Experimental endometriosis: a microsurgical animal model in rats.
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Biomedical subjects
Publications and source records attributed to A Golan.
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Retrospectively the records of 155 patients with an acute pelvic abscess who were treated by colpotomy drainage were studied. The more aggressive management, i.e. surgery, is to be preferred and the vaginal approach gives good results. The complications and morbidity in this series were very low and the mortality less than 1%. The procedure itself is simple and requires no special skill or great experience.
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The incidence of and mortality from diffuse peritoneal sepsis associated with the vaginal drainage of pelvic abscesses were retrospectively studied at two hospitals. During the 16-year period from 1961 through 1977 at the University of Mississippi Medical Center, 50 patients underwent colpotomy drainage of pelvic abscesses, diffuse peritoneal sepsis occurred in 5 cases (10%), and 2 of these 5 patients died (40%). During the five-year period from 1972 through 1976 at Baragwanath Hospital, 298 patients underwent colpotomy drainage of pelvic abscess, diffuse peritoneal spesis occurred in 18 cases (6%), and 4 of these 18 patients died (22%). By combining the two series, a total of 348 cases of colpotomy drainage yielded 23 instances of diffuse peritoneal sepsis (6.5%0, with six deaths attributable to this condition (26%). The overall mortality for the 348 cases was 2% (seven deaths), and diffuse peritoneal sepsis was the cause of six of the seven fatalities. It is concluded that colpotomy drainage of pelvic abscesses is a safe and most effective procedure provided that the cases are well selected and the postoperative course is closely followed. Neglect of these basic principles may result in the development of diffuse peritoneal sepsis in a small but important group of patients.
Fifteen patients who had sustained trauma in the last trimester of pregnancy were studied at the Baragwanath Hospital, Johannesburg. The presentation, management and outcome of the pregnancies are briefly discussed, and the relevant literature is reviewed.
Ninety-three incidents of uterine rupture are reviewed. There is a distinct difference in both the fetal and maternal outcome between the group with a previously scarred uterus and the group with no previous scarring. Rupture of the unscarred uterus is a more dramatic event. The most common etiologic factors appear to be oxytocin, cephalopelvic disproportion, grand multiparity, and abruptio placentae. Abruptio placentae was diagnosed in almost half the maternal deaths. When the uterine tear is longitudinal, the maternal and fetal prognosis is relatively poor. Fetal mortality is much higher in patients with an unscarred uterus. Hysterectomy was more commonly performed in this group. Rupture of a previously scarred uterus is usually incomplete and the tear is transverse. Maternal and fetal prognosis is much better and repair of the uterus with sterilization is more often feasible in this situation.
Two cases of dystocia due to retroperitoneal tumours of the nervous system are described, as well as the patients' course, obstetric management and a review of the literature.
The association of an ovarian dysgerminoma with embryonal carcinoma in a 19-year-old woman is described. This is a highly malignant combination resulting in very rapid tumour growth and dissemination. A case report is presented and the aetiology, malignant potential and subsequent management of this most unusual tumour are discussed.
A resume of the aetiology, precipitating factors, pathology and management of spontaneous rupture of the liver in pregnancy, with a report of 5 cases, is presented. Misdiagnosis and late treatment contribute to the high mortality rate. Pre-operative diagnosis is very rare despite the fact that this is a diagnosable syndrome in pregnant multiparas with evidence of pre-eclampsia or eclampsia, and right-sided hypochondrial or epigastric pain which rapidly progresses to peripheral vascular collapse, often with signs of intraperitoneal haemorrhage. An awareness of this syndrome and early active surgical management constitute the best and only chance of survival for these patients.
Thirty-four patients with carcinoma of the ovary were compared with controls matched for age, sex and racial origin. Previous mumps infection was determined by taking a history from the patient, by complement fixation test and by estimating neutralizing antibody titre. No significant differences between the two groups were found for any of the three methods used to estimate previous exposure to mumps virus. Therefore this study did not confirm previous hypotheses that mumps infection confers a significant degree of protection against the development of ovarian cancer. A relatively small proportion of cases could possibly be due to lack of such protection, but in this study not more than 30% at the 5% fiducial limit.
A series of 61 triplet pregnancies delivered in the Baragwanath Hospital for the 10 years 1967 - 1976 is analysed, the incidence being 1 : 2 789 deliveries. The average maternal age was 29,6 years, and average parity 3,7; 60% had had adequate antenatal care, a figure significantly higher than that for the local normal pregnant population. The vast majority of the patients had vaginal deliveries, although the proportion of manipulative procedures was high. The duration of labour was strikingly short in most instances. The fetal outcome was impressively good, although somewhat better with the second triplet than with the other two. This indicates that, in spite of the recent tendency towards liberal use of caesarean sections in these patients, a careful and appropriate vaginal approach has its merits.
Eighty-four ovarian cancer (OCa) patients and 84 controls with nonmalignant conditions matched by age and ethnic origin were interviewed with regard to clinical mumps history and their sera were tested for complement fixation (CF) mumps antibodies. OCa patients differed from the controls in the response to past mumps infection in two respects: 1) They appeared to be more likely to have developed subclinical mumps as evidenced by a lower rate of clinical mumps history in the presence of serological evidence of similar infection rates among those with positive and those with negative clinical mumps history. 2) They tended to present lower persistent mumps CF antibody titers. These results may be interpreted to indicate that an immunological incompetence enables the development of OCa possibly through a direct etiologic role of mumps virus.
Two patients with unequivocal primary ovarian pregnancies are presented, one with an intra-uterine contraceptive device in situ. The increased prevalence of primary ovarian pregnancies, as revealed in the English literature, and the increasing association of extra-uterine pregnancies with intra-uterine contraceptive devices in situ, are discussed.
A case of haemoperitoneum due to placenta percreta occurring at approximately 22 weeks' gestation is presented. The diagnosis and treatment are discussed.
A case of intermittent exophthalmos due to orbital venous veins in which there were associated varicose veins of the legs is described. Of note was the preservation of vision despite the long history (28 years) of the disturbance.
A patient with hyperparathyroidism and corneal calcifications is reported. The calcifications appeared following phosphate treatment and persisted for 31/2 years, despite local instillation of EDTA. Local application of EDTA after mechanical removal of the corneal epithelium completely eliminated the corneal deposits.