Biomedical subjects
Publications and source records attributed to A D Govan.
Twenty patients with primary amenorrhoea have been investigated by laparoscopy and gonadal biopsy, endocrine and chromosomal studies. Laparoscopy and gonadal biopsy made the major contribution to the diagnosis, prognosis, and management of the patients and provided a method for study of the functional anatomy of the ovary.
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Fifteen cases of aberrant polypoidal glandular hyperplasia of the cervix are described. The lesion was found in five pregnant patients. The remaining 10 patients had taken contraceptive pills over a considerable period of time. The lesion while histologically bizarre is benign, the changes being to a great extent cytoplasmic and not nuclear. It is suggested that it is formed by the influence of steroids on a cervix which is already pathological. It is further suggested that two changes are essential before steroids can have this effect. Polypoidal lesions must already be present and must exhibit reserve cell hyperplasia.
ABNORMALITIES OF THE CERVICAL EPITHELIUM ARE SET OUT IN TWO MAIN GROUPS: bland lesions which are regarded as unrelated to malignancy, and malign lesions which are considered as potential precursors of invasive carcinoma. The histological features of each condition and the cytological pattern of the corresponding cervical smear are described and correlated. Cone biopsy is advocated as the only satisfactory form of cervical biopsy for both the diagnosis and evaluation of lesions such as dysplasia and carcinoma in situ. It is emphasized that further study is necessary to determine their natural history and prognosis in relation to invasive carcinoma.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.