti in guinea pig.

A quantitative analysis of the afferent innervation of the organ of Corti was made on normal and vestibular nerve-sectioned guinea pigs. Section of the vestibular nerve at the internal auditory meatus provided an efficient means of eliminating the efferent innervation to the cochlea without significant loss of afferent fibres. Nerve counts on normal and de-efferented animals revealed that about 10-15 % of the cochlear afferent innervation supplies the outer hair cells. The remaining 85-90% of afferent fibres innervate the inner hair cells. As in cats, all tunnel spiral bundle fibres and upper tunnel crossing fibres were efferent to outer hair cells. Since unmyelinated fibres in the osseous spiral bundle were not counted, quantitative analysis of the efferent innervation to inner hair cells could not be made. However, a significant loss of myelinated fibres in the osseous spiral lamina after vestibular nerve section confirms that many myelinated efferent fibres are present in this region.

Animals↗
PubMed1992

Quantitative analysis in single photon emission tomography (SPET).

Quantitative analysis can improve the sensitivity and specificity of single photon emission tomography (SPET) procedures, as well as reduce inter- and intraobserver variabilities. Quantification of the radioactivity distribution is the ultimate goal of SPET. In this review we consider the basic requirements for an optimum three-dimensional reconstruction of the radionuclide distribution to enable quantification. Attenuation and scatter correction as well as varying resolution are the major problems. In the older SPET systems quantification was hampered by the lack of system sensitivity and sufficient computer power. Therefore, the imaging system was often assumed to be shift invariant and linear and the attenuation throughout the object uniform. More sophisticated solutions have been proposed and with more or less success implemented, but not for application in daily practice. Knowledge (measurement) of the attenuation is often required. New generation SPET systems employing multi-detectors and super minicomputers will ease the implementation of these solutions.

Humans↗
PubMed1977

The early phase of insulin release in man--a new method for quantitative analysis.

A method is presented for the quantitative analysis of early insulin release in man. There were measured arterial insulin levels after glibornuride administered intravenously. The mathematical procedure has been modified: Modification I is based on the assumption that early insulin release represents a wave like insulin delivery, modification II is based on the assumption that this insulin bolus is immediately followed by a slower insulin release which must be distinguished from the second phase of insulin release. For the calculations there was used a "primary insulin space" derived from experiments with exogenous insulin. The results of calculations were varying up to 1.5 units of early insulin release in healthy volunteers receiving glibornuride with dosages varying up to 50 mg. The value of the presented method for examinations of insulin release for theoretical and clinical purposes is discussed.

Adult↗
PubMed1977

Quantitative analysis in the oxytocin challenge test.

A quantitative analysis of the oxytocin challenge test (OCT) was carried out in 305 women to evaluate: (1) the intrauterine pressures evoked during the oxytocin infusion, (2) when fetal heart rate (FHR) decelerations are likely to occur, (3) the type and amount of decelerations which are significant, and (4) what clinical events and laboratory parameters correlate with the OCT. If contractions are evoked at a rate of three per 10 minutes, the pressure profile mimics normal labor. The first FHR deceleration is likely to occur between the second and third effective contraction. A deceleration/contraction ratio greater than or equal to 10% significantly forecasts an abnormal FHR during parturition and an increased chance of a cesarean section.

Adult↗
PubMed1992

[Quantitative analysis of cerebrospinal fluid dynamics in syringomyelia using cine MRI with pre-saturation].

Some reports show the qualitative analysis of cerebrospinal fluid (CSF) pulsation in the subarachnoid space and the syrinx using cine magnetic resonance imaging (MRI). However, few reports studied the quantitative analysis of CSF pulsation. We report here the results of quantitative analysis of CSF pulsation using the cine MRI with pre-saturation pulse. Using flow phantom, we calibrated the correlation between the true velocity and calculated velocity acquired from the movement of pre-saturated low signal. Three cases of syringomyelia with Chiari malformation, two cases of traumatic syringomyelia, and three normal volunteers were examined using this technique, and we could obtain time-velocity curves of CSF in both subarachnoid spaces and syrinx. Although obvious pulsation of CSF was observed in the syrinx of all Chiari malformations, no pulsation of CSF was observed in the syrinx of traumatic syringomyelia. CSF in the syrinx moves upward in the early systolic cardiac cycle, downward in the systolic cycle, and upward again in the diastolic cycle. Patterns of CSF pulsation in syrinx were similar to those in the subarachnoid space, but "phase" of these pulsations differed from case to case. These results suggest the close relationship between CSF pulsation in the syrinx and CSF obstruction at the cranio-vertebral junction. Dissociation of the "phase" of CSF pulsation in the syrinx and subarachnoid space may be significant in the analysis of the pathogenesis of syringomyelia.

Adult↗
PubMed1992

Prediction of reversible perfusion defects by quantitative analysis of post-exercise electrocardiogram-gated acquisition of technetium-99m 2-methoxyisobutylisonitrile myocardial perfusion scintigraphy.

The aim of this study was to assess the reliability of the quantitative analysis of regional wall thickening with electrocardiographic-gated technetium-99m 2-methoxyisobutylisonitrile (SESTAMIBI) in predicting the reversibility of stress-induced perfusion defects. The assumption was that a preserved resting wall thickening in a segment with stress-induced perfusion defect would predict normal resting perfusion. Twenty-five patients with suspected coronary artery disease underwent planar stress-rest SESTAMIBI scintigraphy. The wall thickening was quantitatively evaluated as percentage increase in counts from diastole to systole; a ratio defined as the wall thickening index (WTI) between patient and normal profile (mean - 2 SD) below 1 was considered abnormal. Improvement of the perfusion pattern at rest was observed in 76% (54/71) of segments with a stress-induced perfusion defect; 90% of these segments had a (WTI) greater than 0.8. Five segments (9%) showed fixed perfusion defects despite a WTI value greater than 0.8. In conclusion, quantitative analysis of regional wall thickening by electrocardiographic-gated SESTAMIBI identifies segments with reversible perfusion defects; this may overcome the need for studies at rest and may direct the detection of hypoperfused but viable myocardium.

Coronary Disease↗