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A Fisseler-Eckhoff

Publications and source records attributed to A Fisseler-Eckhoff.

41 records · Page 3Linked to original sources
PubMed1988

What's new in lung tumor heterogeneity?

The categorization of lung tumors into histologically defined groups and subtypes is based on morphometric criteria, on various degrees of tumoral differentiation and growth patterns. Light microscopic examination of different sections of one and the same tumor reveals in more than 30% of the cases investigated a qualitative and quantitative heterogeneous cell and tumor growth pattern, which is further proved by additional immunohistochemical, electronmicroscopic and DNA-flow cytometry studies. According to observations on the ultrastructural level mixed or combined morphologic features signaling abnormal differentiation patterns in preneoplastic lesions of the bronchial mucosa were visible. So-called amphicrine cells containing mucous vacuoles as well as granules of neurosecretory type were found in basal cell and goblet cell hyperplasia. Squamous-type cells predominate in epidermoid metaplasia and in dysplasia. Cells containing mucous granules or tonofilaments and scant granules of dense core-type suggestive of squamous neurosecretory differentiation were present in all lesions. The ultrastructural features were correlated with the bronchial carcinoma cell heterogeneity and histogenesis.

Adenocarcinoma↗
PubMed1987

Stromal composition in bronchogenic carcinomas--morphometric structure analysis.

So far little is known about the pathogenesis and development of the stroma in bronchogenic neoplasia. Clinical and radiological findings and morphological pictures of the tumor taken just after resection, don't reveal information about the pathogenesis and duration of the development of the scar tissue. Using an automatic image analyser (Quantimet 720, Imanco) it was possible to do morphometrical studies of bronchial carcinomas. We correlated the quantity of the stromal reaction in bronchial carcinomas to the size and histological type of the tumor. 60 peripheral, completely excised bronchial tumors were studied using post mortem and surgically removed specimens (25 adenocarcinomas, 22 squamous cell carcinomas, 13 oat cell carcinomas). The mesenchyme was studied histologically and morphometrically at the point of largest circumference of the tumor. Different histological stains were used to identify and correlate epithelial, mesenchymal and necrotic parts of the tumor. Adenocarcinomas on average have 48% stromal composition and even tumors sized 1.5-3 cm2 show evidence of extensive scar tissue. Squamous cell carcinomas have 37% and oat cell carcinomas have 30% fibrous tissue composition. Large adenocarcinomas have less stroma whereas large squamous cell carcinomas showed a relative increase in stromal composition. None of the above was shown in oat cell carcinomas. The amount of stromal tissue therefore depends on the histological tumor type.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenocarcinoma↗
PubMedDate not supplied

[Ultrasound morphologic criteria in evaluating meniscus changes--an experimental study].

Experimental data and clinical experience with ultrasonography have demonstrated good results in the evaluation of internal derangements of the knee. But the value of ultrasound of the menisci still is controversial. The following investigations compare sonography with histologic results. In a water bath 64 cadaveric menisci were examined with a 5 MHz phased array sector scan. Pathologic conditions like natural or artificial tears, meniscal degeneration and crystal deposition diseases gave different echoes. In cases of vertical meniscal tears, a sharp and bright line-echo is seen on the screen. Due to this consistent reflexion, different types of meniscal tears cannot be differentiated by ultrasound. Severe degrees of meniscal soft tissue degeneration, proven histologically, were shown as hypoechoic areas. Following this experimental results, sonography is a useful modality in the diagnosis of meniscal disorders.

Adult↗
PubMedDate not supplied

Long-term response of primary biliary cirrhosis (stage I) to therapy with ursodeoxycholic acid.

We report about a 56-year-old asymptomatic female patient, who was examined in April 1991 for an increase of biochemical parameters of the liver. Based on the biochemical and serological results (abnormal cholestatic liver function tests, positive antimitochondrial antibodies) as well as liver biopsy primary biliary cirrhosis stage I was diagnosed. Therapy with ursodeoxycholic acid (12mg/kg body-weight/die) was started. Follow-up examinations indicated that cholestatic parameters had normalized and antimitochondrial antibodies became negative. In a further biopsy of the liver nearly regular liver parenchyma was demonstrated. Thus, therapy with ursodeoxycholic acid was stopped. However, in November 1992 cholestatic parameters increased again and, antimitochondrial antibodies recurred (subtype anti-M9: positive) without any clinical symptoms. Ursodeoxycholic acid therapy was reintroduced again. Within 3 months cholestatic parameters returned to normal and antimitochondrial antibodies were eliminated again. Since then ursodeoxycholic acid has been given continuously and a long-term remission as defined by clinical, serological and histological criteria could be maintained until today. This case report indicates a serological remission and a marked histological improvement in a female patient with an early stage of primary biliary cirrhosis (stage I) during therapy under ursodeoxycholic acid. It has to be discussed whether certain early stages of primary biliary cirrhosis with benign antimitochondrial antibody-profile (anti-M9: positive) respond well to long-term treatment with ursodeoxycholic acid.

Bile Ducts, Intrahepatic↗