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At least 19 recordsLinked to original sources

Symptom Networks and Core Symptoms in Patients with Solid Tumors Undergoing Chemotherapy: A Systematic Review.

OBJECTIVES: To summarize symptom network characteristics in patients with solid tumors undergoing chemotherapy and synthesize evidence on core symptoms, bridge symptoms, and temporal associations. METHODS: We systematically searched eight databases through October 2025 to identify studies that applied symptom network analysis to adults with solid tumors receiving chemotherapy. Eligible studies assessed symptoms using cross-sectional, longitudinal, or interventional designs. Two reviewers independently screened articles and extracted data on study characteristics, symptom assessment, and network outcomes. Methodological quality was assessed using the National Institutes of Health Study Quality Assessment Tool. RESULTS: Twenty-seven studies involving 13,452 participants were included, yielding 79 symptom networks. Fatigue was the most frequently identified core symptom (10/20, 50%), whereas sadness, lack of appetite, and nausea each occurred in 10% of studies, with variation across cancer types, treatment phases, and latent classes. Bridge symptoms included disturbed sleep, lack of appetite, and dry mouth (2/7, 28.6%). Studies evaluating temporal associations found that symptoms such as sadness, dyspnea, somnolence, and dry mouth predicted subsequent changes in appetite, distress, nausea, and other outcomes. Strength metrics showed acceptable stability (correlation stability coefficients: 0.28-0.83). CONCLUSIONS: Fatigue was frequently identified as a central symptom across studies, largely reflecting evidence from breast cancer studies. Core symptoms varied across cancer types, treatment phases, and latent classes, suggesting heterogeneity. IMPLICATIONS FOR NURSING PRACTICE: These findings highlight the importance of considering relationships among symptoms in clinical care. Focusing on key symptoms such as fatigue, while tailoring management strategies to cancer-specific symptom patterns, may support more effective symptom management.

Humans

Back symptoms in nursing aides in a geriatric hospital. An interview study with special reference to the incidence of low-back symptoms.

The incidence of back symptoms, particularly in the lumbar region, was investigated in 267 female nursing aides in a geriatric hospital. The overall incidence of low-back symptoms was 46.8%. Low-back insufficiency was present in 40%, lumbago in 18.4% and sciatica in 7.6%. Nursing aides with low-back symptoms had a higher incidence of cervical and thoracic spine symptoms than those without low-back symptoms. Recurrence of low-back symptoms had been common, appearing in 82%. Nursing aides with lowback symptoms considered their work more stressful to the spine than those without low-back symptoms. No relationship was found between different kinds of lifting technique and the incidence of low-back symptoms.

Adolescent

Symptom disclosure to male and female physicians: effects of sex, physical attractiveness, and symptom type.

Seventy-five subjects (50 male and 25 female) rated their willingness to disclose symptoms of a personal nature, general nature, and mental illness nature to male and female physicians whose photographs had been pretested as being either physically attractive or physically unattractive. Increased willingness to disclose was related to (1) the more physically attractive physicians, (2) general as compared to personal and mental symptoms, (3) same-sex match-ups between patient and physician, especially when (4) disclosing personal or mental illness symptoms or concerns. The sex of the physician per se had no influence on patient's willingness to disclose symptoms. Implications are drawn concerning the patient's assignment to or choice of physician based on sex. Patient education and training in symptom disclosure as well as physician's skill building in facilitating symptom disclosure are also indicated.

Attitude to Health

[Epidemiological studies on the symptoms due to strawberry culture in the vinyl-house. 1. An analysis of subjective symptoms by working conditions and constitution of the farmers (author's transl)].

An epidemiological survey focused on farmers engaged in vinyl-house culture of strawberry was carried out among the inhabitants of a farming village. For avoiding residential and habitual factors, all residents (851 in number) over 12 years of age in the area were inquired about symptoms, personal and family histories. There were no marked difference in age and sex among three groups, i.e. farmers with and without vinyl-house culture and people with no relation to farming in this area. Incidence of one of the inquired symptoms were 54% and 45% in farmers with and without strawberry culture in vinyl-house respectively, and 34% in the non-farming people. This difference became more larger up to 83% in the strawberry farmers of allergic constitution. Symptoms found more in the farmers than the other were headache, dizziness, conjunctivitis, rhinorrea, sneeze, palpitation and neuralgia, and the last four symptoms were more marked among farmers in charge of strawberry culture. Incidence of the allergic symptom consisting of conjunctivitis, rhinorrea and sneeze was more marked among the persons of allergic constitution . In conclusion, health effects of strawberry culture in vinyl-house in farmers can be look upon from three aspects; overwork, a particular stance during the work and allergic responses to the dust in the vinyl-house.

Adolescent

[Digitalis intoxication: specifity and significance of cardiac and extracardiac symptoms. part II. Patients with extracardiac symptoms of digitalis intoxications (author's transl)].

In 1148 cases the serum digoxin concentration (SDC) was correlated with the extracardiac signs of digitalis intoxication. There is a considerably overlap of SDC levels of patients with and without extracardiac signs of toxicity even though the mean SDC's of these two groups differ significantly. An increasing percentage of clinical intoxicated patients with increasing SDC levels was found at digoxin concentrations of 2.0 ng/ml and higher. At lower SDC levels patients with and without extracardiac signs of digitalis intoxication did not differ significantly in their mean SDC but in mean age and in mean creatinine concentration indicating that at least part of the symptoms in these patients might be due to a more severe illness. We could show that many of the extracardiac signs of digitalis intoxication are also seen in patients with impaired kidney function at low SDC levels and may lead to a wrong diagnosis. The most common complaint in patients with SDC's of 2.0 ng/ml and more is nausea (39.4%), followed by tiredness (30.4%), dizzyness (23.7%), vomiting (23.1%), headache (16.0%), visual disturbances (13,5%), colour (yellow) seeing (6;7%), diarrhea (4.2%) and severe neuro-psychiatric disturbances (3.8%). In patients with digitalis-induced arrhythmias the sequence of symptoms is the same only with a somewhat higher percentage rate. Only about one half of the patients with digitalis-induced arrhythmias and SDC values up to 2.5 ng/ml showed also extracardiac signs of intoxication. Therefore these signs are not to be taken as early symptoms of digitalis intoxication. Divided into subgroups (patients with/without digitalis-induced arrhythmias, patients with SDC values of more/less than 2.0 ng/ml) the patients with and without extracardiac signs of digitalis toxicity are compared with each other in regard to: mean body height and weight, concentration of digoxin, potassium and creatinine, digoxin dosage and mean age. The greatest differences were found between patients with combined cardiac and extracardiac signs of intoxication and patients with neither cardiac nor extracardiac signs of intoxication: These intoxicated patients are of significantly higher mean age and lower body weight, their mean concentration of digoxin and creatinine and the digoxin dosage administered are significantly greater, but there is no significant difference in potassium concentration. An important group of patients, namely the elderly with impaired kidney function, are especially prone to develop digitalis intoxication. In this group, however, the extracardial symptoms are of little benefit in the diagnosis of digitalis intoxication. In these patients rhythm disturbances and intoxication-like symptoms are frequently caused by other reasons. In most cases the SDC value can clarify the diagnosis without withdrawal of the drug.

Age Factors

Influence of demographic characteristics on two measures of depressive symptoms: the relation of prevalence and persistence of symptoms with sex, age, education, and marital status.

Respondents from community and inpatient populations were asked to recall for the preceding week the prevalence (presence of symptom at any time) and persistence (presence of symptom for five to seven days) of 16 symptoms associated with depression. The rates were adjusted for four-variable combinations of sex, age, education, marital status, and clinical status. For the majority of symptoms, statistically significant associations were found between prevalence and sex, age, and marital status and between persistence and education. These results suggest that white women, young adults, and those not currently married have a higher prevalence of transient depressed affect than those in the other categories of each variable, while the less well-educated are at greater risk than those in other education categories of having the depressive syndrome requiring therapeutic intervention.

Adolescent

The timing of menstruation-related symptoms assessed by a daily symptom rating scale.

A daily symptom rating scale (DSRS) was constructed from items previously used in questionnaires and rating scales measuring menstrual symptoms. The DSRS was found to have adequate reliability and validity. The profiles of symptom intensity of 65 women, mainly hospital staff, median age 19, during one menstrual cycle, with particular emphasis on the premenstrual week and menstruation are reported. Significant differences in ratings during the cycle were found. Ratings increased during the premenstrual week and were maximal on the days immediately preceding and following the onset of menstruation. No abrupt decline in ratings was found when menstruation commenced. Results were compared with answers to a menstrual distress questionnaire, previously administered to the same women and the questionnaire results were in good agreement with DSRS results on the day of maximum symptom intensity (the day immediately before or the day immediately after the onset of menstruation.

Adolescent

[Meningiomas from the clinical viewpoint of first symptoms, duration of anamnesis and neurologic-ophthalmologic deficiency symptoms].

UNLABELLED: First symptoms, period of case history, neurological findings and ophthalmological findings were evaluated in 123 patients operated on because of meningiomas. Typical first symptoms were headache (42%), fits (30%) and impaired vision (28%). 70 per cent of the patients showed a case history period of up to two years, 11 per cent one of more than five years. In 25 per cent this period was less than six months. In two cases the symptoms set in an acute form. Paresis was found in cases of meningiomas of the falx convexity region. A papilledema was found in 41 per cent, reflex differences in 30 per cent and hemiparesis in 13 per cent of the patients. LOCATION: parasagittal (28 patients), falx (10 patients), convexity (31 patients), tentorium (6 patients), posterior cranial fossa (4 patients). Neither a short period of the case history nor the absence of neurological and ophthalmological changes can exclude a meningioma.

Adult

Character defenses and biofeedback. The problems of symptom chronicity and symptom removal.

One aspect of biofeedback treatment with chronically incapacitated persons concerns their resistance to getting better. In effect, the removal of their symptom is equivalent to undercutting a characteristic way of relating to themselves and to the world, and hence, is opposed. Even though many biofeedback procedures are impressively effective, the therapist must watch for another symptom reemerging in the place of the older somatic complaint, or for psychologically regressive attempts to preserve one's character defenses.

Adolescent

What does the symptom "palpitation" mean? - Correlation between symptoms and the presence of cardiac arrhythmias in the ambulatory Ecg.

The correlation between palpitations and arrhythmias was examined using 319 long term Ecgs of 167 patients. Furthermore, we attempted to determine the shortest possible recording time permitting the correct diagnosis of an arrhythmia and ST-segment changes. 31 arrhythmias (9.7%) were correctly identified by our patients; On the other hand, while there were 20 palpitations (39%) that could not be related to an arrhythmia we recorded 39 instances in which these same patients missed an arrhythmia. Tachycardias and multiple ventricular extrasystoles were most likely identified. Most of the rhythm disturbances (89%) appeared during the first 12 hours and all of the ST-segment changes eventually seen (100%) occurred until the end of 8 hours of recording. This study shows that ths symptom "palpitation" is a poor indicator of underlying rhythm disturbances. In the documentation of arrhythmias and/or ischemic ST-segment changes 8 to 12 hours of recording should usually be sufficient.

Arrhythmias, Cardiac