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Biomedical subjects

A H Nagi

Publications and source records attributed to A H Nagi.

At least 19 recordsLinked to original sources
PubMed1996

A randomized double-blind comparative study of terbinafine for 1, 2 and 4 weeks in tinea capitis.

We report a randomized, double-blind study, comparing the relative efficacy and tolerability of oral terbinafine, given for 1, 2 or 4 weeks, in tinea capitis. Of 161 evaluable patients, 53 were treated with terbinafine for 1 week, 51 for 2 weeks and 57 for 4 weeks. Isolated pathogens included Trichophyton violaceum (71.5%), T. tonsurans (14.9%), T. verrucosum (4.3%), Microsporum audouinii (4.3%), M. canis (2.5%), T. schoenleinii (1.9%) and T. mentagrophytes (0.6%). The final evaluation, at 12 weeks, showed cure rates of 73.6, 80.4 and 85.9%, in the respective groups. The adverse effects noted, were not drug related. In our opinion, terbinafine given for 1, 2 or 4 weeks, is equally effective for most cases of tinea capitis.

Adolescent↗
PubMed1994

Tinea capitis in Lahore, Pakistan.

BACKGROUND: The causative fungi of tinea capitis vary with geography and time. This study was planned to identify the etiologic agents and determine clinicoetiologic correlations of tinea capitis in Lahore, Pakistan. METHODS: From clinically suspected cases of tinea capitis, skin scrapings and hair samples were taken and subjected to microscopy and culture. RESULTS: Of 180 evaluable patients, 95% were children below 12 years of age with equal sex incidence. Noninflammatory lesions were seen in 62.2% of cases. Trichophyton violaceum was the most common etiologic agent responsible for 69.4% of infection, followed by T. tonsurans (16.7%), T. verrucosum (10%), Microsporum audouinii (2.2%), and T. mentagrophytes (1.7%). CONCLUSIONS: T. violaceum is the predominant pathogen causing tinea capitis in children and adults in this part of the world and gives rise to a varied clinical picture. Our findings agree with data from other parts of Pakistan and many countries abroad.

Adolescent↗
PubMed1992

An open clinical pilot study of the efficacy and safety of oral terbinafine in dry non-inflammatory tinea capitis.

Ten patients with dry non-inflammatory tinea capitis were evaluated in a pilot study which ran from September 1989 to February 1990. Each patient was given oral terbinafine for 6 weeks; each was followed up 2 weeks later. Eight (80%) were completely cured, one (10%) was mycologically cured and showed minimal signs and symptoms, and another (10%) showed improvement (negative mycology, but persistent clinical signs and symptoms). No topical or systemic side-effects were noted. Terbinafine appears to be an effective and safe antifungal agent in the treatment of non-inflammatory tinea capitis.

Adolescent↗
PubMed1992

An immunofluorescence study of renal lesions in diabetes mellitus.

Percutaneous renal biopsies were performed in 30 diabetic patients who presented with proteinuria. Tissues were studied for evidence of an immune lesion using immunofluorescence techniques. No consistent pattern of binding of FITC labelled polyvalent, monospecific IgG, IgA, IgM and labelled bovine insulin antisera in various diabetic renal lesions could be demonstrated. The binding of labelled insulin was observed even in biopsies of patients who had never received exogenous insulin therapy. It was therefore concluded that there is no evidence to support an immune pathogenesis in the morphogenesis of the diabetic renal lesions, nor do these lesions occur as a result of insulin therapy.

Adult↗
PubMed1984

Gold nephropathy in rabbits using an indigenous preparation. A morphological study.

Experimental nephropathy has been induced in rabbits using an indigenous preparation of gold, popularly known as "Gold Kushta ". Proteinuria and associated renal glomerular lesions of variable severity were observed in the animals on Kushta feed and those injected with sodium aurothiomalate. In addition, a probable mechanism of gold-induced nephropathy is also discussed.

Animal Feed↗
PubMed1984

Effects of prolonged poisoning by Russell's viper venom on blood coagulation, platelets and fibrinolysis.

The effects of Russell's viper venom on blood coagulation, platelets and the fibrinolytic enzyme system were studied in rabbits after injecting repeated doses of 0.05 MLD of the venom. Thrombocytopenia was the earliest change to appear. It was followed by rise in serum fibrinogen degradation products and prolongation of prothrombin time, activated partial thromboplastin time and thrombin time indicating a progressive consumption coagulopathy and activation of fibrinolysis. Red blood cell morphology was unchanged during the first three weeks; whereas the fragmentation appeared after the fourth week and it increased in severity with further envenomations, i.e. when chronic DIC was established.

Animals↗