Homoanalogues of aldofuranosyl-nucleosides. 8. 1-(3,6-anhydro-1-deoxy-D(and L)-galactitol-1-yl)pyrimidines ("bis-homonucleosides").
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Biomedical subjects
Publications and source records attributed to A Guarnieri.
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The treatment of mixed cryoglobulinemia concurrent with HCV infection is still under debate. We report the case of a patient referred to our unit for a membranoproliferative glomerulonephritis associated with HCV infection. A nephrotic syndrome and a slight reduction of glomerular filtration rate were present. We treated him with alpha-interferon for six months and prednisone for two months. We achieved a remission of the nephrotic syndrome without any significant reduction of the viral load. One year after the therapy had been suspended, the nephrotic syndrome relapsed and subsequently responded to a combined treatment with interferon ribavirin and prednisone. HCV-RNA became suddenly and persistently negative.