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Biomedical subjects

A Datry

Publications and source records attributed to A Datry.

At least 73 records · Page 4Linked to original sources
PubMed1982

[Treatment of urinary and intestinal bilharziosis with praziquantel. Apropos of 182 cases].

182 patients representing 188 cases of schistosomiasis (including 152 S. haematobium, 34 S. mansoni, and 2 S. intercalatum cases) were treated with praziquantel using 40 mg/kg in a single intake. Biological check-up did not reveal any abnormality that could have been related to the treatment. Clinical side-effects appeared in 25% cases and were essentially gastrointestinal symptoms, headaches, dizziness. Efficiency was assessed by direct parasitological examinations of the feces or urine that were performed after treatment. It reached 91% for S. haematobium and 95% for S. mansoni schistosomiasis.

Adolescent↗
PubMed1981

[Dracunculus medinensis infestation following holidays in West Africa. Epidemiological implications (author's transl)].

All 50 patients with dracunculiasis admitted to a Paris hospital during a 3-year period were West African immigrant workers, 70% of whom came from a very limited geographical area. Only 6 of the workers were "first arrival"; the others had contracted filariasis during holidays in their home country. The mean duration of stay in hospital was 40 days. In 40 of the patients who had spent 6 months or less in their home country, the exact dates of first arrival in France, departure to, and return from, Africa and emergence of adult worms were available, so that the duration of the Dracunculus medinensis cycle (mean: 12 +/- 1,7 months) and the period of local transmission could be determined. These epidemiological data account for the seasonal character of infestation and for the occurrence of dracunculiasis in France. They also exclude a diagnosis of filariasis based on more or less suggestive symptoms when the delays after possible infestation are either too long or too short.

Adult↗
PubMedDate not supplied

Treatment of Strongyloides stercoralis infection with ivermectin compared with albendazole: results of an open study of 60 cases.

Ivermectin is highly effective against animal intestinal nematodes and is used in the treatment of onchocerciasis in humans. A study was undertaken to compare the efficacy of the drug with that of albendazole in the treatment of uncomplicated strongyloidiasis. Sixty patients with confirmed Strongyloides stercoralis infection were enrolled in an open randomized study and given either albendazole, 400 mg/d for 3 d or ivermectin, 150-200 micrograms/kg in a single dose. Efficacy and tolerance were evaluated on days 7, 30 and 90. Each visit included a parasitological examination of 3 stool specimens, using saline and Kato smears and formalin-ether and Baermann concentrations. Fifty-three patients were eligible for evaluation. Parasitological cure was obtained in 24 of the 29 patients treated with ivermectin (83%) and in 9 of the 24 patients who were given albendazole (38%); ivermectin was significantly more effective than albendazole (P < 0.01). Clinical and biological adverse reactions were negligible in both treatment groups. The 20 patients who failed therapy were given a second treatment course with 150-200 micrograms/kg of ivermectin in a single dose or on 2 consecutive days. Sixteen patients were cured and the other 4 had only incomplete follow-up. Ivermectin therefore constitutes an acceptable therapeutic alternative for uncomplicated strongyloidiasis.

Adolescent↗
PubMedDate not supplied

[Effect of the use of drinking water on the pathogenic fecal flora in a Sahel rural region].

Within the scope of a village hydraulic programme, in a Sahel rural area, an investigation was conducted in a school to determine the effect of the use of drinking water on fecal flora. One year following the installation of a hydraulic pump, it was observed that pathogenic salmonellae, shigellae and amoebic cysts had virtually disappeared. In contrast, the perennial character of viral contamination was demonstrated. Water guaranteed potable, therefore, appears to be an essential factor in the prevention of infections due to fecal pathogenic microorganisms. It is essential, however, that the areas surrounding the pumps be subjected to strict supervision to avoid pollution of the underground water sheet.

Adenoviridae↗
PubMedDate not supplied

[Human cryptosporidiosis: a propos of 4 cases].

Cryptosporidiae are ubiquitous protozoan belonging to the coccidiae family which parasite many wild and domestic animals bowels. Man gets infested by ingestion oocysts. The parasite complete cycle takes place on the surface of intestinal epithelial cells microvillosities. Human cases that we described occurred among patients presenting (or not) with acquired or congenital immunity depression. Diarrhea is the main symptom. Diagnosis is based on parasitological stool examination and pathological study of intestinal biopsies. At the present time no specific treatment is known and only the immunity deficit correction can possibly cure cryptosporidiosis.

Adult↗
PubMedDate not supplied

[Curative treatment of malaria Plasmodium falciparum, P. vivax and P. ovale malaria with mefloquine].

Mefloquine (WR 142-490, RO 21.5998), and antimalarial 4-quinoleine-methanol, active on multiresistant strains of P. falciparum is a resourceful product because of its pharmacocinetics and the possibility it opens of a single day curative therapy. Its mean half-live is 15 days, with important individual variations from 8 to 23 days as well as racial one within North-American, Asiatic or African patients. A 1,25 to 1,50 g dose divided in 2 or 3 intakes during 16 hours has proved to be effective in 34 P. falciparum cases. Lower doses, near 1 g seem sufficient for P. vivax (6 cases) and P. ovale fits (4 cases). Clinical and biological acceptance are good, according to this limited study. The use of mefloquine might nowadays be reserved for geographical areas where resistance to P. falciparum is significantly high. Its diffusion in Africa, south of the Sahara, though conceivable, might be discarded for the time beeing.

Adolescent↗