With the use of the Doppler ultrasonic catheter telemetry system, phasic left coronary blood velocity was measured in 34 conscious subjects during transvenous pacemaker insertion and right ventricular endocardial pacing. Ventricular premature depolarizations and ventricular tachycardia, occurring as consequences of pacing catheter manipulation and competitive rhythms, reduced peak coronary blood velocity by approximately one halft. These findings provide insight into the genesis of sudden death associated with pacemaker insertion, competitive or repetitive arrhythmias, and pacemaker "runaway."

Adult↗

PubMed1975

Hyperlipidemia and hepatic hyperlipogenesis in spiny mice (Acomys cahirinus) on carbohydrate diets: relationship to peripheral underresponsiveness and low insulin release.

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Adipose Tissue↗

PubMed1975

Right ventricular volume in congenital heart disease.

With use of the Frank lead system, still loop and timed vectorcardiograms were recorded in more than 5,000 patients subjected to complete right and left heart catheterization and selective coronary cineangiography. Data so obtained demonstrated clinical superiority of the vectorcardiogram over the standard 12 lead scalar electrocardiogram. Specific advantages of the vectorcardiogram include (1) recognition of undetected atrial and ventricular hypertrophy, (2) greater sensitivity in identification of myocardial infarction, and (3) superior capability for diagnosis of multiple infarctions in the presence of fascicular and bundle branch blocks. The timed biplane vectorcardiogram is as useful as any number of simultaneously recorded electrocardiographic leads for the analysis of complex arrhythmias and beat to beat changes in intraventricular conduction. Since the validity and usefulness of this technique have been established, it should become part of the routine noninvasive evaluation of patients with cardiovascular disorders.

Adolescent↗

PubMed1975

Blood velocity at mitral valve during atrial arrhythmias in man.

By means of the Doppler ultrasonic flowmeter catheter, phasic instantaneous left ventricular blood velocity was measured at the mitral valves of 184 conscious human subjects during atrial arrhythmias. Atrial extrasystoles and pacemaker-induced atrial tachycardias reduced peak mitral valve blood velocities in direct relation to shortened diastolic cycle length. Atrial fibrillation with irregular ventricular responses produced beat-to-beat alternations of peak mitral velocity, with smaller peak mitral blood velocities usually associated with shortened R-R intervals on the electrocardiogram. This report represents the first comprehensive description of instantaneous and continous phasic blood velocity at the mitral valve during atrial arrhythmias in man. It is concluded that atrial tachyarrhythmias exert an adverse influence on left ventricular filling velocities.

Adolescent↗

PubMed1974