PubMed Health⌕ Search

Biomedical subjects

A E Radzevich

Publications and source records attributed to A E Radzevich.

At least 19 recordsLinked to original sources
PubMed2006

[The specific features of coronary heart disease in patients with pulmonary tuberculosis].

The prevalence and some specific features of coronary heart disease (CHD) were studied in patients with pulmonary tuberculosis. Its prevalence was determined in relation to age, gender, and the type of a tuberculous process. ECG changes in ST segment and T wave were found in patients with pulmonary tuberculosis without concomitant CHD under intoxication. The diagnosis of CHD was established in 41 of 491 patients, which was 8.4%. CHD was more common in elderly and senile females. The clinical manifestation of CHD was observed in females of older age than in males; under the age of 60 years, the prevalence of CHD is less among the patients with pulmonary tuberculosis and above the age of 60 years, it does not differ from that in the general population. CHD most commonly manifests clinical signs in patients with residual changes after experienced pulmonary tuberculosis and in cirrhotic tuberculosis, i.e. when the tuberculosis process is less active.

Adult↗
PubMed2005

[Use of alpha-tocopherol acetate in the treatment of hemodynamic disorders in patients with pulmonary tuberculosis].

Examination of 101 patients with pulmonary tuberculosis established the impact of specific intoxication on central hemodynamics in 51 patients. Specific treatment was found to have a certain positive effect on impaired hemodynamics. However, there were no significant changes in patients with severe tuberculosis. Hemodynamics substantially improved when alpha-tocopherol acetate was supplemented to antibacterial therapy.

Adult↗
PubMed2005

[Use of preductal in therapy of hemodynamic complications in patients with tuberculosis].

To treat hemodynamic disorders, preductal was used in combination with antibacterial therapy in 30 patients with disseminated destructive pulmonary tuberculosis for a month. A control group comprising 31 patients was in parallel observed. Clinical, electrocardiographic, and echocardiographic studies were performed to evaluate the efficacy of preductal. The drug was found to promote improvements in left ventricular function and central hemodynamics as a decrease in end-systolic volume and increases in ejection fraction and stroke and minute volumes. Preductal exerted no significant effect on right ventricular dysfunction associated with chronic cor pulmonale.

Adult↗
PubMed2004

[Nebivolol in the treatment of ischemic heart disease patients with chronic heart failure].

AIM: To assess effectiveness of inclusion of nebivolol in complex therapy of patients with chronic heart failure (CHF) due to ischemic heart disease (IHD). MATERIAL: Patients (n=62, age 47-73 years) with NYHA class II-III CHF and left ventricular (LV) ejection fraction (EF) less than 45% receiving standard therapy +/- nebivolol (5 mg/day). The patients were followed up for 4 months. RESULTS: After 4 months improvement of clinical state, exercise tolerance, parameters of central hemodynamics and LV remodeling, lipid spectrum, rheological properties of blood and platelets haemostasis was more pronounced in a group of nebivolol treated patients. CONCLUSION: Inclusion of nebivolol in complex therapy increases efficacy of treatment of patients with CHF due to IHD.

Adrenergic beta-Antagonists↗
PubMed2004

[Lisinopril effects on cerebral blood flow and blood rheology in hypertensive patients].

AIM: To access the effect of lisinopril (diroton) on cerebral circulation and blood rheology in patients with arterial hypertension stage II. MATERIAL AND METHODS: The trial included 37 patients (16 males, 21 females) with a mean arterial hypertension (AH) history 15.9 +/- 5.6 years. Diroton was given in a dose 10-40 mg/day for 6 months. Cerebral circulation (total cerebral circulation and venous outflow--TCC and VOF) was accessed by means of doppler ultrasonography. Blood and plasm rheology was determined using a rotational viscozymeter ACP-2. Instrumental tests were performed at baseline and at the end of the study. RESULTS: Rheology tests showed that diroton-treated patients achieved a significant decrease in blood viscosity in high, moderate and low shear stress and plasma viscosity, a decrease in platelet aggregation index and an increase in the index of erythrocytic deformability. All these changes were accompanied with a significant fall in fibrinogen and hematocrit. Doppler ultrasound revealed an insignificant increase in TCC and VOF. CONCLUSION: Diroton significantly improved impaired blood rheology and viscosity in AH patients as well as cerebral hemodynamics in patients with subnormal cerebral circulation and venous outflow at baseline.

Adult↗
PubMed2003

[The state of hemodynamics and microcirculation in patients with hypertensive disease during long term controlled therapy with lisinopril].

Lisinopril (Diroton, 10-40 mg/day) was given for 6 months to 30 patients (mean age 57.2+/-0.64 years) with stage II hypertension (WHO, 1999). Left ventricular diastolic function and microcirculation were assessed by echocardiography and biomicroscopy, respectively. Treatment with lisinopril was associated with improvements of impaired left ventricular diastolic function, structural and functional state of the heart. Parameters of microcirculatory vascular bed also improved.

Adult↗
PubMed2002

[Respiratory and renal functions and blood electrolytic composition in patients with pulmonary tuberculosis in the treatment of heart failure].

The authors studied respiratory and renal functions and blood electrolytic composition in 94 patients with pulmonary tuberculosis in the treatment of heart failure with angiotensin-converting enzyme inhibitors (ACEI) and an angiotensin II blocker (AIIB). At the same time they examined a control group of 24 patients untreated with ACEI and AIIB. All the patients received combined antituberculous therapy. Cardiac glycosides and diuctics were given in some cases. During 1-2 months, the patients from the experimental group additionally took captopril, 12.5-25.0 mg, twice a day or prestarium, 2.0-4.0 mg, once a day, or cossar, 50 mg, once a day. After the treatment, ACEI and AIIB were found to have no effect on blood gas and electrolyte composition, and respiratory and renal functions. With captopril and ramipril there was a higher patency of minor bronchi in the experimental groups than in the controls.

Adult↗
PubMed2002

[Effect of eprosartan on left ventricular diastolic function and cerebral hemodynamics in patients with hypertension].

Eprosartan (600-1200 mg/day) was given for 4 weeks to 28 patients aged 32-62 years with stage II-III hypertension (WHO, 1999). Left ventricular diastolic function and cerebral blood flow were assessed by echocardiography and ultrasound dopplerography. Treatment with eprosartan was associated with improvements of impaired left ventricular diastolic function, structural and functional state of the heart, venous outflow from cerebral vessels, and restoration of unpaired autoregulation of cerebral blood flow. All these phenomena could potentially lead to normalization of cerebral tissue perfusion and stabilization of cerebral blood flow.

Acrylates↗
PubMed2001

[Activity of the renin-angiotensin-aldosterone system and its impact on the effectiveness of treatment of chronic heart failure in patients with pulmonary tuberculosis].

The renin-angiotension-aldosterone system (RAAS) was studied in 93 patients with pulmonary tuberculosis complicated by chronic heart failure (CHF). Radioimmunoassay was used to determine plasma renin activity (PRA) and serum angiotensin I and aldesterone levels. There was higher RAAS activity, as shown by elevated PRA. RAAS activity decreased during CHF treatment with angiotension-converting enzyme inhibitors (captopril, ramipril, prestarium) and an angiotensin II-receptor blocker (cosaar), which is indicative of the efficiency of CHF treatment.

Aldosterone↗
PubMed2001

[Effects of angiotensin-converting enzyme inhibitors and cosaar on quality of life of patients with pulmonary tuberculosis and chronic heart failure].

Two and thirty four patients with pulmonary tuberculosis complicated with chronic heart failure (CHF) were examined to study life quality (LQ) and its changes due to hemodynamic correction. LQ was assessed by the Minnesota Life Heart Failure Quality questionnaire filled in by patients before and after treatment of CHF with angiotensin-converting enzyme inhibitors (captopril, ramipril, prestarium) and an angiotensin II-receptor blocker (cosaar) given for 1.5-2 months during chemotherapy for tuberculosis. In patients with pulmonary tuberculosis complicated by CHF, LQ was found to be related to the degree of hemodynamic disorders and to significantly improves with complex treatment of a tuberculous process and with correction of hemodynamic disorders.

Angiotensin II↗
PubMed1999

[Ramipril treatment of heart failure in disseminated forms of pulmonary tuberculosis].

A total of 108 patients with heart failure-complicated disseminated pulmonary tuberculosis were followed up. Fifty eight patients received combined therapy including the angiotensin-converting enzyme inhibitor ramipril in a daily dose of 0.25-0.50 mg for 1.5-2 months. Fifty ramipril-untreated patients comprised a control group. Examinations revealed the benefits of the agent in decompensatory chronic cor pulmonale as improved right ventricular systolic and diastolic functions and health in the patients.

Aged↗
PubMed1997

[A quantitative assessment of the blood supply to the head by indirect rheography].

Clinical-experimental basis of the possibility of application of the method of indirect rheography of head (IRH) in wide clinical practice was presented. Estimation of the results reproduction and accuracy of the method was performed too. 40 healthy individuals of both sexes at the age of 18-50 and 102 patients with spinal osteochondrosis, arterial hypertension and neurocirculatory dystonia were examined. It was determined that IRH provided 93% of results reproduction and its precision was 90% and higher in comparison with ultrasound method. It was established that head circulation was 750-1200 ml/min or 12-24% of cardiac output in healthy individuals. The results of the study of head blood circulation in some groups of patients were also discussed.

Adolescent↗
PubMed1997

[Sotahexal pharmacodynamics in patients with ischemic heart disease].

Therapeutic and prophylactic antiarrhythmic efficacy of sotalol hydrochloride (Sotahexal, "Hexal", Germany) and its effects in intracardiac hemodynamics and ECG parameters were evaluated in 95 patients with ischemic heart disease (IHD). The highest response to the drug was observed in ventricular extrasystoles, arterial flutter and fibrillation. Acute episodes of arrhythmia are managed by bolus administration of Sotahexal [correction of Hexal]. In this case greater risk of side effects exists. It is desirable to decide on the drug dose, mode of administration on the individual basis with due consideration of the risks and dangers which could be avoided in case of adequate instrumental control.

Adrenergic beta-Antagonists↗
PubMed1993

[Prognostic significance of baseline state of platelet aggregation and blood viscosity during gravitational plasmapheresis in patients with angina pectoris].

The study was undertaken to examine 56 patients (mean age 54.9 +/- 1.1 years) who had functional class III (n = 12), IV (n = 32), and unstable (n = 12) angina pectoris. Due to inefficacy of conservative therapy, all the patients underwent gravitation plasmapheresis (GPA). The parameters of induced platelet aggregation were examined by the Born-O'Brien method and blood viscosity on a rotor viscometer before, immediately and on days 1 and 3 after GPA. It was found that the baseline blood viscosity and platelet aggregation should be known to predict the natural history of angina in the following 1-3 days after GPA. There was a pronounced positive clinical effect in higher blood viscosity and platelet aggregation. An improvement in the clinical course of the disease and its stabilization were not observed in the baseline lower blood viscosity and platelet in patients with progressive angina.

Adult↗
PubMed1989

[State of the blood platelet link of hemostasis and microcirculation in patients with ischemic heart disease during plasmapheresis treatment].

The paper provides the results of studies into plasmapheresis-induced changes in the thrombocytic link of hemostasis and microcirculation in 40 patients with coronary heart disease (CHD). Repeated sessions of plasmapheresis (P) were found to produce an inhibitory effect on platelet aggregation and to improve microcirculation in CHD patients with signs of increased platelet functional activity. In CHD patients with low platelet functional activity, the first P session was demonstrated to cause an increase in platelet functional activity whereas the subsequent sessions inhibited platelet aggregation. No significant microcirculatory improvement was seen in this group of patients. Heparin and rheopolyglucin given to control patients exerted no substantial effect on the thrombocytic link of hemostasis and microcirculation.

Adult↗
PubMed1987

[Effect of gravitation plasmapheresis on central hemodynamics and indices of myocardial metabolism in patients with acute complicated myocardial infarct].

A study of 32 patients with complicated acute myocardial infarction, treated with gravitation plasmapheresis during the acute phase of the disease, demonstrated a significant drop in blood concentrations of compounds with high molecular weights (fibrinogen, cholesterol, triglycerides, total protein) as well as a significant activation of the heart's pumping function, while total peripheral resistance declined, as did the degree of myocardial ischemia. This is interpreted as an evidence of positive effect of plasmapheresis on central hemodynamics, myocardial metabolism and clinical course of myocardial infarction in such patients.

Aged↗