Biomedical subjects

A B Drake-Lee

Publications and source records attributed to A B Drake-Lee.

57 records · Page 4Linked to original sources

PubMed1982

Nitrous oxide and middle ear pressure. A study of induction methods in children.

The effects of different methods of induction of anaesthesia on middle ear pressure were investigated in healthy children. An increase in middle ear pressure associated with positive pressure ventilation with a bag and mask was demonstrated. When nitrous oxide was used, middle ear pressure increased by 39 mmH2O/minute in spontaneously breathing patients and 63 mmH2O/minute in those who were ventilated. Maximum pressures, with venting through the Eustachian tube, could be reached within 5 minutes in the latter group.

Anesthesia, Inhalation↗

PubMed1982

Clinical symptoms, free histamine and IgE in patients with nasal polyposis.

29 adult patients with nasal polyps were studied. The clinical symptoms and atopic profile were compared with both the level of histamine and IgE found in polyp fluid. The high concentration of free histamine found in polyp fluid was probably pathological, and local IgE was present in greater amounts than expected by simple diffusion. There was no evidence that clinical hypersensitivity is associated with higher concentrations of IgE and histamine in polyp fluid; it is possible that mechanisms other than an IgE-mediated response could cause degranulation of mast cells in nasal polyps.

Amine Oxidase (Copper-Containing)↗

PubMedDate not supplied

Computerized measurement of ciliary beat frequency.

We describe how ciliary beat frequency (CBF) of human respiratory epithelium in vitro can be robustly and quickly measured. The proven photometric technique has been improved by using a microcomputer to calculate and display the results. The software, which runs on an IBM-compatible PC, was developed using Borland Turbo Pascal and employs a fast Fourier transform routine to derive the CBF. Results are displayed almost as soon as a cell is identified under the microscope, and are in accordance with previous work. The technique can now be used diagnostically and for a variety of drug trials on respiratory epithelium.

Adult↗