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Biomedical subjects

A Guseo

Publications and source records attributed to A Guseo.

26 records · Page 2Linked to original sources
PubMed1975

An adult case of metachromatic leukodystrophy. Light, polarization and electron microscopic study.

The findings are described in an adult case of metachromatic leukodystrophy examined by light, polarization and electron microscopy. Symmetrical demyelination was found in the cerebral hemispheres, but was moderate in the cerebellum, brain stem and spinal cord. Early changes in myelin of peripheral nerves have been demonstrated by polarization microscopy. Various metachromatic structures have been described in glial cells and neurons by electron microscopy, indicating disturbances at different metabolic steps of lipid metabolism. There are minor but no essential ultrastructural differences in the disease of different ages.

Adult↗
PubMed1975

Electron microscopy of lymphocytic leukaemia cells in the cerebrospinal fluid.

The ultrastructure of cells in the CSF are reported in 2 cases of lymphocytic leukaemia of the CNS. Unusual nuclear pockets, margination of the nuclear chromatin and fragmentation of the nuclei were frequent in the first case, whereas in the second nuclear pockets were rare and deep indentations of the nuclei frequent.

Cell Nucleus↗
PubMed1975

Ultrastructure of calcification in Sturge-Weber Disease.

The ultrastructure of calcareous deposits in a case of Sturge-Weber disease is described. Concrements were found mainly extracellularly, outside of blood vessels, but there were some also within the vessel walls. The laminated concrements are built up of fine filaments, similar to those seen in the Fahr's disease. Needle-like cristals (calcium apatit) were observed within the concrements. Increased permeability of the altered vessel walls may be responsible for these alterations.

Angiomatosis↗
PubMed1975

[Electron microscopic study of striatodental calcification (Fahr) (author's transl].

In a woman, aged 52, who had impaired phosphate excretion and low serum calcium levels, abundant calcium deposits (Pseudokalk) were found between the basement membranes of blood vessels in the regions of corpus striatum and nucleus dentatus as well as in the subcortical white matter and centrum semiovale. Calcium deposits were found also outside blood vessels but always in the vicinity of the basement membrane. These can be phagocytozed by makrophages or astrocytes. Calcium deposits have a characteristic ultrastructure. They are built up of 140-400 A electron lucent filaments (acid mucopolysaccharid?) within which electron dark segments built up of 40-80 A units (calcium deposits?) are found. The concentric rings of calcified deposits are of reflection of differing density of aggregation of dark filaments. The growth of the deposits takes place by additional precipitation. In the development of calcification of the cerebral blood vessels in Fahr's disease, the role of high serum phosphate levels, the increased permeability and dysfunction of mesenchymal cells of the vessel walls are discussed.

Autopsy↗