PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “seizure”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed1976

Ontogenetic studies of seizure patterns and seizure activities induced by cortical focus.

Ontogenetic studies of epileptogenic process were carried out in albino rats ranging in age from birth to 45 days. Experimental epilepsy was produced by two different procedures and the results were compared with each other. Tungstic acid gel was applied to the motor area of the left side of the cortex, and the following results were obtained. The latency of the seizure appearance was long during 10 days after birth, became progressively short thereafter and reached the minimum in about 20 days of age, and gradually returned to the adult level again by 45 days of age. No abvvious seizure was exhibited until five days of age. Seizure patterns developed from tonic or twitch-like jerky convulsion (10 days old) to rhythmic or clonic type of seizure (13 days old), and the seizure patterns similar to those in the adult rat were observed in about 20 days of age. Cortical seizure activity was initially observed in about 10-day-old rats; single high amplitude slow wave appeared and small spikes became superimposed on it in the course of maturation. Atypical spike and wave complexes were observed after 20 days of age. Electrical stimulation was applied to the left cortical motor area by constant current stimulator, and the following seizure patterns were observed: No obvious seizure could be elicited in newborn rat, whereas from three days of age, tonic seizure of the whole body, and from seven days old twitch-like convulsion of extremities were observed. In ages from 10 to 20 days, seizure induced by electrical stimulation was mainly tonic in pattern; extension of forelimbs and flexion of hindlimbs in most cases were observed before 13 days old, but both fore-and hindlimbs were extended therafter. Tonic-clonic seizure patterns were exhibited after 20 days of age. From these results, it was considered that tonic convulsions and high voltage slow cortical seizure activites were produced from the activites of the local cortical neuronal connections, and rhythmic and/or clonic seizure patterns and spike and wave seizure activities were elicited from the more complex, i.e. cortico-subcortical neuronal circuits. Possible contributing factors for the determination of seizure susceptibility in immautre rats were also discussed.

Age Factors↗
PubMed1978

Alterations in learning performance in the seizure-prone baboon: effects of elicited seizures and chronic treatment with diazepam and phenobarbital.

A comparison was made of the effects of chronically administered diazepam and phenobarbital with those of elicited seizures on repeated acquisition learning in 3 prepubertal Papio papio. The learning task required the baboons each day to perform different sequences of lever presses on a three-lever behavior panel. Middle dose levels of both diazepam and phenobarbital were found to improve learning performance relative to base-line control levels, as measured by total errors, efficiency, and time required to complete chains of various lengths to a fixed criterion. The doses were well within therapeutically relevant seizure control and clinical blood level ranges. Higher doses of both drugs generally abolished the performance gains achieved with the lower doses. Seizures elicited twice weekly for 2--3 weeks, or daily for 7 days, induced no overall decrement in performance. Cyclicity in subsequent performance was, however, induced by each individual seizure during the twice weekly seizure period, and learning performance was found to be significantly worse at 42 hr than at 18 hr after each seizure. Implications of these data for acquisition of learning in the epileptic are discussed.

Animals↗
PubMed1976

[Experimental study on epilepsy using a "kindling preparation". Correlation between septal seizure development and psychomotor seizure].

The seizure development was investigated in seven septal kindled cats for examining a participation of septal area in psychomotor epilepsy. Daily electrical stimulation (mean: 33.5 days) of septal area could lead to the "kindled" generalized convulsion. Six stages of behavioral seizure development were distinguished: 1) attention reaction, 2) the above and immobility, 3) the above and autonomic manifestation, 4) the above and facial twitching, head nodding, 5) the above and tonic extension of contralateral forepaw, 6) the above and generalized clonic convulsions. Self-sustained after-discharge and independent interictal spike discharge appeared in the hippocampus in stage 2 or 3, in the amygdala and the globus pallidus in stage 3 or 4, and also in the ventromedial hypothalamic nucleus in stage 5. Positive transference phenomenon was confirmed in bilateral hippocampus, amygdala and globus pallidus. These findings show the progressive dissemination of secondary epileptogeneses in these secondary brain structures during the septal seizure development. Electrographic and behavioral seizure development mentioned above were completely identical to those in the hippocampal seizure that we have reported previously. It is concluded that psychomotor epilepsies may not only be triggered by the hippocampal and amygdaloid foci but by the septum and its related structuresfoei.

Amygdala↗
PubMed1975

Cerebrospinal fluid acid-base and lactate changes after seizures in unanesthetized man. I. Idiopathic seizures.

The natural course of acid-base changes in arterial blood and lumbar cerebrospinal fluid of patients admitted after major motor seizures was correlated with simultaneously determined lactate levels. In 10 patients with idopathic seizures studied less than 3 hours after the seizure, arterial lactate and cerebrospinal fluid lactate were elevated in association with a mild arterial metabolic acidosis. The elevated cerebrospinal fluid lactate persisted despite a return to normal of the arterial lactate in seven patients studied between 3 and 6 hours after the seizure. All values were normal in five patients studied more than 4 days after a major seizure.

Acid-Base Equilibrium↗
PubMed1975

Effects of tetrahydrocannabinols on kindled amygdaloid seizures and photogenic seizures in Senegalese baboons, Papio papio.

Intraperitoneal injections of delta 8-tetrahydrocannabinol (THC) and delta 9-THC failed to affect myoclonic response to photic stimulation in Senegalese baboons (Papio papio). However, both isomers of THC exerted dose-related antiepileptic effects upon established kindled convulsions provoked by electrical stimulation of amygdala in the same species. Delta 9-THC was more potent than delta 8-THC, in terms of both antiepileptic effects and general toxicity. The antiepileptic effects of the THC isomers appear to be due mainly to the suppression of propagation of the induced afterdischarge to distant cerebral structures, although high doses also seem to suppress afterdischarge at the site of stimulation.

Amygdala↗