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Biomedical subjects

A Bartorelli

Publications and source records attributed to A Bartorelli.

At least 73 records · Page 4Linked to original sources
PubMed1978

[Direct radioimmunological determination of plasma CEA in 1704 patients].

An original technique for the direct radioimmunological measurement of plasma CEA has been prepared. Compared to the other in use, this has the advantage of a very low incidence of false positivity. 1704 patients make up the series: the percentage of positivity in 247 suffering from gastroenteric adenocarcinoma was 66.8%, in 60 with lung cancer 30%, in 243 with malignant tumours in various sites 7.4%, in 199 with chronic liver diseases 29.6% while in 598 cases of other non-neoplastic diseases it was only 2.5%. 212 patients who underwent radical surgery for gastroenteric adenocarcinoma were also followed up and the test provided early diagnosis of the clinical re-onset of the neoplastic lesion. It is considered that plasma CEA measurement represents a useful aid to the clinician althouth it cannot be employed at present to screen gastroenteric adenocarcinomas.

Adenocarcinoma↗
PubMed1977

A study of plasma CEA by a direct radioimmunoassay method in 1704 cases.

The authors have used an original method of direct radioimmunoassay of plasma CEA for testing plasma of 1704 patients affetected by various neoplastic and non-neoplastic diseases. The percentage of positive results in blood from patients with adenocarcinoma of the gastroenteric tract was 66.8%. The positivity in other non-neoplastic diseases was 2.7%, except for liver cirrhosis and other chronic hepatopathies, which showed 29.6% of positive reactions. The test should be clinically useful in the differential diagnosis of gastro-enteric carcinoma.

Adenocarcinoma↗
PubMed1976

Preliminary studies of nonvirion antigens associated with herpes simplex virus 1 and 2 (HSV1 - HSV2).

Biochemical and radioimmunological studies have indicated the presence of a nonvirion antigen associated with herpes virus. Guinea pig kidney cells were grown in culture and infected (I-cells) for 3h with herpes virus. Uninfected cells (N-cells) served as control. The cells were collected and sonicated to obtain, after centrifugation, "soluble extract" (SI, SN). The pellets were extracted with KCl (ISP, NSP). SN, SI were submitted to gel-filtration on Sephadex G-200. Extracts from I and N cells gave similar patterns. After labelling with 125I, greater resolution was obtained in a second gel-filtration with a much smaller load. ISP contained protein species not present in NSP. Polyacrylamide gel electrophoresis of peaks from SN and SI showed that SI contained some radioactive bands not found in SN. Labelled materials from SI and SN were incubated with sera from cancer patients and normal subjects. No differences in binding were seen with SN, but SI showed 14-30% more 125I binding with sera of cancer patients than with sera from normal subjects. No such difference was seen between ISP and NSP.

Animals↗