Pseudo-tumorous form of radiation-induced subacute cerebral necrosis resolved with tetracosactide.
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Biomedical subjects
Publications and source records attributed to A Destee.
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Two personal cases and a review of the literature permit to distinguish by anatomical, clinical and paraclinical aspects : neurilemmoma of the jugular foramen (type III), neurilemmoma of the bulbar spinal (type I), and of the medullary spinal (type II). This classification permits to choice surgical approach.
With reference to three cases the main features of subdural empyema are recalled. These collected suppurations are often secondary to frontal or maxillary sinusitis due to a streptococcus. Clinical features are those of meningo-encephalitis but signs of cortical damage are more prevalent. Many cases of subdural empyema which would have been unrecognized by conventional procedures are now diagnosed by CT scan. CT scan has also improved monitoring; thus, two of the three patients could be given medical treatment alone. The authors believe that non-surgical treatment would ensure recovery in many cases of subdural empyema. Surgery should be restricted to patients with severe intracranial hypertension or persistence of a large mass after several weeks of antibiotic treatment. Non-surgical treatment may improve prognosis.
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The analysis of 8 cases of rheumatoid arthritis involving the cervical spine and resulting in neurological complications leads the authors to change their therapeutic approach. After a study of etiopathological aspects they advocate wider indications of surgical treatment. Clinical and radiological criteria are defined and operative risks are described.
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The semeiology of 72 tumors of the pineal area seen between 1949 and 1982 is analyzed. Manifestations, which are polymorphic and often misleading at onset, subsequently become manifold. Though a given syndrome may result from the mingling of several factors it is possible to establish a correlation between clinical findings and anatomical lesions. Conversely, histo-clinical correlations, which are requisite to institute specific therapy, are still as difficult to ascertain. Stereotaxic biopsy is therefore needed before planning therapy.
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A new surgical technique for the treatment of cerebral ischemia is reported. A scalp artery is freed and placed in contact with the cerebral cortex after craniotomy and opening of the dura mater. Thirty such operations have been performed over a period of 2 years. An analysis of the results, advantages and disadvantages, and indications for this type of surgery is given.
Chronic subdural haematomas are frequently seen in neurosurgical practice, but because of the multitude of their clinical presentations, appropriate diagnosis is often not made in the early stages. The cases reported concern a 62-year-old male and a 54-year-old woman, both presenting in an unusual manner, namely a progressive quadriparesis.
The methionine-enkephalin analog FK 33-824 was administered intravenously to 12 patients with Huntington's disease in a crossover double-blind study. The abnormal involuntary movements (AIM) were not improved after administration of 0.5 mg of FK 33-824. A significant decrease in the AIM score was observed only 150 and 180 min after injection of high doses (2 mg); however, the difference between the active drug and the placebo was never statistically significant. These results are discussed in terms of experimental data suggesting a relationship between methionine-enkephalin and dopamine neurons in the brain and of methionine-enkephalin deficiency in the brain of patients with Huntington's disease.
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Three adults presented convulsive fits for the first time in their lives, and examination with a CT scan showed no anomalies. Repetition of the CT scans a few weeks later revealed the presence of evolving lesions. Based on these 3 cases and 11 previously published cases, the problem of "normal" CT scans and rapidly developing glioblastomas is discussed.
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