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Biomedical subjects

A A Bialasiewicz

Publications and source records attributed to A A Bialasiewicz.

At least 91 records · Page 5Linked to original sources
PubMed1988

[Pseudo- "toxic lens" syndrome over the course of 4 years caused by staphylococcus epidermidis endophthalmitis].

A 79-year-old female patient presented with recurrent severe iridocyclitis after extracapsular cataract extraction and implantation of a PMMA posterior chamber lens in 1983: In April, June, July, September, October and December 1984 as well as April and August 1985 and January and April 1987, the uveitis appeared without a hypopyon and was diagnosed as a "toxic lens syndrome". Consequently, IOL explantation followed by anti-inflammatory and - intermittently - immunosuppressive therapy was performed in October 1984 with a resulting improvement in vision. In June 1987, the patient presented with a full-blown bacterial endophthalmitis, which required immediate pars plana vitrectomy. Lens cortex material and capsule residues were removed. Staphylococcus epidermidis was cultured from the vitreous aspirate using enrichment techniques. Antibiotic topical and systemic therapy was performed according to the antibiotic sensitivity test and resulted in a complete cure of the intraocular inflammation.

Aged↗
PubMed1988

[Tectonic keratoplasty in perforated corneal ulcer in Sjögren's syndrome (report of 10 eyes in 8 patients)].

The authors report on eight patients with perforated corneal ulcers (six unilateral, two bilateral) and Sjögren's syndrome associated with rheumatoid arthritis. Five patients were evaluated serologically at the time of perforation. Circulating immune complex-like material, positive latex and Waaler-Rose tests, C-reactive protein and pathologic complements C3 and C4 were found in all patients. One patient with features clinically similar to those seen in the patients with Sjögren's syndrome had an iridocyclitis associated with HLA-B 27, with circulating immune complexes but negative latex and Waaler-Rose tests. Penetrating keratoplasty was performed in three eyes, eccentric keratoplasty in one, a penetrating mini-keratoplasty in four, and a tectonic sclerokeratoplasty in three. The keratoplasties had to be repeated in one case after ten years because of endothelial decompensation, in another case three months postoperatively because of a bacterial corneal ulcer, and in a third for optical reasons. After follow-up periods of between 12 and 1 1/4 years it was established that even though the interventions were sometimes extensive, the prognosis was good provided rheumatologic check-ups were thorough.

Adult↗
PubMed1987

Evaluation of diagnostic tools for adult chlamydial keratoconjunctivitis.

Conjunctival smears and serum specimens of 150 patients with presumed chlamydial keratoconjunctivitis were evaluated over a period of 16 months and compared to age- and sex-matched healthy controls. Sensitivity, specificity, and predictive values of fluorescent monoclonal antibody (FMAb) direct tests, IgG single antigen tests for the detection of serum antibody (IgG-IFT), and IgA and IgG immunoperoxidase tests (IgA-IPAs and IgG-IPAs) for serum antibody were compared to McCoy cell culture techniques in a nonoptimized clinical setting. Thus, FMAb sensitivity was 100%, specificity was 52%, and predictive value was 30%. IgG-IFT sensitivity was 94%, specificity was 67%, and predictive value was 37%. IgA-IPA sensitivity was 100%, specificity was 70%, and predictive value was 40%. The IgG-IPA was sensitive but nonspecific. With respect to the current epidemiologic situation in our area, FMAb and IgA-IPA in addition to McCoy cell culture techniques may represent valuable diagnostic tools for the detection of chlamydial disease.

Adult↗
PubMed1987

[Several years' course of an oculogenital Chlamydia infection].

A 46-year-old woman had been suffering from recurrent bilateral keratoconjunctivitis, vascularized corneal scars, and incipient pannus vasculosus for five years. Oculogenital chlamydial disease was diagnosed by Giemsa stains, McCoy cell culture, and serum IgG immunofluorescent techniques. Isolates from cervical smears were positive for C. trachomatis in cell cultures. Systemic therapy with doxycycline 200 mg per day for 14 days resulted in resolution of the acute symptoms and no further recurrences. The patient's partner was also treated with tetracyclines. Because of reduction of vision, a lamellar corneal grafting was performed.

Chlamydia Infections↗
PubMed1987

[Etiology of corneal ulcers with special reference to bacterial genesis].

The authors report on 134 patients (141 eyes) seen between May 1982 and December 1985 with corneal ulcers with or without hypopyon. Eight patients (11 eyes) had a facial palsy, 7 (7 eyes) a varicella zoster infection, 1 (2 eyes) a marginal ulcer ("furrow keratitis") associated with collagenosis, 29 (29 eyes) an ulcerative keratitis with endophthalmitis, 1 (2 eyes) a pemphigoid-associated ulcer and 90 (92 eyes) a herpetic infection. Pathogenic bacterial strains were isolated from 20 patients: 10 coagulase-positive Staphylococcus aureus (4 coinfections), 3 Pseudomonas aeruginosa (1 coinfection), 2 Proteus mirabilis (1 coinfection), 2 Escherichia coli and Enterobacter cloacae, Citrobacter freundii and beta-hemolyzing streptococci as well as enterococci in one case each, and non-hemolyzing streptococci and alpha-hemolyzing streptococci in two cases each as coinfections. A comparison of the range of bacterial strains of postoperative endophthalmitis and kerato-/conjunctivitis with bacterial corneal ulcers revealed a high percentage of gram-negative organisms in the latter. Laboratory work-up should include microscopy, agar plating and differentiation as well as antibiotic sensitivity testing and modern immunofluorescent direct techniques. Management includes bactericidal topical and systemic antibiotic regimens as well as surgical procedures if necessary, e.g., perforating tectonic and mini-keratoplasty, and conjunctival flapping followed by lamellar keratoplasty.

Anti-Bacterial Agents↗
PubMed1987

[Ophthalmologic findings in 11 q-deletion syndrome].

A 5-year-old boy with deletion of the long arm of chromosome 11 presented with trigonocephaly, bilateral ptosis, epicanthus, antimongoloid lid axes, and bilateral iris coloboma. In order to avoid complication by a torticollis a Guyton-Friedenwald fadenoperation was performed. In 1981 Grosse et al. listed among the pediatric symptoms retarded development, ventricular septum defect, mitral stenosis, and skeletal and urogenital anomalies.

Blepharoptosis↗
PubMed1987

[Diagnosis of ocular Chlamydia infections by direct detection].

Conjunctival smears of 75 patients with a presumptive diagnosis of oculogenital chlamydial infection were evaluated with the monoclonal antibody direct test (SyvaMerck and Orion Research). 69 isolates were correlated with McCoy cell cultures and serum IgG immunofluorescent tests. Sensitivity (100%) and specificity (56-76%) of the monoclonal antibody direct test was comparable to data from recently published studies on genital smears.

Antibodies, Monoclonal↗
PubMed1987

[Phlyctenular keratoconjunctivitis in bacterial epibulbar infections].

Phlyctenular keratoconjunctivitis is now a rare clinical entity. Histologic staging has been updated by infection-immunological findings: phlyctenules have been identified as delayed-type cellmediated immune responses involving bacterial, mycobacterial, chlamydial, fungal or parasitic pathogens. Establishment of a correct diagnosis should include conjunctival and systemic work-ups for pathogenic agents. Case reports of three patients are presented.

Adult↗
PubMed1987

Binding patterns of lectins to human retinoblastoma cells: preliminary findings.

Lectin binding patterns of cultivated retinoblastoma cell lines Y-79 and Mac-7 and freshly isolated tumor tissue revealed membrane-associated sugar residues NAcD-Gal, D-Gal, mannose, and D-GlcNAc. Compared to normal retinal pigment epithelium, LCA positively bound to retinoblastoma cells. Similarities in the glycoconjugate patterns with LV-B-1 cells are shown.

Carbohydrates↗
PubMed1987

[The cat as a possible infection source for Chlamydia psittaci keratoconjunctivitis in humans].

Acute follicular keratoconjunctivitis in a 25-year-old female patient was diagnosed as an infection with Chlamydia psittaci supposedly originating from a household cat with similar symptoms. The diagnosis was based on clinical symptoms, the appearance of Chlamydia-psittaci-specific IgM in the patient and the cat, and excluded other pathogenic agents. Chlamydiae organisms could not be isolated, probably due to prior antibiotic treatment. Two weeks of continuous treatment led to complete recovery of the patient and the cat. Other zoonotic infections of conjunctivitis in cats and keratoconjunctivitis in man caused by Chlamydia psittaci are mentioned.

Adult↗
PubMed1986

Epidemiology of chlamydial eye diseases in a mixed rural/urban population of West Germany.

4260 conjunctival specimens of 2850 outpatients with keratoconjunctivitis of presumed infectious etiology were studied. Two thousand six hundred sixty-eight specimens (63%) revealed growth of bacteria, and 80 (2%) growth of fungi. One hundred ninety-nine specimens (5%) were McCoy cell culture or direct stain (monoclonal antibody or Giemsa) positive for Chlamydia trachomatis. two patients had a C. psittaci infection (ELISA techniques). In patients with keratoconjunctivitis of bacterial etiology, overall incidence of McCoy cell culture-proven chlamydial infections was 7%; in the 20 to 30-year age group it was 12.5%. Simultaneous infections of chlamydiae and other bacteria were seen in 34 patients. Since sensitive and specific tests to diagnose chlamydial infections are available, ophthalmologists may be able to prevent these infections by agent-specific antibiotic therapy.

Adult↗
PubMed1986

[Keratoconjunctivitis caused by Chlamydia psittaci].

A 25-year-old female patient suffering from acute follicular keratoconjunctivitis with epithelial and subepithelial corneal infiltrates was examined. Antibodies of the IgM class directed against C. psittaci were found. Infection due to C. trachomatis was ruled out by serology (ELISA) and negative isolation attempts. The patient's cat had rhinitis and conjunctivitis and a positive C. psittaci specific IgM antibody titer. Systemic application of tetracycline resulted in fast resolution of symptoms in both the patient and her cat.

Adult↗
PubMed1986

[Group B streptococcal panophthalmia in neonatal infection].

Hemolyzing streptococci of group B were isolated from an ulcerative keratitis in a 14-day-old girl (gestational age: 39 weeks, birth weight: 3230 g) suffering from septicemia. The differential diagnosis includes all bacteria and virus species able to penetrate the intact cornea, e.g. Pseudomonas sp., N. gonorrhoeae and Herpes simplex virus II. Perinatal infection may be via the birth canal.

Bacteriological Techniques↗