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Biomedical subjects

A F Leshchinskiĭ

Publications and source records attributed to A F Leshchinskiĭ.

At least 19 recordsLinked to original sources
PubMed1989

[Role of sex dimorphism in the pharmacological action of etimizol].

It has been shown that in female rats the level of ACTH, corticosterone in the blood, relative mass of adrenals, maintenance of T3, T4 in the serum and liver was significantly higher, but the activity of liver enzyme microsomes system was lower than in males; no sex differences were observed in myocardial creatine phosphokinase system. The influence of the etimizol on the female rats significantly speed up amidopyrine N-demethylation and biotransformation of hexobarbital. In males these systems react less on etimizol, but it reduces the speed of amidopyrine N-demethylation.

Adrenal Glands↗
PubMedDate not supplied

[Study of the effects of various physiological endocrine relations at the liver level].

It is shown that predominance of male sex hormones in the rat organism decreases corticosterone in the liver, while that of female sex hormones increases it. The abundance of the thyroxine promotes a rise of blood in testosterone of males and reduces the estradiol in the females, but the blood content of corticosterone significantly decreases in blood and increases in the liver of rats of both sexes. While performing thyroidectomy the level of sex hormones reduces, but the content of glucocorticoid in the liver only slightly changes.

Animals↗
PubMedDate not supplied

[Pharmacodynamics of anti-inflammatory preparations in body exposure to a physical therapeutic factor].

The analgetic and antipyretic action of acetylsalicylic acid is potentiated, whereas that of butadion and amidopyrine is decreased in the conditions of prior action of peloid skin applications (body temperature 42 degrees C). The effect of phenobarbital rises and that of butadion remains unchanged, whereas the inhibitory effect of ethazol revealed in the course of investigations of levelled under conditions of the action of the physical factor on the microsomal system. This leads to the changes in biotransformation and pharmacodynamics of the drugs.

Aminopyrine↗