[Accidental overdose of gentamicin].
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Biomedical subjects
Publications and source records attributed to A Criado.
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The haemodynamic effects of anaesthetic induction with i.v. etomidate have been assessed in 36 patients. The variables studied were recorded under basal conditions and 3 and 10 min after induction, before surgical stimulus. There was a reduction in cardiac output, stroke volume and arterial pressure, and a compensating increase in heart rate. Pulmonary arterial pressure and vascular resistance, central venous pressure and pulmonary capillary wedge pressure were virtually unchanged. Although etomidate has a negative inotropic effect, the variables which were depressed remained at all times within acceptable limits.
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The cardiovascular effects of equipotent concentrations of enflurane and halothane were studied and compared in two groups of patients. The agents were shown to have similar effects.
Twenty-five patients from the intensive care unit who had been subjected to tracheostomy and require mechanical respiration were studied. Data are presented concerning the bacteriological controls performed on the tracheal exudates, various parts of the ventilators (Engström Model 200 and Bennett PR-2), and the Wright spirometer. The germs found were mainly pseudomonas, enterobacteriaceae germs and bacteria from the acinetobacter group. There was a high incidence of infection in the tracheostomies of these patients. We found a cause and effect relationship between the contaminating bacteria isolated from the cannula and the bacteria isolated from the tracheal exudates in the case of pseudomonas aeruginosa. However, this was not found to be the case where enterobacteriaceae were concerned. Acinetobacter calcoaceticus were isolated almost exclusively in the ventilators. The study calls attention to the need for rigorous disinfection of ventilators to prevent hospital cross infections.
An 85-year-old man with a history of moderate chronic obstructive pulmonary disease in treatment with anticholinergic drugs was admitted to the recovery unit for postoperative monitoring after right inguinal herniorrhaphy surgery and removal of a strangulated intestinal section. On the third day after surgery the patient developed radiographic signs consistent with pneumonia and required mechanical ventilation. Two blood cultures and a respiratory secretion sample grew a microorganism identified as Hafnia alvei. H. alvei is a gram-negative bacillus that colonizes the digestive tract of humans and animals and in immunodepressed patients it can colonize the mouth and pharynx. Isolation of H. alvei is described in the literature on pediatric patients and those with a history of immune deficiency or chronic disease. Infection has a severe impact on general health. We report a rare and interesting case of pneumonia and bacteremia from H. alvei infection acquired by an immunocompetent patient soon after arrival in the postoperative recovery unit. The patient died of the infection.
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The changes in leukocyte overall and differential counts during anesthesia and surgery were evaluated in 24 patients scheduled for cardiac surgery with cardiopulmonary bypass. All the end of cardiopulmonary bypass a marked and sustained leukocytosis was found (10.2 and 11.1 x 10(9).l-1), which was significantly different from baseline values (6.7 x 10(9).l-1), the values previous to cardiopulmonary bypass (6.2 and 6.4 x 10(9).l-1, and the values 30 minutes after it (5.3 x 10(9).l-1). In the differential count there were significant increases in neutrophils, associated with band and immature forms, corresponding with significant reductions in lymphocytes. There was no significant association of leukocyte variability during and after cardiopulmonary bypass and the perfusion time, the type of oxygenator or the need for intraoperative transfusion. All the reported changes tended to become normal during the first postoperative days.
The changes in the number of platelets during anesthesia and operation were evaluated in 24 patients (8 females and 16 males) scheduled for cardiac surgery with cardiopulmonary bypass. There was a significant (p less than 0.05) thrombopenia at the beginning of perfusion, which persisted 60 minutes after the end of cardiopulmonary bypass. There were no significant differences when these changes were evaluated depending on the type of oxygenator, the need for transfusion or the duration of cardiopulmonary bypass. There was a reduction in the platelet count at the beginning of the bypass (207 to 124 x 10(9).1(-1), when blood contacts with the synthetic surfaces of the circuits and the oxygenator, al though-the most marked reduction was found at the end of bypass (95.9 x 10(9).1-1), coinciding with protamine administration. The function and number of platelets tended to become normal in the first hours of the postoperative period.
We report the use of left ventricular assistance with a centrifugal pump in a patient with refractory left ventricular failure after aortic valve replacement. Assistance was maintained during the first 24 hours until the hemodynamic status allowed its withdrawal. The used flows ranged from 1.5 to 5 l/min, and there were no complications except hemorrhage (95 ml in 3 hours) that could be stopped without reoperation.