Activity of the combination trimethoprim-sulfamethoxazole on experimental toxoplasmosis.
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Biomedical subjects
Publications and source records attributed to A Barberi.
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Two groups of animals were treated with cholera toxin respectively with 10,000 B.D. and 20,000 B.D. soon after hepatectomy. The parameters used were: the percentage of liver regeneration, mytotic activity and the liver protein content. The resulting differences between the controls and the two groups of animals treated were not statistically significant. The Authors conclude that cholera toxin does not affect the liver regeneration in the rat.
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The liver regeneration percentage, mytotic activity and protein content were used to demonstrate the effects of streptococcal toxin on regenerating rat liver. No statistically significant difference was showed between controls and toxin treated animals. Serum level of C, resulted on the contrary, considerably reduced in the animals treated with streptococcal toxin.
The infection caused by the rubella virus is a mild disease usually with no or rare complications in children and adults. On the contrary, intrauterine fetal infection may result in defects of the child, which may either be present at birth or become apparent later in life. Such a risk led to the preparation and use of active immunoprophylaxis against rubella in females of child-bearing age, in order to prevent congenital rubella. Three rubella viruses are employed to prepare the vaccine, all derived from the same viral strain. Doubts however, exist about vaccination, in particular about (1) its teratogenic potential in pregnancy; (2) the duration of protection. As a matter of fact, congenital malformations in the fetus exposed to vaccine virus through the mother have been reported in 3% of cases. As to the second point, the data on the protective immunity in time of the vaccine are very controversial. It is clear, anyhow, that protection against infection is associated not only with persistence of adequate serum levels of antibody, but also with other immunological parameters which are still unknown. These considerations, together with the observation that a relative high percentage of vaccine recipients do not respond, lead us to suggest modifications in the present scheduling of immunization against rubella.
The authors, after a review of the literature about etiology, pathogenesis, epidemiology, pathological anatomy and clinic of newborn meningitis, report a personal experience of 15 cases. The more frequent etiological agents were Gram-positive bacteria (60%) and in particular Listeria monocytogenes type 4 and Streptococcus agalactiae. Gram-negative bacteria were isolated in 40% of cases and E. coli presented the highest ratio. All patients were treated with ampicillin-CAF association intravenous for the first 3-5 days and then i.m. or oral. The survival ratio was 77% in case of Gram-positive meningitis and 83% in case of Gram-negative meningitis. Sequeles were observed only among patients with Gram-negative meningitis; it's important to remark that in these cases the etiological agent was CAF-resistant.