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Biomedical subjects

A D Govan

Publications and source records attributed to A D Govan.

At least 19 recordsLinked to original sources
PubMed1988

Malignant lymphoma presenting as an ovarian tumour: a clinicopathological analysis of 34 cases.

The clinicopathological features of 34 patients with malignant lymphoma or leukaemia where the initial presentation was as an ovarian tumour are described. Nineteen patients died, usually within 1 year of diagnosis, whilst 15 survived, some for long periods. Factors indicating a poor prognosis were rapid onset of abdominal symptoms, the presence of systemic symptoms, bilateral ovarian tumours, advanced stage and a histological pattern other than that of a B-cell lymphoma. For staging purposes the Ann Arbor method appeared a more sensitive prognostic indicator than did the FIGO staging system. It is suggested that primary malignant lymphomas of the ovary are extremely rare and that for therapeutic purposes all lymphomas of the ovary should be regarded as local manifestations of systemic disease.

Acute Disease↗
PubMed1987

Human antibodies to ovarian cancer antigens secreted by lymphoblastoid cell lines.

Human antibodies, showing specificity for ovarian cancer, have been produced following Epstein-Barr virus transformation of lymphocytes from involved lymph nodes. Specificity was assessed initially using established ovarian cancer and other cell lines and then confirmed by histological examination, employing immunofluorescent staining of tumour tissue. The lymphocytes have been in continuous culture for more than 9 months and secrete IgG antibodies at a rate of 0.5-5 micrograms/ml/10(6) cells/5 days.

Antibodies, Neoplasm↗
PubMed1985

A role for amniotic epithelium in control of human parturition.

A peroxidase anti-peroxidase staining technique was used to determine the presence of pregnancy-associated prostaglandin synthetase inhibitor (PAPSI) in human amniotic epithelium from 20 pregnant women at 36-40 weeks' gestation. PAPSI was present in amniotic epithelial cells in 12 of 15 women before the onset of labour. No PAPSI was found in amniotic epithelium from 5 women in clinically established labour. These findings indicate that the amnion is a source of this endogenous prostaglandin synthetase inhibitor and suggest a local role for amniotic epithelium in initiating labour at term.

Amniotic Fluid↗
PubMed1981

Sertoli-Leydig cell tumors: a clinicopathologic study of 34 cases.

Thirty-four cases of Sertoli-Leydig cell tumor were studied. All tumors were limited to the ovary at the time of initial surgery. Eight tumors were well differentiated, 15 were of intermediate differentiation, and 11 were poorly differentiated. Six cases contained heterologous elements. The less differentiated tumors occurred in patients with a lower median age and were more likely to produce androgenic manifestations. Follow-up of one year or longer was obtained in 15 patients, with an average follow-up in these patients of 6.1 years. Only one patient, who had a poorly differentiated tumor, died of the neoplasm in this series. Although follow-up was limited in this study, our findings suggest that the better differentiated tumors have a relatively favorable prognosis. This neoplasm is composed of sex-cord and stromal elements, and its components have the capacity to a greater or lesser extent to recapitulate the cells of the testis at different stages of development.

Adolescent↗
PubMed1981

Yolk sac and allied tumours of the ovary.

A review is presented of the histological appearances of 38 yolk sac tumours of the ovary and four so-called embryonal carcinomas together with the associated clinical features. It is suggested that these neoplasms belong to a single taxonomic group of embryonal ovarian tumours differing only in the concomitant types of differentiation. One yolk sac tumour occurred in an individual of 46 XY chromosome constitution and another in a patient with a gonadoblastoma in the contralateral ovary. The value of post-operative serial assays of serum AFP is stressed.

Adolescent↗
PubMed1980

Ovarian sex cord tumours with annular tubules.

Five cases of ovarian sex cord tumours with annular tubules are presented. The ages of the patients ranged from 8 to 45 years and the size of the tumours varied from 1 to over 18 cm in diameter. All patients presented with evidence of hormonal disturbance and two appeared to have excess gonadotrophin production. The Peutz-Jeghers syndrome was not described in any patient. The possible origin of the tumour is discussed.

Adult↗
PubMed1979

A report of the histological features in 12 cases of gonadoblastoma.

This report deals with 12 cases of gonadoblastoma submitted to the Ovarian Tumour Panel of the Royal College of Obstetricians and Gynaecologists. These tumours are found in children and young adults. Children may present with obvious genital malformation, retarded growth or precocious puberty. In adults the main compliant is amenorrhoea but sometimes there is associated masculinization. Histologically the gonadoblastoma has a distinctive structure, easily recognized in most instances. The most important feature is the instability of the germ cells in these tumours. Nine of these cases showed an associated dysgerminoma, bilateral in 4. In any cases of suspected gonadal dysgenesis presumptive evidence of diagnosis is suggested by the presence of a Y chromosome, raised gonadotrophin output and pelvic calcification on X-ray examination. At operation, streak tissue on both sides must be removed since these tumours are frequently microscopic in size. For the same reason the tissue removed should be serially sectioned.

Adolescent↗
PubMed1976

The histology of eclamptic lesions.

A brief description is given of the main lesion found in eclampsia. Emphasis is placed on the marked difference between the type of lesion found in the kidney and those found in other organs. It is suggested that they may be explained on the basis of increased coagulability of the blood, hypertension and possibly increased permeability of blood vessels. Hypertension may damage vessels and determine the sites of thrombus deposition. Increased permeabilithe mesangium of the glomerulus.

Adrenal Glands↗
PubMed1975

Ovarian morphology in oligomenorrhea.

An account is given of the ovarian histology on 38 patients complaining of oligomenorrhea. The majority of these patients, 22, had polycystic ovaries, but in 11 the ovaries were comparatively normal in appearance. In another 3 they were small and inactive. The remaining 2 cases had chromosomal anomalies. The polycystic ovaries could be divided into two groups, one showing little follicular activity, the other a great deal. The maturation of most follicles in all ovaries appeared to be restricted and antral follicles rarely grew beyond a diameter of 4-5 mm. It is suggested that this degree of maturation is related to a low tonic secretion of FSH. An excessive production of luteinized thecal cells was found around most antral follicles. Polycystic change in these ovaries is mainly due to the presence of many atretic follicles. Luteinized thecal cells persist after atresia and it is suggested that this may be the result of a tonic secretion of LH. The lack of preantral and antral follicles in one group of polycystic ovaries may indicate a prolongation of the atretic process. Ovulation occurs with considerable frequency in these women. The mechanism is obscure.

Biopsy↗
PubMed1975

An evaluation of human placental lactogen levels in hypertension of pregnancy.

Maternal plasma levels of human placental lactogen (HPL) are decreased in hypertensive pregnancies and the concentration is related to the severity of the condition. Of infants who had HPL concentrations in the fetal danger zone (more than 2 SD's below normal mean) 75 per cent developed fetal distress, neonatal asphyxia or were light for dates. Patients who are identified in this way have lighter infants and placentae than their unidentified counterparts with normal HPL levels.

Asphyxia Neonatorum↗