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Biomedical subjects

A Haycox

Publications and source records attributed to A Haycox.

45 records · Page 3Linked to original sources

Drug rationing in the UK National Health Service. Current status and future prospects.

There are major problems in attempting to ration drug use in the UK. These include the large indigenous pharmaceutical industry, the nature of funding of drugs within the National Health Service (NHS) and the political sensitivities of rationing. Rationing of services within the NHS has therefore usually been implicit rather than explicit, and there is little public debate about rationing of health services. In relation to drug therapy, prescribing in primary care technically can only be rationed by encouraging the general practitioner (GP) to contain his or her own costs-effectively moving the difficult decision to the GP. Direct incentives to the GP, in the form of incentive payments or by fundholding seem to have some success in containing costs, largely by simple generic substitution. There are established systems in hospitals to control the costs of drugs, including formularies and drug management committees. Hospitals commonly try to transfer drug costs to the GP budget. While in part this is clinically appropriate, it can lead to tensions. Health authorities and GP fundholders now include prescribing, particularly at this interface, in their contracts with hospitals. Economic evaluations currently play little part in aiding decisions about choice of drug. These decisions tend to be dominated by the need for short term cost containment in the UK. Recent reforms of the NHS have moved responsibility for the rationing of services to the local authorities or purchasers; this might in time create an additional, local hurdle for pharmaceutical companies trying to market new drugs. A proposal to introduce a national limited formulary in which drugs will be selected partly on the basis of an economic evaluation seems impractical, although similar ideas might be further developed.

Health Care Rationing↗

The cost effectiveness of renal provision in the UK.

Discusses the need for reliable research-based evidence detailing the costs and benefits provided by different operational and strategic structures of renal replacement therapy. Suggests that in choosing the most appropriate form of dialysis the treatment options may be limited for clinical, practical or financial reasons. Proposes that the renal services must support patients in empowering them to make informed choices concerning the dialysis modality which offers them the highest quality of life. Brings into perspective the need for a balance between patients' quality of life and the financial constraints on the NHS.

Adaptation, Psychological↗

Information requirements underlying medical decision making in the diagnosis and early management of spontaneous subarachnoid hemorrhage.

The research reported here investigated an area in which improved information would significantly enhance decision making focusing upon the diagnosis and management of spontaneous subarachnoid hemorrhage (SAH). The incidence of SAH is low, but morbidity and mortality are high. Furthermore, nonspecialists acting as gatekeepers to specialist care may not possess the required knowledge base and diagnostic skills to make reasonable decisions. The information used by experts was evaluated and an expert consensus established. An analysis of nonspecialist decision making was then completed, and finally the expert consensus was utilized to identify both the information deficits and the training requirements of nonspecialists.

Decision Theory↗

Economic analysis in the evaluation of health promotion.

The problems of using cost-effectiveness analysis in health promotion are set out in order to argue against the simplistic application of QALY-type analysis between the preventive and curative sectors. The difficulties of conceptualizing and measuring 'effectiveness', and the obstacle of achieving predictive validity in cost-effectiveness analysis are discussed.

Cost-Benefit Analysis↗

Cost structures in a large hospital for the mentally handicapped.

Health authorities in the U.K. have, in recent years, become increasingly aware of the financial costs of health care provision, and have sought ways in which such costs can be reduced without detriment to the service provided. This study estimates cost functions for the case of a large hospital treating the mentally handicapped. Factors which influence the variation of costs between wards in the same hospital include, inter alia, the age of the residents, the severity of their handicap and the number of residents living on the ward. Costs vary non-linearly with the latter of those variables, and so the possible existence of an optimal ward size emerges. The paper concludes with the estimation of this optimum, together with an examination of factors which might cause the optimal ward size to vary.

Age Factors↗

Side effects of influenza vaccination in healthy older people: a randomised single-blind placebo-controlled trial.

OBJECTIVES: To investigate the frequency of side effects following influenza vaccination in healthy participants aged 65-74 years. MATERIALS AND METHODS: A single-blind randomised placebo-controlled trial was performed in general practices in central Liverpool on 729 healthy individuals (341 females and 388 males) aged 65-74 (median age 68.9) years, of whom 552 received influenza vaccine and 177 received placebo. The main outcome measures were analysed from adverse reactions reported by the subjects on a postal questionnaire 3 days after vaccination. RESULTS: 724 (99.3%) questionnaires were returned. 62 (11.3%) participants who received influenza vaccination complained of local symptoms compared with 9 (5.1%) participants who received placebo (difference 6.2%; 95% CI 1.3 to 10.0%; p = 0.02). 192 (35.1%) individuals who received influenza vaccine complained of one or more systemic side effects compared with 75 (42.4%) who received placebo (difference -7.3%; 95% CI -15.6 to 0.9%; p = 0.10). CONCLUSION: Healthy people belonging to this age group can be reassured that, when compared with placebo, influenza vaccination causes few, if any, systemic side effects and only a low incidence of local side effects.

Age Factors↗