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Biomedical subjects

A I Hurvitz

Publications and source records attributed to A I Hurvitz.

At least 55 records · Page 3Linked to original sources
PubMed1980

Canine hepatic neoplasms: a clinicopathologic study.

One hundred ten primary hepatic neoplasms, excluding hematopoietic and vascular tumors, were diagnosed in 12,245 canine necropsies. Included were 55 hepatocellular carcinomas, 24 bile duct carcinomas, 2 combined hepatocellular and cholangiocarcinomas, 15 carcinoids and 14 sarcomas. A majority of the dogs with hepatocellular carcinoma (80%), bile duct carcinoma (65%) and sarcoma (61%) were 10 years old or older; 71% of the dogs with carcinoid were under 10 years old. Hepatocellular carcinoma and sarcoma occurred more often in males, bile duct carcinoma in females, and no sex predisposition was found in dogs with carcinoid. All dogs had hematologic and biochemical abnormalities relating to liver function. The aspartate amino transferase/alanine amino transferase ratio was less than one in cases of hepatocellular carcinoma and bile duct carcinoma, and more than one in cases of carcinoid and sarcoma. A massive lesion in one of the liver lobes was the most common gross morphologic feature in cases of hepatocellular carcinomoa and bile duct carcinoma, with the left lateral lobe affected most often. In cases of carcinoid, most of the lesions were diffuse. The most common sites of metastases were lymph nodes and lungs for hepatocellular carcinoma and bile duct carcinoma, lymph nodes and peritoneum for carcinoid, and spleen for sarcoma.

Age Factors↗
PubMed1980

Circulating immune complexes in sera of dogs with benign and malignant breast disease.

The Raji cell radioimmunoassay was adapted to measure circulating immune complexes (CIC's) in the sera of 74 dogs with benign and malignant breast disease. In dogs with recently diagnosed spontaneous breast cancer, 57% (29 of 51) had elevated CIC's, with some levels as high as those found in the sera of dogs with systemic lupus erythematosus. The sera of 10 of 23 dogs with benign breast disease also demonstrated elevated levels of CIC's. Two weeks following mastectomy, repeat CIC levels were obtained in 30 dogs. Elevated CIC levels returned to normal in all dogs with benign breast disease but in only 33% of dogs with breast cancer. Dogs with persistent elevation of CIC's were at greater risk of developing metastatic breast cancer. Serum total hemolytic complement was significantly higher (p < 0.05) in dogs with untreated breast cancer than in healthy dogs but did not correlate with the level of CIC's found. Two weeks after mastectomy, total hemolytic complement levels had returned to normal. By sucrose density gradient ultracentrifugation, the complexes were shown to sediment at 19 S. These studies indicate that the dog may be a good model for elucidating the significance of elevated CIC's in breast cancer.

Adenocarcinoma↗
PubMed1977

Hyperviscosity syndrome associated with lymphocytic leukemia in three dogs.

Hyperviscosity syndrome was associated with increased plasma content of monoclonal immunoglobulin (IgA or IgM) in 3 dogs with lymphocytic leukemia. The diagnosis of lymphocytic leukemia was based on the finding of a large number of mature lymphocytes in the blood and bone marrow. The clinical signs included weakness, lethargy, depression, and coughing due to congestive heart failure. Consistent physical findings were splenomegaly, with or without peripheral lymphadenopathy, and funduscopic abnormalities. Of the 2 dogs treated successfully with chlorambucil, 1 remains in remission after withdrawal of the drug for over 1 year.

Animals↗
PubMed1977

Idiopathic monoclonal (IgA) gammopathy in a dog.

Idiopathic monoclonal (IgA) gammopathy in a dog was differentiated from multiple myeloma, based on the lack of Bence Jones proteinuria, no osteolysis, and no plasma cell infiltration into bone marrow, as well as on the stability of the gammopathy for over 18 months. The dog was not treated but remained clinically normal for 18 months.

Animals↗
PubMed1977

Monoclonal cryoglobulinemia with macroglobulinemia in a dog.

A 9-year old female Doberman Pinscher had a 5-month history of epistaxis. On routine testing of the dog's serum, blockage of the intake tubes of the equipment resulted. At this point, cryoglobulinemia was suspected and was later confirmed to be due to a monoclonal cryoglobulin (IgM), by means of immunochemical studies. Clinical recovery was achieved by use of cytotoxic drugs.

Animals↗
PubMed1975

A disease in dogs resembling human pemphigus vulgaris: case reports.

A pemphigus-like disease occurred in 5 dogs. The canine disease closely resembled pemphigus vulgaris in man and was characterized by ulcerative lesions in the oral cavity, on the skin, and at mucocutaneous junctions. Histologically, the first sign of the disease was disappearance of the intercellular bridges in the lower epidermis. The resulting acantholysis was diagnostic for pemphigus. Antibodies to the intercellular space substance were detected by immunofluorescent staining in serum of 4 of the dogs. High doses of corticosteroids were effective in controlling the disease.

Acantholysis↗
PubMed1975

Primary tumors of the spinal cord and meninges in six dogs.

Primary spinal cord tumors were detected in 6 mature dogs. Two of the tumors were astrocytomas, 2 were meningiomas, and 2 were neurilemmomas. Five tumors were in the cervical portion and 1 was in the lumbar portion of the spinal cord.

Animals↗
PubMed1975

Nonhematopoietic neoplasms in cats.

In a study of 3,145 feline necropsies conducted for 11 years by the pathology department of The Animal Medical Center, 289 tumors of nonhematopoietic origin were found in 264 cats. Malignant and epithelial tumors were more common than benign or mesenchymal tumors in all ages and breeds, and in both sexes. They were also more common in female cats than in males, even after mammary neoplasms were excluded. Analysis of groups of tumors according to their tissue of origin indicated some sex and breed dispositions not observed before. Pulmonary carcinomas and osteosarcomas were more frequent in domestic short haired cats than in other breeds, whereas intestinal carcinomas occurred more often in Siamese cats. Female predominated in pulmonary carcinomas, hemangiosarcomas, osteosarcomas, and squamous cell carcinomas, but males outnumbered the females in intestinal carcinomas.

Age Factors↗
PubMed1972

A DNA-binding protein in the serum of certain mammalian species.

Various mammalian species contain an anionic serum protein that reacts specifically with native DNA. It is considerably less reactive with single-strand DNA and does not react with monodeoxyribonucleotides, homopolyribonucleotides, or duplexes of homopolyribonucleotides. Synthetic dA.dT was an effective inhibitor of the reaction with native DNA, while Micrococcus luteus DNA and dG.dC were not inhibitory. This protein was encountered in the course of studies on DNA antibodies. Although it reacted with red cells coated with DNA and gave agar precipitation bands, it was clearly distinct from DNA antibodies. It was found in the serum of all animals of a given species, migrated as an alpha-beta globulin, and did not crossreact with gammaglobulins. It reacted with DNA in solution to give precipitation curves that were strongly influenced by changes in ionic strength. The protein was isolated from canine serum by precipitation with DNA and purified to homogeneity, as judged by immunochemical and electrophoretic criteria.A similar protein was found in mink, equine, and other sera, but not in human sera. Previous studies on DNA antibodies in certain experimental animals may have given false positive results due to this protein.

Animals↗