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Biomedical subjects

A Adeniyi

Publications and source records attributed to A Adeniyi.

31 records · Page 2Linked to original sources
PubMed1976

Plasma immunoglobulin levels in Nigerian infants in the first year of life.

Serial estimations of plasma immunoglobulins IgG, IgM and IgA were undertaken in the first year of life of healthy Nigerian infants by the single radial immunodiffusion method. High levels of IgG present at birth dropped below half their values in the first month of life and remained low for about four months after which a sustained rise was observed although birth levels were not attained at 1 year of age. IgM was low at birth and IgA was absent but was detached at one month. Both IgM and IgA rose rapidly in the first four months of life which is in keeping with immunological competence and primary antibody response to various subclinical infections in infancy.

Humans↗
PubMed1975

Rickets in Nigerian children--response to vitamin D.

The findings in 20 cases of nutritional rickets treated on an out-patient basis with oral calciferol and calcium gluconate are reported. Attention was paid to their clinical, biochemical and radiological responses. If was noted that presentation at the hospital out-patient department was always delayed until there were obvious and sometimes severe deformities in the children. Biochemical changes noted during the early phase of treatment showed an initial fall in the level of serum calcium and plasma phosohorus and a rise in the serum alkaline phosphatase. About three months after initiating treatment, calcium and phosphorus reverted to normal levels but serum alkaline phosphatase still remained high. Twelve of our cases (60 per cent) suffered from protein calorie malnutrition of the marasmic type and showed an apparent resistance to vitamin D therapy in what may be regarded as normal dosages. Response was however, achieved with substantial increase in the amount of vitamin given. There was a striking sex difference in the ratio of 15 males to five females indicating that males are more likely to develop nutritional rickets than females when subjected to predisposing environmental conditions. Vitamin D resistant type of rickets was not encountered in this study.

Alkaline Phosphatase↗
PubMedDate not supplied

Sarcoma botryoides in a Nigerian female infant.

A case of sarcoma botryoides has been reported in a 10-month-old Nigerian female infant. The tumor has behaved true to form by its location and histologic appearance. The prognosis in this child is still guarded, as chemotherapy has been the only form of treatment. Although she has been under observation for one year now, there has been no local recurrence of the tumor.

Cyclophosphamide↗
PubMedDate not supplied

Correlates of emergency response interval and mortality from severe anaemia in childhood.

A retrospective study to determine the influence of blood transfusion emergency response interval on Mortality from childhood severe anaemia was carried out. Admission records of all children with severe anaemia over a 5-year period was reviewed. Those who either died before transfusion or got discharged against medical advice were excluded. A total of 5790 patients were admitted during the 5 year period. Ten percent (10%) had severe anaemia. Malaria, the leading cause of anaemia in this series, was found in 80% of the patients. Twenty patients (3.3%) died before transfusion while 50 discharged from the hospital against medical advice. There was male preponderance. Ages 2-5 years were the peak age group for severe anaemia. No patient had haematocrit less than 5% but 20 (4.2%) had heaematocrit above 20%. The hospital stay for majority (74.8%) of the patients was 72 hours or less. Mortality (Case fatality) increases with increase in transfusion emergency response interval within 24 hours. Based on the transfusion emergency response interval versus mortality curve, a mortality risk assessment scores were derived for use in clinical practice to determine the risk of dying from the disease. We recommend that national or hospital policy on blood transfusion be enunciated to ensure that all patient with severe anaemia get transfused within 2 hours of diagnosis.

Adolescent↗
PubMedDate not supplied

Studies on the immunopathology of the nephrotic syndrome associated with Plasmodium malariae. 1. Serum levels of an immune adherence inhibitor.

A comparative study of the serum levels of an immune-adherence inhibiting factor was carried out on serum samples from eighty-seven nephrotic syndrome children, twenty-eight nephrotic adults, 202 normal school children, 116 blood donors, twenty-five falciparum malaria children and 172 patients with miscellaneous diseases. Low titres (1/32 and below) of the factor were present in sera from 63.2% of the nephrotic children 60.7% of nephrotic adults and 60.0% of children malaria, as compared with 30.7% of the normal children, 25.5% of the patients with miscellaneous diseases and 41.4% of the blood donors. There is a significant difference between nephrotic children and normal children with low titres (P less than 0.05). Furthermore, 36.8% of the nephrotic children had serum titres of 1/4 or less, as compared with 6.4% of normal children. The serum factor is tentatively referred to as 'C3b-inase'. Its similarity to conglutinogen-activating factor (KAF) and its possible role in the pathogenesis of the immune-complex nephropathy of childhood nephrotic syndrome associated with malaria are discussed.

Adolescent↗