Biomedical subjects
Publications and source records attributed to A A Turdyev.
In the experiments with white rats it was found, that the inhalation of freon 114B2 at CL16, CL50, CL84 levels caused the changes in seasonal values of the energy activity in mitochondria. The action of the freon 114B2 caused disturbances in regulation of the mitochondria activity and desynchronization of seasonal rhythms of their energy activity.
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The study revealed that after benzene-induced intoxication (CI50) there occurred low-energetic and energetic phase shifts in rats' liver mitochondria. The content of lipid peroxidation products of the above organellas varied analogously. The time following intoxication being longer, higher were the general level of liver mitochondria energetic activity and the content of lipid peroxidation products. The highest level was recorded on the 3d day after benzen-induced intoxication. On the 16th day complete recovery of liver mitochondria was not recorded.
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Functional properties of CFUs have been studied in intact and regenerating liver of mice. According to a number of properties (proliferative activity, character of colony growth) CFUs in the liver are similar to CFUs in the peripheral blood and, probably, make the same population. In the regenerating liver relative contents of CFUs 3-5 days after a partial resection is substantially increasing. Concentration of CFUs (endogenic) increases significantly also in a locally injured and regenerating lobe, comparing to the intact lobe that is in the same organ. The transplanted bone marrow CFUs prevail in number in the regenerating liver over the intact liver. It is concluded that increasing contents of CFUs in the regenerating liver depend mainly on its creased property to invade and/or to hold the extrahepatic CFUs.
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The morphological composition and some of biochemical factors of turtle blood, as well as correlation between the former and the latter were examined. It was revealed that the turtles and mammals differed in the factors under consideration. The data obtained are interpreted in the light of the formation of the organism's response to the environmental exposures.
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The implantation of a bone marrow fragment of intact mouse donors below the kidney capsule of irradiated (7 Gy) recipients leads to the formation of the haemopoiesis locus that somewhat exceeds, by mass and cellularity, the new-formed locus of control animals. The U-2 fraction of a tortoise spleen extract administered to recipients irradiated with the same dose increases the mass and cellularity of the haemopoiesis locus by 2.2 and 4.9 times respectively.
It was shown that 80% of tortoises survived on day 45 after gamma irradiation (60Co, 4.2.10(2) Gy) in conditions of long-term (6 h) anoxia, against 5% survived after irradiation in normal conditions. It is suggested that the modifying effect of ionizing radiation under anoxic conditions is mainly associated with the decreased rate of peroxidation processes in membrane phospholipids and the enhanced radioresistance background during the first decade following irradiation.
A combined exposure to hypokinesia (21 days) and gamma-radiation (8 Gy) was shown to produce a synergistic effect on the level of endogenous radiosensitizers in mitochondria resulting in a low-energy shift: the compensatory reserve of the hepatocytes' energy system was utilized with a 242 per cent efficiency. The molar cholesterol/phospholipid ratio decreased. The lipid phase homeoviscosity increased significantly in microsomes.
Intraperitoneal administration of a spleen extract from Testudo horsfieldi and its U-2 fraction increases the number of endogenous splenic haemopoietic colonies. The U-2 fraction administered to irradiated (4 Gy) mice increases the number of bone marrow CFUs. Bone marrow cells of exposed (4 Gy) mice preincubated in vitro with the U-2 fraction also increase the number of exogenous colonies in the recipient's spleen.