PubMed Health⌕ Search

Biomedical subjects

A A Iakovlev

Publications and source records attributed to A A Iakovlev.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

[Pathogenesis of the arterial hypertensive syndrome in Itsenko-Cushing disease].

The indices of central hemodynamics and renin-angiotensine-aldosterone system, as well as their relationship, were studied in patients with aggravated Icenko-Cushing's disease. A stable high arterial pressure, a raised total peripheral resistance, a decreased cardiac index, an increased blood corticotrophin, cortisol and aldosterone levels and an enhanced plasmatic renin activity were revealed. It is suggested that activation of the renin-angiotensin-aldosterone system stimulates the development of arterial hypertension in patients with Icenko-Cushing's disease, taking into account a significant role of this system in alteration of the central hemodynamics indices.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Neurotensin in Itsenko-Cushing disease].

The results are presented on studying the blood neurotensin concentration in 68 patients with Icenko-Cushing's disease and in 5 persons with adrenocortical tumors. Neurotensin fasting content was determined by radioimmunoassay after insulin, glucose, peritol and parlodel administration and following the treatment with chloditane-, chloditane-cyproheptadine complex, a combination of chloditane and a dopaminergic drug. It was found that the blood neurotensin concentration is enhanced in the active stage of Icenko-Cushing's disease. Marked changes were not observed in the blood neurotensin concentration of healthy subjects and patients with Icenko-Cushing's disease under stress, provoked by insulin hypoglycemia and after glucose injection. Different sensitivity to peritol and parlodel was seen in a half of patients with an increased blood neurotensin concentration. During clinical remission of Icenko-Cushing's disease under chloditane and combined chloditane-peritol treatment the blood neurotensin level returned to normal, remaining increased in patients treated with chloditane and a dopaminergic drug.

Adolescent↗
PubMedDate not supplied

[Comparison of the morphological changes in the capillaries and the state of the renin-angiotensin-aldosterone system in diabetes mellitus].

Microangiopathies were the earliest and most frequent complications of diabetes mellitus; however, their pathogenetic mechanisms are still obscure. Electron microscopic study of the capillaries of the gastrocnemius was conducted in 11 patients with diabetes mellitus at the state of decompensation and in 8--of clinical compensation; blood aldosterone level and the plasma renin activity were determined by the radio-immunological method. A marked thickening of the capillary basal membrane (the most marked sign of microvascular affection) was revealed in all the patients under study; there was also an increase in the aldosterone level and renin activity. The mentioned changes were to the greatest degree (statistically significant values) expressed in the patients at the state of decompensation. Analysis of the data obtained revealed a direct correlative relationship of these changes.

Adult↗
PubMedDate not supplied

[Potential use of the antiserotonin preparation cyproheptadine (peritol) in Itsenko-Cushing disease].

Experiments on male rats have shown that the inhibitory effect of peritol on the hypothalamohypophyseal-adrenal system (HHAS) is determined both by its influence on the regulatory mechanisms of the CNS and direct action on secretion and, possibly, synthesis of steroids. The degree of the antiserotonin and the HHAS-inhibiting effects depends on the frequency of drug administrations rather than on its dose. The experimental studies made it possible to successfully apply peritol to the treatment of inpatients suffering from Icenko-Cushing's disease. Almost 60% of the inpatients manifested a remission, which was confirmed by the reduced blood content of ACTH, hydrocortisone and aldosterone.

Adolescent↗