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Biomedical subjects

A Feldman

Publications and source records attributed to A Feldman.

At least 55 records · Page 3Linked to original sources
PubMed1988

Evaluation of diagnostic criteria for borderline personality disorder.

A comparison of 17 narrowly defined borderline patients with 20 nonpatient control subjects indicated that certain individual and combinations of criteria may be more highly correlated with the disorder than others. Requiring any four or certain specific combinations of two or three of the five most discriminating criteria provided the optimal balance of sensitivity, specificity, predictive power, and diagnostic efficiency considerations. Fewer than five DSM-III-R criteria adequately identified the patients.

Adolescent↗
PubMed1987

Heat-sensitivity of the Harding-Passey melanoma.

We have shown that the Harding-Passey melanoma is heat-sensitive. Its heat-sensitivity increases as the tumor develops in the host. Excision achieved a higher percentage of long-term cure than hyperthermia, during the time period of tumor development studied in these experiments, but did not give the host long-term protection from subsequent tumor challenge.

Animals↗
PubMed1987

Variability in production and immunoreactivity of in-vitro secreted human thyroglobulin.

We examined basal and bTSH-stimulated human thyroglobulin (hTg) secretion by autologous normal and abnormal (benign and malignant) human thyroid cell monolayers. Basal and bTSH-stimulated hTg secretion was highly variable and ranged from 50-700 ng/ml/10(5) cells over a 6 day period. All normal and benign 'non-functioning' adenoma cells demonstrated a dose and time related stimulation of hTg secretion in response to bTSH. Comparison of hTG secretion by autologous normal and abnormal cells showed that in six of eight pairs, the normal thyroid cells had a greater output of hTg than the benign adenoma cells in contrast to our previous studies using non-autologous cells. Malignant thyroid cell hTg production was less predictable than that obtained with normal and benign thyroid cells varying from absent to normal responses to bTSH. Characterization studies of the secreted hTg showed no difference between normal, benign and malignant thyroid cell hTg with reference to molecular weight. However, hTg secreted in vitro was non-iodinated and had a marked reduction (up to 200-fold) in immunoreactivity assessed by both polyclonal and monoclonal antibodies to hTg when compared to hTg standard prepared from intact thyroid tissue (which had 4.58 micrograms iodine/mg). This reduction in hTg immunoreactivity was greatest for hTg secreted by malignant thyroid cells. These data demonstrate the wide variability in the hTg secretory capacity of human thyroid cell monolayers and indicate, when compared to autologous normal cells, that abnormal human thyroid epithelial cells may be relatively deficient in their ability to secrete hTg in vitro. There were also qualitative differences in the immunoreactivity, and iodine content, of in-vitro secreted hTg. These observations suggest that there may be much greater heterogeneity in hTg secreted in vitro than previously realized, perhaps secondary to differences in iodine content and/or degree of glycosylation. Human thyroglobulin (hTg) is the major secretory protein of the thyroid cell (Van Herle et al., 1979). Intracellular hTg is the site of thyroid hormone iodination yet its extrathyroidal role, if any, remains unclear. While hTg is usually present in the peripheral circulation of normal individuals, in species of differing molecular weight (Feldt-Rasmussen et al., 1978), there have been few studies of in-vitro production of hTg by isolated human thyroid cells. Our interest in hTg is in its role as an antigen in thyroid autoimmune disease (De Bernardo et al., 1983; 1986).(ABSTRACT TRUNCATED AT 400 WORDS)

Adenoma↗
PubMed1987

The dying patient.

The dying patient experiences extraordinary emotional stress, as do the family and physician. Their distress is compounded by the fact that members of our society are poorly prepared to deal with death. The defenses that individuals mobilize to deal with their death-anxiety are often maladaptive. The psychiatrist, through the use of understanding of psycho-dynamics, can help herself or himself and then others in responding adaptively to the dying patient. Most medical schools all but ignore death education, despite the clear relevance of such teaching to their students. Psychiatric educators have a role to play in developing and implementing the psychological study of terminal illness in medical schools.

Anger↗