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Biomedical subjects

A E Nilson

Publications and source records attributed to A E Nilson.

At least 37 records · Page 2Linked to original sources
PubMed1984

Angiographically discovered, non-operated renal artery aneurysms.

Angiographies (a total of approximately 9 500) and patient records revealed 56 patients with renal artery aneurysm during the period 1960 to 1974. Fifteen patients were operated upon electively and 3 were lost for follow-up. Rupture occurred in four leading to acute nephrectomy. Thus, 34 patients were left for studies on the natural course. They were 29-82 years old (mean 58 years) at diagnosis and were followed for at least 90 months. Twelve were males and 22 females. The aneurysms had a diameter of 3-25 mm (mean 12 mm), were fusiform in 7 and saccular in 27 cases; 9 were calcified. Repeated angiographies were carried out in 7 patients at intervals of up to 73 months showing slight enlargement of one aneurysm, disappearance of another and no change in 5. Sixteen patients were alive at the end of the follow-up period 90-220 months (mean 157 months) after the first or only angiography. Eighteen patients died after 2-204 months (mean 84 months), 14 of cardiovascular disease unrelated to the renal arteries, 3 of malignant tumour and one of pancreatitis. Autopsy in 12 patients did not show rupture of any renal artery aneurysm. Thus, in a considerable number of patients the disorder was uncomplicated and compatible with a long life.

Adult↗
PubMed1984

The structure-function relationship of I-A molecules: correlation of serologic and functional phenotypes of four I-Ak mutant cell lines.

We have isolated and characterized four mutant I-Ak-expressing cell lines derived from the B cell-B lymphoma hybrid antigen-presenting cell line TA3. The mutants were isolated by first selecting against expression of one Ak epitope by treatment with a monoclonal antibody in the presence of complement and then selecting for retention of a second Ak epitope by electronic cell-sorting of cells stained for fluorescence with a second monoclonal antibody. The serologic and functional phenotypes of the mutants were characterized by using panels of I-Ak-specific monoclonal antibodies and I-Ak-restricted T hybridomas. We obtained one Ak alpha mutant (J4) that no longer reacts with any Ak alpha-specific antibody and also is incapable of stimulating any I-Ak-restricted T hybridoma. We obtained three Ak beta mutants (LD3, K5, G1) that express a wide range of serologic and functional phenotypes. Correlation of the serologic and functional phenotypes reveals that the serologic epitope Ia.1 may overlap with a major site of T cell recognition, whereas the Ia.17 serologic epitope appears to be only a minor site for T cell recognition.

Animals↗
PubMed1983

Autologous renal transplantation and pyelocystostomy after unsuccessful pyeloplasty.

A total of 4 patients with persistent outflow obstruction after pyeloplasty for hydronephrosis was reoperated with renal autotransplantation and pyelocystostomy. All 4 patients had undergone an unsuccessful Anderson-Hynes pyeloplasty and 2 also had had a second operation. All patients had relief of pain, normalization of urine outflow and improved renal function during an observation of 27 to 37 months. Occasional asymptomatic bacteriuria occurred in 2 patients. Thus, renal autotransplantation and pyelocystostomy may be considered a useful and safe method to eliminate persistent outflow obstruction after unsuccessful pyeloplasty.

Adult↗
PubMed1983

Autologous renal transplantation with direct pyelocystostomy in the treatment of recurrent renal calculi.

Six male patients with severe recurrent urinary calculus disease underwent renal autotransplantation with direct pyelocystostomy to allow spontaneous passage of stones. The only serious complication was an early renal vascular thrombosis with graft loss in one patient who had been operated on three times before with ipsilateral partial resections for nephrolithiasis. The other five patients did well (observation time 4-34 months). Their renal function has remained unchanged. Autotransplantation with direct pyelocystostomy should be considered in patients with multiple recurrent stones of the upper urinary tract, especially when some degree of obstruction has developed or when other predisposing anomalies prevail.

Adult↗
PubMed1983

Fibroepithelial polyp of the ureter.

Three patients with fibroepithelial polyp of the ureter are described with respect to clinical, radiographic and morphological characteristics. The importance and possibilities to reach at a correct preoperative diagnosis to allow conservative surgical treatment is stressed.

Adult↗
PubMed1982

Urinary diversion via a continent ileal reservoir: clinical results in 12 patients.

Urinary diversion via a continent ileal reservoir has been performed in 12 patients. An isolated ileal reservoir was constructed using the technique described for patients with a continent ileostomy. The ureters were implanted into an afferent segment provided with a reflux-preventing nipple valve. There were few operative complications and no operative mortality. Late complications involving malfunction of the nipple valves occurred in 8 patients and were corrected surgically. Postoperative followup presently is between 9 months and 6 1/2 years. Two patients have died: 1 in an accident and 1 of metastatic bladder carcinoma. The remaining 10 patients are continent and without reflux to the upper urinary tract. The reservoir generally is emptied by intermittent self-catheterization between 3 to 6 times daily. The volume capacity of the reservoir is more than 500 ml. Urinary cultures have been constantly negative in 7 patients and the contents of the reservoir more or less permanently contained bacteria in 5. Dilatation of the upper urinary tracts, progressive renal deterioration or metabolic disturbances have not been encountered. All patients are satisfied with this type of urinary diversion, especially those who have undergone other types of diversion previously.

Adult↗
PubMed1982

Uretero-neocystostomy in the treatment of postoperative uretero-vaginal fistula.

Nine patients with unilateral uretero-vaginal fistula afer hysterectomy were seen over a 9-year period. In 5 patients radical pelvic surgery combined with radiotherapy had been carried out because of carcinoma of the cervix. In one patient the fistula developed following total hysterectomy 18 years after radiotherapy because of a cervical carcinoma. In 3 patients hysterectomy had been performed for benign disease, uterine fibroids or fibroids combined with endometriosis. In one patient the fistula was successfully treated with an indwelling ureteral catheter for 7 days. In the other 8 patients uretero-neocystostomy was successful as regards vaginal urine leakage; following this procedure one kidney was lost in the follow-up period. It is concluded that in patients with uretero-vaginal fistula, uretero-neocystostomy can be performed with satisfactory results even when the patient has been treated for a cervical carcinoma by radiotherapy and radical surgery.

Adult↗
PubMed1981

Hypotonic duodenography and secretin-CCK test in the diagnosis of pancreatic disease.

Sixty-five patients with possible pancreatic disease or long-lasting upper abdominal symptoms were examined by means of the secretin-CCK test and hypotonic duodenography. Both examinations were performed after one duodenal intubation. In patients with pancreatitis functional abnormalities were revealed in 85 per cent while the duodenography was abnormal in 43 per cent. In patients with carcinoma, 77 per cent had abnormal exocrine pancreas function and 70 per cent had abnormalities demonstrated at duodenography. The value of the two examinations for assessment of patients with upper abdominal symptoms and pancreatic disease is discussed.

Adult↗
PubMed1981

Hypotonic duodenography and endoscopic retrograde pancreatography in the diagnosis of pancreatic disease.

Hypotonic duodenography and endoscopic retrograde pancreatography were performed in 45 non-icteric patients with suggested pancreatic disease or long-standing upper gastrointestinal symptoms. The accuracy of each method in the diagnosis of pancreatic disease was compared. Hypotonic duodenography revealed pancreatitis in 48 per cent and ERP in 83 per cent of the cases. All 6 pancreatic tumours were detected at ERP and 3 at duodenography. The role of hypotonic duodenography and endoscopic retrograde pancreatography in the diagnosis of pancreatic disease is discussed.

Adult↗
PubMed1981

Thigh adductor contraction during transurethral resection of bladder tumours: evaluation of inactive electrode placement and obturator nerve topography.

Thigh adductor contraction occurred in 17 of 160 patients during transurethral resection of newly diagnosed bladder tumours. In 13 of the 17 patients contractions were abolished by changing the site of the inactive electrode from the buttocks to the thigh. The topographic relationship between the obturator nerve and the bladder wall studied radiographically and at autopsy showed that the distance between the bladder and the nerve considerably diminished with increasing bladder volume. Thus, when obturator nerve stimulation occurs during transurethral resection transposition of the inactive electrode from the buttocks to the thigh should be tried first to prevent further stimulation. Moreover, TUR at low bladder volume may reduce the frequency of obturator nerve stimulation.

Electrodes↗